Quantum confined CsPbBr3 nanocrystals (NCs) with adjustable photoluminescence (PL) in the range of 470–500 nm are particularly desirable for applications in light-emitting diodes and many quantum technologies. Exploration of the full potential of these perovskite NCs requires an understanding of the random fluctuation of their PL at the single-particle level, commonly termed as blinking. In this work, we study the PL blinking of quantum confined single NCs of CsPbBr3 of three different sizes between 3.80 and 5.90 nm in immobilized and fluid conditions to understand the recombination pathways and dynamics of the photogenerated charge carriers. In the immobilized state, the PL intensity trajectories and PL lifetime-intensity distributions of these single NCs reveal the contributions of both Auger recombination and trapping of hot carriers to the PL fluctuation. The results suggest a higher carrier trapping rate constant for smaller NCs. The fluorescence correlation spectroscopy and fluorescence lifetime correlation spectroscopy measurements on freely diffusing NCs show a higher off-state fraction and lower per-particle brightness of the smaller NCs. It is concluded that a larger trap depth and higher probability density of the carriers at the surface in smaller NCs make the trapping process more feasible and detrapping more difficult. The results provide first information on the effect of size on PL blinking of the quantum confined CsPbBr3 NCs, and this knowledge is expected to be useful in better designing photoluminescent samples of this class for optoelectronic applications.
Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma that affects mature B cells. MCL has been found to have extranodal involvement in the bone marrow, spleen, liver, and gastrointestinal tract. It is most commonly associated with lymphadenopathy and hepatosplenomegaly, but a leukemic presentation is unusual. Colon cancer and mantle cell lymphoma coexisting in the same gut is unusual. This study has been submitted as a case report for publication. After being diagnosed with recurrent mantle cell lymphoma, a 45-year-old male patient was admitted for the third cycle of treatment. A colonoscopy revealed mantle cell lymphoma, which had previously been treated with chemotherapy and now appears to be active in the ileocecal region. A biopsy was performed for further investigation. Histopathology reveals small intestine mantle cell lymphoma, and the patient is currently undergoing chemotherapy. After the third cycle of chemotherapy was planned with medical management, the patient was referred for oncologic treatment. We present a case of MCL with large nodules in the last 5 cm of the ileum, as well as the workup of this uncommon lymphoma, which clinicians may be asked to detect and manage. This report serves as a reminder to maintain a broad differential to account for uncommon diseases and pathology. Practising with a thorough understanding of medical principles and clinical acumen is critical for optimal patient care and, as demonstrated in this case, avoiding a potential surgical intervention that would delay appropriate chemotherapy.
Tecomastans (L.) (Family:Bignoniaceae) is called as yellow elder in english.Traditionally flowers and bark are used for treatment of various cancers. In current study Crude ethanolic leaf extract of Tecomastans(L.)leaves were examined for their anticancer activity. To determine invitro anticancer activity, different concentrations of crude extract were tested on MCF- 7 cancer cell line by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Tecomastansleaf extract showed a significant antiproliferative activity and a dose dependent effect was observed. Minimum inhibition of 14.6 % was shown by extract at concentration 7.8 µg/ml and maximum inhibition (95.9%) was observed at 1000 µg/ml. The plant extract showed activity in potential range for further investigation on cancer cells.
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