Seyed Reza Fatemi

Shahid Beheshti University of Medical Sciences

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Mohammad Reza Zali

Shahid Beheshti University of Medical Sciences

Ebrahim Hajizadeh

Tarbiat Modares University

Seyed Reza Mohebbi

Shahid Beheshti University of Medical Sciences

Mohsen Vahedi

University of Social Welfare and Rehabilitation Sciences

Mahsa Molaei

Shahid Beheshti University

Mohamad Amin Pourhoseingholi

Shahid Beheshti University of Medical Sciences

Pedram Azimzadeh

Kiyatec (United States)

Mohammad Asghari Jafarabadi

Tabriz University of Medical Sciences

Mahdi Montazer Haghighi

Islamic Azad University South Tehran Branch

Anoshirvan Kazemnejad

Tarbiat Modares University

Cooperative Institutions

Shahid Beheshti University of Medical Sciences

101

Shahid Beheshti University

Tehran University of Medical Sciences

University of Tehran

Taleghani General Hospital

Yokohama City University

Shahid Chamran University of Ahvaz

Yokohama City University Hospital

Iran University of Medical Sciences

Tarbiat Modares University

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Hemangioendothelioma as a rare cause of lower gastrointestinal bleeding - a case report

International Journal of Surgery Case Reports (2024)

Seyed Reza Fatemi Alireza Zahedi Mina Moghtaderi Mohammad Reza Hashempour Zhaleh Mohsenifar

Hemangioendothelioma

Gastrointestinal bleeding

10.1016/j.ijscr.2024.110381

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Effect of ZnO nanoparticles on morphine dependence in mice in the presence and absence of vitamin C

Journal of Arak University of Medical Sciences (2015)

Maryam Keiry Mahnaz Kesmati Hossein Najaf Zadeh Seyed Reza Fatemi

Background: With the increasing use of nanoparticles of zinc Oxide (nZnO) in the industry, the pharmaceutical and chemical industry, the effects of the nanoparticles on opioid dependence and its possible interaction with vitamin C (as an antioxidant agent) has not been indicated. This study aimed to clarify the effect of ZnO nanoparticles on morphine dependence in the presence and absence of vitamin C in CPP method. Materials and Methods: In this study, adult male mice weighing 25±3 g were used in the groups which received different doses of morphine(2/5, 5, 10 mg/kg, Sc), Nano ZnO (1, 2.5, 5, 10 mg / kg, IP), vitamin C (1, 5, 25 mg / kg, IP) and groups which receiving combination of vitamin C and nano ZnO. All categories received morphine 5 mg / kg, for induction and diagnosis of dependence in CPP. Results: Nano ZnO concentrations (2.5, 5, 10mg/kg, IP) caused a significant decrease in morphine CPP (p <0.01, p <0.001) and the 1 mg / kg of nano was ineffective. Vitamin C in doses of 5 and 25 mg/kg decreased the expression of morphine-induced conditioned place preference (p <0.01) and a value of 1 mg/kg had no effects. All doses of ZnO in the presence of ineffective dose of vitamin C showed a stronger inhibitory effect than to alone nZnO in morphine CCP. Conclusion: The combination of vitamin C and Nano ZnO are more effective to deal with the psychological dependence to morphin and probably can provide a new approach to addiction treatment.

Conditioned place preference

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Large Gastritis Cystica Polyposa Treated with EMR Polypectomy in Patient without History of Gastric Surgery

Acta Scientific Gastrointestinal Disorders (2021)

Seyed Reza Fatemi Behzad Hatami Naghmeh Salarieh Azam Farahani Seyed Ali Fatemi

Gastritis cystica polyposa (GCP) is a rare inflammatory disease of the gastric remnant that usually develops after partial gastrectomy.It is defined by the presence of polyps on anastomotic gastric junction mucosa, at histopathological examination, by the presence of mucosal and submucosal cysts with foveolar hyperplasia.The disease is characterized by the frequency of gastro-intestinal bleeding and possibility of carcinomatous association.The endoscopic examination of a 51-year-old female without history of gastric surgery revealed a protruding lesion in the greater curvature of the middle third area of stomach.The lesion was 25 mm in size.Polypectomy was performed with snare base method and submucosal stalk injection, with endoscopic impression of hyperplastic polyp, without any complications.Histopathological findings were consistent within gastritis cystic polyposa (GCP).

Polypectomy

Gastric Polyp

10.31080/asgis.2021.04.0273

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The Study of Association between TGF-B1 Gene 915 G>C Polymorphisms and Chronic Hepatitis C Infection

DOAJ (DOAJ: Directory of Open Access Journals) (2011)

Pedram Azimzadeh Seyed Reza Mohebi S Roumani Maryam Vahedi Seyed Reza Fatemi

Hepatitis C

Association (psychology)

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Association of leptin receptor gene Gln223Arg polymorphism with susceptibility to colorectal cancer.

PubMed (2011)

Khatoon Karimi Maral Arkani Akbar Safaei Mohamad Amin Pourhoseingholi Seyed Reza Mohebbi

Leptin is a 16 kDa polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (CRC). Leptin exerts its effect through the leptin receptor (LEPR) a member of the class I cytokine receptor family.We have investigated whether glutamine to arginine substitution (Gln223Arg) in exon 6 of the leptin receptor gene, has implications for susceptibility to CRC.Polymerase chain reaction (PCR) and restriction enzyme digestion (RFLP) was performed to evaluate the association between the Gln223Arg polymorphism of the LEPR and CRC risk in a case-control study in 346 subjects involving 173 cases with CRC and 173 controls.There was no statistically evidence of significant difference in genotype and allele frequencies between the cases with CRC and controls for the Gln223Arg polymorphism of LEPR, before or after adjusting for confounders (age, BMI, sex, and smoking status). Furthermore, no significant difference was observed between the CRC cases and controls by BMI, sex and smoking status.Our findings suggest that the LEPR Gln223Arg polymorphism is not associated with the risk of CRC in Iranian population.

Leptin receptor

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یک تحقیق میدانی در مورد پنج واکسن سرخک تولید شده در سلول دیپلوئید انسانی MRC-5

DOAJ (DOAJ: Directory of Open Access Journals) (1977)

H. Mirchamsy A. Shafyi S. Bahrami Mohammad Kamali P. Nazari

Abstract Five batches of experimental measles vaccines were prepared with Biken-CAM, Schwarz, Sugiyama, Leningrade-16 and AIK-C strains in MRC-5 HDC. The rct40, T50 or neurovirulence for baby hamsters of these viruses adapted to HDC were not significantly changed but the neurovirulence of the Sugiyama virus for day-old hamsters was increased after passages in HDC. With the exception of the AIK-C strain the size of the plaques was increased by 20 passages of virus in MRC-5 cells. The experimental vaccines were evaluated clinically and serologically in a field trial in seronegative children in the Caspian Sea area north of Iran. It was found that: (a) the lowest clinical reactions were recorded for the AIK-C vaccine; (b) the seroconversion was high for all vaccines ranging between 95·5 and 100%; and (c) that the hemagglutination-inhibiting (HI) antibody titers of sera of the vaccinees ranged from 25·2 to 26·5.

10.22092/ari.1977.108801

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The role of kras mutations and MSI status in diagnosis of colorectal cancer.

PubMed (2011)

Atena Irani Shemirani Mahdi Montazer Haghighi Saman Milanizadeh Mohammad Yaghoob Taleghani Seyed Reza Fatemi

The aim of the current investigation was to examine the profile of Kras mutations accompanied with MSI (microsattelite instability) status in polyps and colorectal carcinoma tissues in an Iranian population.Kras mutations in colorectal cancer cause resistance to anti-Epidermal Growth Factor Receptor (EGFR). So it can be considered as a true indicator of EGFR pathway activation status. Kras mutations can be detected in approximately 30% to 40% of all patients with colorectal cancer. The most hot spot of the gene is located in exons 2 and 3.In this study we examined exons 2 and 3 Kras gene using polymerase chain reactions and subsequent sequencing of the exons in 95 patients with sporadic colorectal cancer including 48 tumors and 47 polyps. This study was performed using biopsy samples from the patients. We sequenced the Kras gene in a panel of human colorectal tumors and polyps in addition to detecting MSI status using fluorescent technique.We could detect 6 mutations in tumors including 5 mutations in codon 12 and one mutation in codon 13. Moreover, in polyps 2 mutations were determined in codon 13 and one in codon 12. Microsatellite instability assay revealed the presence of 5 and 6 MSI in tumors and polyps, respectively. Among the MSI mononucleotide markers, NR-21 marker demonstrated the most frequency (60%) in the both groups.Our findings showed that probably the profile of mutations in tumors is not entirely compatible with the pattern of mutations in polyps. However, just one of the mutations, Gly12Asp, was similar in both groups.

Microsatellite Instability

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Evaluation of antibody frequency against HBV, HCV and HTLV-1.

PubMed (2012)

Seyed Mohammad Ebrahim Tahaei Seyed Reza Mohebbi Seyed Reza Fatemi Pedram Azimzadeh Dariush Mirsattari

This study was designed to evaluate the frequency of antibody against these viruses in individuals attending the endoscopy ward of Taleghani hospital Tehran, Iran.Blood-borne viruses such as hepatitis B and hepatitis C virus and HTLV-1 virus are among the world's public health problems. Hepatitis viruses cause liver problems and HTLV-1 infection can lead to adult T-Cell lymphoma (ATL).Blood samples of 219 individuals attending the endoscopy ward of Taleghani hospital between years 2009-2011 were collected. A questionnaire containing demographic data was completed for each subject. Blood samples were tested for antibody against HTLV-1, HCV and HBc by ELISA (Dia.pro Italy). In case of positive results for anti-HBc, samples were also tested for HBs Ag antigen.Ninety two subjects were male and 127 were female. Mean age of the population was 39.87 ± 16.47. None of the subjects had anti-HCV antibody, while 4 of them had anti-HTLV-1 antibody and 26 anti-HBc antibody; which only two of these individuals had HBs Antibody.The results of this study show that frequency of anti-HCV and anti-HTLV-1 antibodies are very low, while the frequency of anti-HBc was higher in the population. Since HTLV-1 is the causative agent of a type of blood cancer, it seems that screening of donated bloods in this region should be considered.

Hepatitis B

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Comparison the Role of BMI, Pathologic Stage and Hereditary Related Factors on Survival between Colon and Rectal Cancers: Frailty Competing Risks Model

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Mohammad Asghari Jafarabadi Ebrahim Hajizadeh Anoshirvan Kazemnejad Seyed Reza Fatemi

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Colonoscopy screening results in at risk Iranian population.

PubMed (2010)

Seyed Reza Fatemi Sepideh Shivarani Fatemeh Malek Mohsen Vahedi Elham Maserat

To investigate the prevalence of colorectal adenomas and other advanced lesions in first degree relatives of Iranian patients diagnosed with colorectal cancer by colonoscopy and pathologic evaluation.Iranian colorectal cancer patients (probands) were identified through pathologic reports of the regional cancer registry. First degree relatives (siblings, parents and offspring) of probands were evaluated for the existence of polyps and precancerous lesions via colonoscopy screening. Control patients were chosen among average risk population with no family history of colorectal cancer who agreed to colonoscopy screening.A total of 184 subjects underwent colonoscopy screening from April 2007 to March 2009. From 90 cases among families of probands, 70 (77.8%) had a normal colonoscopy result, 18 (20%) demonstrated polyps and 2 (2.2%) were diagnosed with colorectal cancer. Colonoscopy screening in 94 average risk control patients discovered polyps in 4 (4.3%) cases and the other 90 (95.7%) patients had normal total colonoscopy results. Mean age of cases with advanced lesions was 48.4∓10.2 and 41.5∓18.4 in control patients with polyps. The incidence of polyps was significantly higher in males, and in family case patients compared to controls.Based on colonoscopy screening, the prevalence of colorectal adenoma and precancerous lesions in first degree relatives of patients diagnosed with colorectal cancer is significantly higher than in the average risk population.

Proband

First-degree relatives

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