follow-up clinic the results obtained were not far removed from those in healthy adults.The twenty patients with clinical syndromes following surgery for peptic ulcer-that is, recurrent peptic ulceration, afferent or efferent loop hold-up, dumping syndromes, or malabsorptive states-showed evidence of leucocyte ascorbic acid depletion.Patients with duodenal ulcer on admission for surgical management were found to have values similar to those in the subjects with clinical syndromes following operation.Our findings indicate that it is in these patients with symptoms following gastric surgery that ascorbic acid depletion may be expected.-Weare, etc.,
Adult predictive and prenatal testing programmes for Huntington's disease (HD) in Canada have been available since 1986. However, the demand for prenatal testing and the reasons why some people choose not to have the prenatal test for this late onset disorder have not been well documented. In addition, the knowledge and attitudes of adult predictive testing candidates and their partners about prenatal testing are not well known nor are the psychological effects of prenatal testing well understood. As of September 1991, 425 subjects had entered the Canadian Collaborative Study of Predictive Testing and, of these, 47 subjects or their partners had become pregnant. Of this group, 14 (30%) couples requested prenatal testing, 24 (51%) couples did not want prenatal testing, and nine (19%) at risk subjects had already received a decreased risk through adult predictive testing and, therefore, were not eligible for the prenatal test. Of the 14 couples who initially requested prenatal testing, seven withdrew. Thus, demand for the prenatal test by eligible candidates was 7/38 or 18%, which is much lower than the 32 to 65% expected based on early survey data. The most frequently cited reason for declining prenatal testing was the hope that a cure would be found in time for their children. While the majority of adult predictive testing candidates (71%) in our study had accurate information about definitive prenatal testing, many (63%) did not have a correct understanding of exclusion prenatal testing. Although no serious adverse events such as suicide planning or admission to psychiatric hospital have occurred, a particular need for careful counselling was identified for those at risk candidates and their partners who have one prenatal test and feel compelled to use the test again in future pregnancies. Even though prenatal testing for HD is not requested as often originally expected, it still remains a desired option for some at risk persons and their partners.
Abstract The discovery of DNA markers linked to the gene causing Huntington disease (HD) has allowed the development of predictive testing programs for persons at‐risk. A pilot program was established in British Columbia in November 1986. Ninetyfive persons are currently enrolled. The major objective of this project is to introduce and evaluate a protocol for the delivery of test results to persons at‐risk for HD. The criteria for entry and details of the psychosocial assessment before and after receiving a modified risk are presented. The guidelines that are developed from this project will have major applications for predictive testing programs for other late onset autosomal dominant disorders.
Abstract Predictive testing was offered to individuals at‐risk for Huntington disease living within a 100‐mile radius of Vancouver, BC. Ninety‐five at‐risk individuals, representing approximately 12.6% of eligible candidates in this area, have enrolled in its first 16 months. This paper reports on the psychosocial characteristics of the first 51 at‐risk individuals to complete the initial assessment. Two‐thirds of the candidates are female with a mean age 39.3 years. They derive from higher socioeconomic backgrounds. Reasons for taking the test included planning for the future, concern for their children, and reducing uncertainty. Only 29.4% of candidates would both desire prenatal testing and terminate a high‐risk pregnancy. Results on the SCL 90(R), General Well‐Being, and other scales indicate that the candidates' mental health is representative of the population, but as a group, they are more resourceful. The tests identified individuals who needed further assessment on the basis of previous and current psychiatric functioning and social support. No candidate was a high immediate suicidal risk. The process of personal assessment has had beneficial effects on personal growth. The self‐selection of a healthy group of candidates emphasizes the need for continued assessment and support as possibly less healthy candidates register for predictive testing programs in the future.
Journal Article CEREBRAL EFFECTS OF REWARMING FOLLOWING PROLONGED HYPOTHERMIA: SIGNIFICANCE FOR THE MANAGEMENT OF SEVERE CRANIO-CEREBRAL INJURY AND ACUTE PYREXIA Get access MAURICE BLOCH MAURICE BLOCH From the Department of Neurosurgery, St. George's HospitalLondon, S.W.1, and from the Royal Marsden HospitalS.W.3 Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 90, Issue 4, December 1967, Pages 769–784, https://doi.org/10.1093/brain/90.4.769 Published: 01 December 1967
