Mar Vernet

Hospital Del Mar

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Sònia Servitja

Hospital Del Mar

Xavier Castells

Hospital Del Mar

Ana Rodríguez‐Arana

Vall d'Hebron Hospital Universitari

María Sala

Hospital Del Mar

Isabel Torá‐Rocamora

Barcelona Institute for Global Health

Josep Alfons Espinàs

Institut d'Investigació Biomédica de Bellvitge

Marta Román

Hospital Clínico San Carlos

Joana Ferrer

Hospital del Mar Research Institute

Carmen Vidal

Institut d'Investigació Biomédica de Bellvitge

Mar Sánchez

Gobierno de Canarias

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Hospital Del Mar

Hospital del Mar Research Institute

Municipal Institute for Medical Research

Parc de Salut

Universitat Autònoma de Barcelona

Research Network (United States)

Instituto de Salud Carlos III

Spanish Clinical Research Network

Hospital Universitario Fundación Jiménez Díaz

Red de Investigación en Actividades Preventivas y Promoción de la Salud

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Diagnosis and locoregional treatment of patients with breast cancer during the COVID-19 pandemic/ Diagnóstico y tratamiento locorregional de las pacientes con cáncer de mama durante la pandemia de la COVID-19

Ricardo Pardo Manel Algara M. Angeles Montero-Fernandez X. Sanz Mar Vernet

We are facing a pandemic that is going to affect a significant part of the population. At the end of April in the world there are about 3,000,000 cases, with 205,000 deaths and 860,000 patients recovered. The response to this pandemic has in many cases led to a significant change in the daily work of caring for cancer patients, the good results of which depend largely on time-adjusted protocols and multidisciplinary treatments. We present a review of local, surgical and radiotherapy treatment together with authors’ recommendations made from personal experience on ways to act in the diagnosis and surgical treatment of breast cancer during the COVID-19 pandemic. The multidisciplinary Breast Committees must continue to meet weekly in videoconference format. All surgical actions and irradiations must be carried out with maximum safety for both the patients and the participating teams. Hypofractionation in radiation therapy should be the standard treatment. Sometimes it is recommended to apply a primary systemic treatment or even a primary irradiation. Great coordination between the surgical and oncology teams, both medical and radiotherapeutic, is essential.

Pandemic

Radiation oncology

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Changes in mammographic density over time and the risk of breast cancer: An observational cohort study

The Breast (2019)

Marta Román María Sala Marisa Baré Margarita Posso Carmen Vidal

Mammographic Density

Breast density

BI-RADS

Breast Cancer Screening

10.1016/j.breast.2019.04.007

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Citations (19)

Rice Seeds as Biofactories of Rationally Designed and Cell-Penetrating Antifungal PAF Peptides

Frontiers in Plant Science (2019)

Mireia Bundó Xiaoqing Shi Mar Vernet José F. Marcos Belén López‐García

PAFs are short cationic and tryptophan-rich synthetic peptides with cell penetrating antifungal activity. They show potent and selective killing activity against major fungal pathogens, and low toxicity to other eukaryotic and bacterial cells. These properties make them a promising alternative to fulfill the need of novel antifungals with potential applications in crop protection, food preservation and medical therapies. However, the difficulties of cost-effective manufacturing of PAFs by chemical synthesis or biotechnological production in microorganisms have hampered their development for practical use. This work explores the feasibility of using rice seeds as an economical and safe production system of PAFs. The rationally designed PAF102 peptide with improved antifungal properties was selected for assessing PAF biotechnological production. Two different strategies are evaluated: (i) the production as a single peptide targeted to protein bodies; and (ii) the production as an oleosin fusion protein targeted to oil bodies. Both strategies are designed to offer stability to the PAF peptide in the host plant and to facilitate its downstream purification. Our results demonstrate that PAF does not accumulate to detectable levels in rice seeds when produced as a single peptide, whereas it is successfully produced as fusion protein to the Oleosin18, up to 20 µg of peptide per gram of grain. We show that the expression of the chimeric Ole18-PAF102 gene driven by the Ole18 promoter results in the specific accumulation of the fusion protein in the embryo and aleurone layer of the rice seed. Ole18-PAF102 accumulation has no deleterious effects on seed yield, germination capacity, or seedling growth. We also show that the Oleosin18 protein serves as carrier to target the fusion protein to oil bodies facilitating PAF102 recovery. Importantly, the recovered PAF102 is active against the fungal phytopatogen Fusarium proliferatum. Altogether, our results prove that the oleosin fusion technology allows the production of PAF bioactive peptides to assist the exploitation of these antifungal compounds.

Oleosin

Downstream processing

10.3389/fpls.2019.00731

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Citations (11)

Dissemination of health technologies: Trends in the use of diagnostic test in breast cancer screening

Journal of Healthcare Quality Research (2019)

Carmen Natal Ana Fernández‐Somoano Isabel Torá‐Rocamora Carmen Vidal Xavier Castells

Recall rate

Breast Cancer Screening

Cancer Detection

10.1016/j.jhqr.2019.02.007

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Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program

Breast Cancer Research and Treatment (2014)

Xavier Castells Laia Domingo Josep Corominas Isabel Torá‐Rocamora María Jesús Quintana

Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.

Breast disease

Breast Cancer Screening

Atypia

10.1007/s10549-014-3208-z

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Citations (67)

Diagnosis and locoregional treatment of patients with breast cancer during the COVID-19 pandemic

Revista de Senología y Patología Mamaria (2020)

Ricardo Pardo Manel Algara M. Angeles Montero-Fernandez X. Sanz Mar Vernet

Pandemic

10.1016/j.senol.2020.04.002

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Citations (11)

METAPLASTIC CARCINOMA WITH CHONDROID DIFFERENTIATION. PRESENTATION OF THIS RARE TUMOR VARIANT.

European Journal of Surgical Oncology (2023)

Marta Jiménez Gómez Eduardo Luque Paula Masó Pau Bosch‐Nicolau Mar Vernet

Presentation (obstetrics)

10.1016/j.ejso.2022.11.255

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Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain

The Breast Journal (2018)

Marta Román Martı́n Caicoya Josep Alfons Espinàs María Sala Isabel Torá‐Rocamora

Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.

Breast disease

Breast carcinoma

10.1111/tbj.13003

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Citations (1)