Zeqing Wen

Research Field

Human leukocyte antigen-G(HLA-G) is a non-classical human leukocyte class Ⅰb antigen(HLA-Ⅰb) which was observed to be restrictively expressed by the fetal-maternal interface on the extravillous cytotrophoblast.During the last few years,the HLA-G field has evolved from being a topic restricted to reproduction to a very broad topic that spans from transplantation to autoimmunity to oncology.Sixteen types of tumors have been analyzed and it is concluded that the expression of HLA-G is associated with malignant transformation and a down-modulation of the immune response.Based on the information we reviewed,it is proposed that HLA-G whose engagement generates inhibitory signals in various immune cells may represent a mechanism used by tumor cells to escape from immunosurveillance and HLA-G expression may represent a useful prognostic marker in at least some malignant diseases.

Immunosurveillance

HLA-G

Malignant Transformation

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Contents Vol. 32, 2010

American Journal of Nephrology (2010)

Veronika Müller You‐Lin Tain Byron P. Croker Chris Baylis Yibing Fu

10.1159/000322910

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Loss of PP2A and PTEN immunoexpression coexists with survivin overexpression in adenomyosis

Reproductive Biology (2014)

Hui Zhang Jing Liu Xingbo Ζhao Bo-ran Liang Zeqing Wen

Adenomyosis

Tensin

Survivin

10.1016/j.repbio.2014.04.004

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5-Aza-2′-deoxycytidine is a potent inhibitor of DNA methyltransferase 3B and induces apoptosis in human endometrial cancer cell lines with the up-regulation of hMLH1

Medical Oncology (2009)

Min Cui Zeqing Wen Ji Chen Zhongli Yang Hualing Zhang

DNA methyltransferase

10.1007/s12032-009-9204-1

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Endometriotic epithelial cells induce MMPs expression in endometrial stromal cells via an NFкB-dependent pathway

Gynecological Endocrinology (2009)

Hui Zhang Mingjiang Li Fuling Wang Shu Liu Jijun Li

Objective. To explore the stroma–epithelium interactions in endometriosis and to identify the possible signalling pathways involved in this cross-talk.

10.3109/09513590903366988

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Therapy progression about adenomyosis

Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi (2012)

Zeqing Wen

Adenomyosis is a disorder characterized by presence of endometrial glands and stroma within the myometrium.It often occurs in young or middle aged women,and the frequency of it is rising now.It has serious clinical symptoms and causes great bad influence on patient's lives.As imaging and minimally invasive diagnostic methods were pursued and developed,various therapeutic options for adenomyosis,including medical therapies,minimally invasive or non-invasive treatments became available,but they need further evaluation and improvement.Hysterectomy is the ultimate solution for women with deep myometrial involvement or if future fertility is not desired.

Adenomyosis

Myometrium

Medical Therapy

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AN AEROSOL MODEL TO PREDICT SIZE AND STRUCTURE OF SOOT PARTICLES

Journal of Aerosol Science (2004)

S. H. Park Steven N. Rogak W. K. Bushe Zeqing Wen Murray J. Thomson

10.1016/s0021-8502(19)30158-2

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