Jen Tsi Yang

University of California, San Francisco

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Chuen‐Shang C. Wu

University of California, San Francisco

Tatsuya Samejima

University of Electro-Communications

Shigeo Kubota

Kawasaki Hospital

Joseph F. Foster

Shifa Tameer-e-Millat University

Pranab Kumar Sarkar

Assam University

Eisaku Iizuka

Meiji University

Hajime Noguchi

Toho University

Kiyoshi Ikeda

Hiroshima International University

Felicia Gaskin

University of Virginia

Nancy M. Lee

Columbia University

Cooperative Institutions

University of California, San Francisco

National Taiwan University

University of California San Francisco Medical Center

The University of Tokyo

Institute of Biological Chemistry, Academia Sinica

Langley Porter Psychiatric Hospital and Clinics

National Institutes of Health

University of Minnesota

University of Minnesota Medical Center

Harvard University

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Some problems of CD analyses of protein conformation

Analytical Biochemistry (1991)

S.Yu. Venyaminov Igor Baikalov Chuen‐Shang C. Wu Jen Tsi Yang

Dichroic glass

Root mean square

10.1016/0003-2697(91)90421-o

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Citations (31)

Remembrance of Things Past

Springer eBooks (1996)

Jen Tsi Yang

Watson

Globular protein

10.1007/978-1-4757-2508-7_1

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Citations (3)

Conformational stability of porcine serum transferrin

Protein Science (1992)

Zhi Min Shen Jen Tsi Yang You‐Min Feng Chuen‐Shang C. Wu

Abstract The conformation of porcine serum ferric transferrin (Tf) and its stability against denaturation were studied by circular dichroism. Tf was estimated to have 19–24% α ‐helix and 50–55% β‐sheet based on the methods of Chang et al. (Chang, C.T., Wu, C.‐S.C., & Yang, J.T., 1978, Anal. Biochem. 91 , 13–31) and Provencher and Glöckner (Provencher, S.W. & Glöckner, J., 1981, Biochemistry 20 , 33–37). Removal of the bound ferric ions (apo‐Tf) did not alter the overall conformation, but there were subtle changes in local conformation based on its near‐UV CD spectrum. The Tfs were stable between pH 3.5 and 11. Denaturation by guanidine hydrochloride (Gu‐HCl) showed two transitions at 1.6 and 3.4 M denaturant. The process of denaturation by acid and base was reversible, whereas that by Gu‐HCl was partially reversible. The irreversible thermal unfolding of Tfs began at temperatures above 60 °C and was not complete even at 80 °C. The bound irons (based on absorbance at 460 nm) were completely released at pH <4 or in Gu‐HCl solution above 1.7 M, when the protein began to unfold, but they remained intact in neutral solution even at 85 °C. The NH 2‐ and COOH‐terminal halves of the Tf molecule obtained by limited trypsin digestion had CD spectra similar to the spectrum of native Tf, and the COOH‐terminal fragment had more stable secondary structure than the NH 2 ‐terminal fragment.

Denaturation (fissile materials)

Guanidine

Equilibrium unfolding

Hydrochloride

Absorbance

10.1002/pro.5560011109

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Citations (19)

Syntheses and conformational studies of poly(N^ε‐methyl‐L‐lysine), poly(N^δ‐methyl‐L‐ornithine), poly(N^δ‐ethyl‐L‐ornithine), and their carbobenzoxy derivatives

Biopolymers (1974)

Hiroyuki Yamamoto Jen Tsi Yang

Abstract The helix–coil transitions of poly( N ε ‐methyl, N ε ‐carbobenzoxy‐ L ‐lysine), poly( N δ ‐methyl, N δ ‐carbobenzoxy‐ L ‐ornithine), and poly( N δ ‐ethyl, N δ ‐carbobenzoxy‐ L ‐ornithine) in chloroform–dichloroacetic acid and their corresponding decarbobenzoxylated polypeptides in alkaline solutions were followed by optical rotation measurements. The introduction of a methyl or an ethyl group to the side chains of the carbobenzoxy derivatives of poly( L ‐lysine) and poly( L ‐ornithine) appeared to weaken the helical conformation at 25°C. The thermodynamic quantities of the three water‐soluble polypeptides were calculated from the data on potentiometric titrations at several temperatures. For uncharged coil‐to‐helix transition, Δ H = −370 cal/mol and Δ S = −1.1 eu/mol for poly( N ε ‐methyl‐ L ‐lysine), and Δ H = −540 cal/mol and Δ S = −1.6 eu/mol for poly( N δ ‐ethyl‐ L ‐ornithine) (all on molar residue basis). The absolute values of Δ H and Δ S dropped in the region of pH‐induced transition and eventually both quantities became positive. The initiation factor σ was about 2 × 10 −3 , which was essentially independent of temperature. For poly( N δ ‐methyl‐ L ‐ornithine) the coil‐to‐helix transition was not complete even when the polymer was uncharged at high pH.

Dichloroacetic acid

Side chain

Helix (gastropod)

10.1002/bip.1974.360130603

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Citations (12)

Factors Affecting the Non-Newtonian Viscosity of Rigid Particles¹

Journal of the American Chemical Society (1959)

Jen Tsi Yang

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors Affecting the Non-Newtonian Viscosity of Rigid Particles1Jen Tsi YangCite this: J. Am. Chem. Soc. 1959, 81, 15, 3902–3907Publication Date (Print):August 1, 1959Publication History Published online1 May 2002Published inissue 1 August 1959https://pubs.acs.org/doi/10.1021/ja01524a024https://doi.org/10.1021/ja01524a024research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

10.1021/ja01524a024

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Citations (49)

Basic fibroblast growth factor is a β-rich protein

Journal of Protein Chemistry (1991)

Chuen‐Shang C. Wu Stewart A. Thompson Jen Tsi Yang

Antiparallel (mathematics)

Helix (gastropod)

Residue (chemistry)

10.1007/bf01025257

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Citations (14)

Circular Dichroism of the Liquid Crystals of Poly (γ-benzyl-L-glutamate) Under Static Electric Fields

Molecular crystals and liquid crystals (1974)

Eisaku Iizuka Jen Tsi Yang

Abstract Liquid crystals of poly(γ-benzyl-L-glatamate) show circular dichroism (CD) from the benzyl chromophores. In an electric field the shape, magnitude and sign of the spectrum depend on the angle between the applied field and the direction of polarization. The inherent CD is restored after subtraction of the linear dichroism component.

Chromophore

Dichroism

Linear dichroism

10.1080/15421407408083185

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Citations (11)

A graphic method for the determination of particle dimensions from molecular weight and rotary diffusion constant

Archives of Biochemistry and Biophysics (1953)

G.Frederick Hanna Jen Tsi Yang Joseph F. Foster

Constant (computer programming)

Particle (ecology)

10.1016/0003-9861(53)90004-6

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Induced optical activity of chondroitin sulfate c–acridine orange complexes

Biopolymers (1968)

Edward J. Eyring Howard Kraus Jen Tsi Yang

Abstract Chondroitin sulfate C (CSC) and acrdiine orange (AO) formed two types of complexes at neutral pH, depending upon the order of mixing. The induced optical activity of AO was much more pronounced when the polysaccharide was added to dye than the dye to polymer (final concentration of dye was 5 × 10 5 M ). The difference in aggregation of the dye molecules is believed to be responsible for the observed peculiarities. The Cotton effects of the CSC‐to‐dye solution displayed a sharp inversion near 59°C. and the profile at 76°C. was almost a mirror image of that at room temperature. At pH 1.3, however, the order of mixing became unimportant, suggesting that the carboxylate on the polysaccharide way involved more intimately than were sulfates in the peculiarities of the Cotton effects.

Acridine orange

Carboxylate

Methyl orange

10.1002/bip.1968.360060507

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Citations (41)

Optical rotatory dispersion and vacuum ultraviolet circular dichroism of a polysaccharide. .iota.-Carrageenan

Journal of the American Chemical Society (1975)

James S. Balcerski E. S. Pysh G. Chi Chen Jen Tsi Yang

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical rotatory dispersion and vacuum ultraviolet circular dichroism of a polysaccharide. .iota.-CarrageenanJames S. Balcerski, E. S. Pysh, G. Chi Chen, and Jen Tsi YangCite this: J. Am. Chem. Soc. 1975, 97, 21, 6274–6275Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://pubs.acs.org/doi/10.1021/ja00854a071https://doi.org/10.1021/ja00854a071research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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Ultraviolet

10.1021/ja00854a071

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Citations (34)