Yaghoub Amanzadeh

Tehran University of Medical Sciences

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Reza Hajiaghaee

Academic Center for Education, Culture and Research

Mohsen Amini

Tehran University of Medical Sciences

Abdolhossein Miri

Zabol University of Medical Sciences

Homa Hajimehdipoor

Shahid Beheshti University of Medical Sciences

Mohammad Ali Faramarzi

Biotechnology Research Center

Emran Habibi

Mazandaran University of Medical Sciences

Abbas Hadjiakhoo

Seyed Esmaeil Sadat Ebrahimi

Tehran University of Medical Sciences

Mahmoud Ghazi‐Khansari

Tehran University of Medical Sciences

Seyyed-Esmaeal Sadat-Ebrahimi

Tehran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

University of Tehran

Biotechnology Research Center

Pharmaceutical Biotechnology (Czechia)

Institute of Medicinal Plant Development

Mazandaran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Pharmac

Academic Center for Education, Culture and Research

Iranian Research Institute of Plant Protection

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Antimicrobial Effect of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) and Its Main Compounds

International journal of medicinal mushrooms (2014)

Mahdi Vazirian Mohammad Ali Faramarzi Seyed Esmaeil Sadat Ebrahimi H R Monsef Esfahani Nasrin Samadi

Mushrooms are considered one of the richest sources of natural antibiotics, and various species of them inhibit the growth of a wide diversity of microorganisms. Ganoderma lucidum, a well-known medicinal mushroom. has many pharmacological and biological activities including an antimicrobial effect, although few studies have investigated the antibacterial and antifungal effects of its purified compounds. The chemical structure of the purified compounds from the hexane fraction was elucidated as ergosta-7,22-dien-3β-yl acetate, ergosta-5,7,22-trien-3β-yl acetate (isopyrocalciferol acetate), ergosta-7,22-dien-3-one, ergosta-7,22-dien-3β-ol, and ergosta-5,7,22-trien-3β-ol (ergostrol). In addition, the structure of ganodermadiol was demonstrated after purification from the chloroform fraction. The fractions inhibited Gram-positive bacteria and yeast, with minimum inhibitory concentration values of 6.25 mg/mL, but were ineffective against Gram-negative bacteria in the tested concentrations. The results were comparable for isolated compounds, whereas the mixture of ergosta-7,22-dien-3β-yl acetate and isopyrocalciferol acetate was weakly effective against Escherichia coli (minimum inhibitory concentration, 10 mg/mL). It could be assumed that the antimicrobial effect of crude fractions is the consequence of mixing triterpenoid and steroid compounds.

Yeast extract

10.1615/intjmedmushr.v16.i1.70

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New Elaborated Technique for Isolation and Purification of Limonene from Orange Oil

Iranian journal of pharmaceutical sciences (2006)

Yaghoub Amanzadeh Mani Ashrafi Fatemeh Mohammadi

Essential oil of the orange peel which was extracted by hydrodistillation method showed 50 different mono- and sesquiterpenes on GC-MS analysis, in which limonene had the highest percentage (92.4%). Due to various important uses of the compound, a method was developed for isolation and purification of limonene. In this method, for extra purification, a fractional distillation on Vigreux column under 100 mm Hg vacuum was used which resulted in 96.7% purity for limonene. Subsequent chromatography by two different packages of silica gel and active charcoal columns resulted in 99.4% and 99.9 % purity of limonene, respectively.

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Seasonal Variation in the Chemical Composition, Antioxidant Activity and Total Phenolic Content of Teucrium persicum Boiss. Essential Oils

Research Journal of Biological Sciences (2010)

Hamid Reza Monsef-Esf Abdolhossein Miri Mohsen Amini Yaghoub Amanzadeh Abbas Hadjiakhoo

Teucrium

10.3923/rjbsci.2010.492.498

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A new putrescine bisamide phenolic glycoside from the seeds of Lallemantia iberica (M. Bieb.) Fisch. & C. A. Mey

Phytochemistry Letters (2012)

Nafiseh Khosravi Dehaghi Daowan Lai Yaghoub Amanzadeh Seyed Smail Sadat-Ebrahimi Peter Proksch

10.1016/j.phytol.2012.06.013

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Two new xanthone diglycosides from Swertia longifolia Boiss.

Natural Product Research (2006)

Homa Hajimehdipoor Marie‐Geneviève Dijoux‐Franca Anne‐Marie Mariotte Yaghoub Amanzadeh Seyyed-Esmaeal Sadat-Ebrahimi

From aerial parts of Swertia longifolia Boiss., which grows in the north of Iran, five xanthones, two of which in diglycosidic form, were isolated. The structures were confirmed by means of their spectral data as isobellidifolin, bellidin, gentisein, 1,5-dihydroxy-3-methoxy-6-O-primeverosyl xanthone, and 8-hydroxy-3,5-dimethoxy-1-O-primeverosyl xanthone, the latter two of which were new derivatives in the plant kingdom.

Xanthone

Gentianaceae

10.1080/14786410600906319

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Citations (17)

Antioxidant power of Iranian propolis extract

Food Chemistry (2006)

Shiva Mohammadzadeh Mohammad Sharriatpanahi Manoochehr Hamedi Yaghoub Amanzadeh Seyed Esmaeil Sadat Ebrahimi

Propolis

Trolox

10.1016/j.foodchem.2006.09.014

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Comparative Chemical Composition and Antioxidant Properties of the Essential Oils and Aromatic Water from Teucrium persicum Boiss.

PubMed (2012)

Abdolhossein Miri Hamid Reza Monsef-Esfahani Mohsen Amini Yaghoub Amanzadeh Abbas Hadjiakhoondi

The essential oils and aromatic water, known as Arak in traditional Iranian medicine, comes from the aerial part of Teucrium persicum Boiss., which is grown in Fars Province located in Iran. The samples were collected in summer and the oils and aromatic water were obtained through steam distillation. The chemical composition of the oils was analyzed using GC-MS. An analysis of the chemical profile of the isolated oils revealed the presence of more than 80 compounds, mainly oxygenated monoterpenes and sesquiterpene hydrocarbons. The principal components of essential oil were α-cadinene (9.7%), 1,4-cadinadiene (9.2%) and α-terpinyl acetate (7.9%). The major constituents in the Arak were determined to be linalool (10.4%), α-cadinene (7.5%) and γ-terpineol (7.3%). Most of the compounds identified from different oils were similar, but their amounts differed. The oil revealed a higher content of total phenolics than the Arak (1.71 ± 0.12 mg GAE/g DW and 1.36 ± 0.11 mg GAE/g DW, respectively). The antioxidant activity of the oils was calculated by using a ferric reducing antioxidant power assay (FRAP), DPPH radical scavenging activity, and a reducing power assay (RP). The FRAP value points to a considerably higher reducing power of essential oil (220 ± 7.2 µmol Fe(2+)/g DW) compared to that of Arak (113 ± 5.4 µmol Fe(2+)/g DW). Essential oil exhibited higher radical scavenging potential (IC50 = 0.29 mg/mL) than Arak (IC50 = 4.19 mg/mL). The reducing power of essential oil (51.7 ± 4.3 µg BHA/g DW) was higher than that of Arak (34.1 ± 2.7 µg BHA/g DW). The studied essential oils showed good antioxidant activities, which were higher than those of Arak.

Steam distillation

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Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice

Journal of Pharmacy and Pharmacology (2006)

Zhina Sadeghi Sara Elmi Azadeh Elmi Mahmoud Ghazi‐Khansari Homa Hajimehdipoor

Abstract Aerial parts of Swertia longifolia Boiss. (Gentianaceae), which grows in the north of Iran, were screened for hepatoprotective activity against paracetamol (acetaminophen)-induced hepatotoxicity in Swiss mice. Pretreatment with total plant extract and swerchirin, the major component of the plant, significantly reduced the elevation of biochemical parameters, AST (aspartate aminotransferase), ALT (alanine aminotransferase) and ALP (alkaline phosphatase), the enzymes that are increased by liver damage (P < 0.001). Our results indicated that total plant extract and swerchirin were hepatoprotective in the range of 6–50 mg kg−1 orally.

10.1211/jpp.58.2.0017

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Citations (28)

Volatile Constituents of the Aerial Parts ofCymbopogon olivieri(Boiss.) Bor. From Iran

Journal of Essential Oil Bearing Plants (2003)

Ali Asadipour Zahra Rezaei Siroos Saberi- Amoli Yaghoub Amanzadeh Alireza Ghannadi

Abstract The volatile oil obtained in 1.3% yield by hydrodistillation of the aerial parts of Cymbopogon olivieri (Boiss.) Bor. growen in kerman parovince, Iran was investigated by GC and GC-MS. Fifteen components were detected, representing 93.5% of the total oil. Piperitone (61.0%) and β-caryophyllene (14.4%) were the major constituents of the oil.

10.1080/0972-060x.2003.10643329

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Anti-inflammatory and analgesic activity ofAlkanna bracteosaandAlkanna tricophila

Natural Product Research (2011)

Saber Zare Mahmoudi Mohammad Seyedabadi H R Monsef Esfahani Yaghoub Amanzadeh Seyed Nasser Ostad

Alkanna bracteosa and Alkanna tricophila, Boraginaceae, have been reported to be useful for their anti-inflammatory and wound-healing effects in traditional medicine. Methanol extracts of A. bracteosa and A. tricophila were evaluated for their potential analgesic and anti-inflammatory properties. Alkanna bracteosa was observed to produce a maximum of 42% reduction of hind paw licking in acute as well as 68% alleviation in inflammatory phase of formalin test in mice and about 30% declination of carrageenan-induced rats paw swelling at doses 100-400 mg kg⁻¹ in comparison to negative control; on the other hand, A. tricophila required at least 200 mg kg⁻¹ to exhibit a significant reduction in paw licking or oedemas at the early phase of formalin test and the late phase of carrageenan test, respectively. Our results suggest that the extracts may be of use for their analgesic and anti-inflammatory effects.

Licking

Carrageenan

Anti-inflammatory

10.1080/14786419.2010.532795

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Citations (9)