Elizabeth C. Rowe

Brown University

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ChemInform Abstract: Synthesis and anti‐HIV‐1 Activities of 6‐Arylthio and 6‐ Arylselenoacyclonucleosides

ChemInform (1995)

Bai‐Chuan Pan Z.‐H. CHEN Giovanna Piras Ginger E. Dutschman Elizabeth C. Rowe

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199511279

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Synthesis of variants of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Journal of Heterocyclic Chemistry (1986)

Shih‐Hsi Chu Zhihao Chen Zum‐Yao Weng Elizabeth C. Rowe Edward Chu

Abstract A number of variations and derivatives of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacy‐clouridine), potent inhibitors of uridine phosphorylase were synthesized for evaluation as potential cancer chemotherapeutic agents. (“Acyclo” = 2′‐hydroxymethoxymethyl‐). These included a modification of the methylene group at N‐1, esters of the terminal hydroxyl of the acyclo group, and extension of the benzyl chain at position 5 of the uracil base. BBBAU was a very good potentiator of FUdR in cell culture.

Potentiator

Uracil

Methylene

10.1002/jhet.5570230609

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Citations (6)

The effects of growth conditions on the esterases of Paramecium aurelia

Biochemical Genetics (1971)

Elizabeth C. Rowe Ian Gıbson Alan Cavill

Paramecium aurelia

Esterase

Axenic

Axenic culture

10.1007/bf00485642

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Citations (24)

Synthesis of 5-Benzyl and 5-Benzyloxybenzyl 2,2′-Anhydrouridines and Related Nucleoside Analogs as Inhibitors of Uridine Phosphorylase

Nucleosides and Nucleotides (1988)

Shih Hsi Chu Zum Yao Weng Zhi Hao Chen Elizabeth C. Rowe Edward Chu

Abstract Furanosyl analogs of BAU (5-benzylacyclouridine) and BBAU (5-benzyloxybenzylacyclouridine), two potent inhibitors of uridine phosphorylase, were synthesized and evaluated as potential cancer chemotherapeutic agents. The analogs included ribosides, 2,2′-anhydro nucleosides, arabinosides and deoxyribosides. The anhydrouridine intermediates were potent inhibitors of uridine phosphorylase and good potentiators of FdUrd activity in human tumor cells in culture.

Potentiator

Thymidine phosphorylase

Nucleotide salvage

Nucleoside analogue

10.1080/07328318808068705

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Citations (18)

Synthesis of 5‐benzyl and 5‐benzyloxybenzyl‐3′‐azido‐2′,3′‐dideoxyuridine and their analogues as potential anti‐AIDS agents

Journal of Heterocyclic Chemistry (1990)

Bai‐Chuan Pan Zum‐Yao Weng Zhihao Chen Elizabeth C. Rowe Shih‐Hsi Chu

Abstract 5‐Benzyl and 5‐benzyloxybenzyl‐substituted 3′‐azido‐2′,3′‐dideoxyuridine, ( 8a and 8b ), 3′‐halogeno‐2′,3′‐dideoxyuridine, 9a, 9b, 10a, 10b, 11a and 11b , and 2′,3′‐dideoxyuridine, 12a and 12b , of Scheme I were synthesized as potential anti AIDS agents. Synthesis of epimers of 8a and 8b , 5‐benzyl‐ and 5‐benzyloxybenzyl‐1‐(3′‐azido‐2′,3′‐dideoxy‐β‐D‐threo‐pentafuranosyl)uracil, 15a and 15b , and 5‐benzyl‐ and 5‐benzyloxy‐5′‐azido‐2′,5′‐dideoxyuridine, 16a and 16b , shown in Scheme II, were also reported.

Epimer

Uracil

10.1002/jhet.5570270609

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Citations (3)

Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Journal of Heterocyclic Chemistry (1987)

Shih Hsi Chu Zhi Hao Chen Zun Yao Weng Elizabeth C. Rowe Edward Chu

Abstract Amino analogs of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) and their 2′‐hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti‐tumor action of FUdR.

Potentiator

Hydroxymethyl

10.1002/jhet.5570240418

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Citations (9)

Synthesis And Biological Activity Op Hydpdxymetflyl Analogs op 5-Benzylacyclouridine and 5-Benzyloxybenzylacycloaridine

Nucleosides and Nucleotides (1984)

Shih Hsi Chu Zhi Hao Chen Elizabeth C. Rowe Fardos N.M. Naguib Hahmoud H. el Kouni

Abstract Hydroxymethyl analogs of 5-benzylacyclouridine (BAU) and 5-benzyloxybenzylacyclouridine (BBAU) were synthesized by the condensation of appropriately blocked 2-(chloromethyl)glycerols with substituted 2, 4-dimethoxypyrimidines. The HM derivatives were found to be potent inhibitors of the enzyme uridine phosphorylase and to potentiate significantly the growth-inhibiting action of FdUrd in cell culture.

Hydroxymethyl

10.1080/07328318408081267

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Citations (21)

ChemInform Abstract: Synthesis of Variants of 5‐Benzylacyclouridine and 5‐Benzyloxybenzylacyclouridine.

ChemInform (1987)

S. Haihua Chu Z.‐H. CHEN Zum Yao Weng Elizabeth C. Rowe Edward Chu

Abstract The chloroethyl ether (III), obtained from (I) and the aldehyde (II), is coupled with the dimethoxypyrimidines (IV) in the presence of hexamethyldisilazane to give the substitution products (V) which are hydrolyzed, forming (VI).

Substitution (logic)

10.1002/chin.198729203

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Citations (0)

ChemInform Abstract: Synthesis of Aminomethyl and Amino Analogs of 5‐Benzylacyclouridine and 5‐Benzyloxybenzylacyclouridine.

ChemInform (1988)

S. Haihua Chu Z. H. Chen Zhenzhao Weng Elizabeth C. Rowe Edward Chu

Abstract The N‐hydroxyalkyl phthalimides (I) are converted to the chloromethyl ethers (III).

10.1002/chin.198807230

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ChemInform Abstract: Synthesis of Some Halogenated and Disubstituted Amino Benzylacyclouridine Derivatives.

ChemInform (1992)

Bai‐Chuan Pan Z.‐H. CHEN Elizabeth C. Rowe S. Haihua Chu

10.1002/chin.199248280

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