Simon Biron

Université Laval

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Simon Marceau

Université Laval

Laurent Biertho

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Stéfane Lebel

Montreal Heart Institute

Odette Lescelleur

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Picard Marceau

Montreal Heart Institute

Frédéric‐Simon Hould

Institut Universitaire de Cardiologie et de Pneumologie de Québec

André Tchernof

Université Laval

Marie‐Claude Vohl

Université Laval

Paul Poirier

Université Laval

Serge Simard

Université Laval

Cooperative Institutions

Quebec Rehabilitation Research Network

108

Université Laval

103

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Montreal Heart Institute

Université de Montréal

Lung Institute

Université de Sherbrooke

Centre hospitalier universitaire de Québec

Centre hospitalier de l'Université Laval

Harvard University

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Characterization of Dedifferentiating Human Mature Adipocytes from the Visceral and Subcutaneous Fat Compartments: Fibroblast-Activation Protein Alpha and Dipeptidyl Peptidase 4 as Major Components of Matrix Remodeling

PLoS ONE (2015)

Julie Lessard Mélissa Pelletier Laurent Biertho Simon Biron Simon Marceau

Mature adipocytes can reverse their phenotype to become fibroblast-like cells. This is achieved by ceiling culture and the resulting cells, called dedifferentiated fat (DFAT) cells, are multipotent. Beyond the potential value of these cells for regenerative medicine, the dedifferentiation process itself raises many questions about cellular plasticity and the pathways implicated in cell behavior. This work has been performed with the objective of obtaining new information on adipocyte dedifferentiation, especially pertaining to new targets that may be involved in cellular fate changes. To do so, omental and subcutaneous mature adipocytes sampled from severely obese subjects have been dedifferentiated by ceiling culture. An experimental design with various time points along the dedifferentiation process has been utilized to better understand this process. Cell size, gene and protein expression as well as cytokine secretion were investigated. Il-6, IL-8, SerpinE1 and VEGF secretion were increased during dedifferentiation, whereas MIF-1 secretion was transiently increased. A marked decrease in expression of mature adipocyte transcripts (PPARγ2, C/EBPα, LPL and Adiponectin) was detected early in the process. In addition, some matrix remodeling transcripts (FAP, DPP4, MMP1 and TGFβ1) were rapidly and strongly up-regulated. FAP and DPP4 proteins were simultaneously induced in dedifferentiating mature adipocytes supporting a potential role for these enzymes in adipose tissue remodeling and cell plasticity.

10.1371/journal.pone.0122065

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Citations (52)

Anatomical distribution of primary amine oxidase activity in four adipose depots and plasma of severely obese women with or without a dysmetabolic profile

Journal of Physiology and Biochemistry (2016)

Christian Carpéné Francisco Les Mounia Hasnaoui Simon Biron Picard Marceau

Amine oxidase (copper-containing)

10.1007/s13105-016-0526-0

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Citations (15)

Waist Circumference is Useless to Assess the Prevalence of Metabolic Abnormalities in Severely Obese Women

Obesity Surgery (2007)

Vicky Drapeau Isabelle Lemieux Denis Richard Jean Bergeron Angelo Tremblay

Circumference

Abdominal obesity

10.1007/s11695-007-9168-1

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Citations (33)

Twenty Years of Biliopancreatic Diversion: What is the Goal of the Surgery?

Obesity Surgery (2004)

Simon Biron Frédéric‐Simon Hould Stéfane Lebel Simon Marceau Odette Lescelleur

Biliopancreatic Diversion

Severe obesity

10.1381/096089204322857492

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Citations (157)

LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes

Clinical Epigenetics (2012)

Valérie Turcot André Tchernof Yves Deshaies Louis Pérusse Alexandre Bélisle

Epigenetic mechanisms may be involved in the regulation of genes found to be differentially expressed in the visceral adipose tissue (VAT) of severely obese subjects with (MetS+) versus without (MetS-) metabolic syndrome (MetS). Long interspersed nuclear element 1 (LINE-1) elements DNA methylation levels (%meth) in blood, a marker of global DNA methylation, have recently been associated with fasting glucose, blood lipids, heart diseases and stroke.To test whether LINE-1%meth levels in VAT are associated with MetS phenotypes and whether they can predict MetS risk in severely obese individuals.DNA was extracted from VAT of 34 men (MetS-: n = 14, MetS+: n = 20) and 152 premenopausal women (MetS-: n = 84; MetS+: n = 68) undergoing biliopancreatic diversion for the treatment of obesity. LINE-1%meth levels were assessed by pyrosequencing of sodium bisulfite-treated DNA.The mean LINE-1%meth in VAT was of 75.8% (SD = 3.0%). Multiple linear regression analyses revealed that LINE-1%meth was negatively associated with fasting glucose levels (β = -0.04; P = 0.03), diastolic blood pressure (β = -0.65; P = 0.03) and MetS status (β = -0.04; P = 0.004) after adjustments for the effects of age, sex, waist circumference (except for MetS status) and smoking. While dividing subjects into quartiles based on their LINE-1%meth (Q1 to Q4: lower %meth to higher %meth levels), greater risk were observed in the first (Q1: odds ratio (OR) = 4.37, P = 0.004) and the second (Q2: OR = 4.76, P = 0.002) quartiles compared to Q4 (1.00) when adjusting for age, sex and smoking.These results suggest that lower global DNA methylation, assessed by LINE-1 repetitive elements methylation analysis, would be associated with a greater risk for MetS in the presence of obesity.

Quartile

Meth-

10.1186/1868-7083-4-10

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Citations (71)

34 Laparoscopic Malabsorption Procedures: Management of Surgical Complications

Springer eBooks (2014)

Fady Moustarah Frédéric‐Simon Hould Simon Marceau Simon Biron

10.1007/978-1-4939-1637-5_34

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Citations (0)

Obesity Surgery (2006)

Karine Duval Picard Marceau Odette Lescelleur Frédéric‐Simon Hould Simon Marceau

10.1381/096089206776944968

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Citations (61)

Impact of bariatric surgery on cardiac structure, function and clinical manifestations in morbid obesity

Expert Review of Cardiovascular Therapy (2004)

Paul Poirier Julie Martin Picard Marceau Simon Biron Simon Marceau

Obesity results from the excessive accumulation of fat. Risk of premature death is doubled compared to nonobese individuals, and risk of death from cardiovascular disease is increased fivefold. In patients with morbid obesity, a variety of adaptations and alterations in cardiac structure and function occur in the individual, as an excess amount of adipose tissue accumulates. The high long-term failure rate of diet intervention is well acknowledged by the clinician. Surgery for severe obesity has evolved during the last 40 years. Many surgical techniques have been described and abandoned. Nevertheless, numerous different techniques are still in use today. Weight loss has beneficial impacts on functional and structural cardiac status and will be reviewed in this report.

10.1586/14779072.2.2.193

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Citations (53)

Long-Term Metabolic Outcomes 5 to 20 Years After Biliopancreatic Diversion

Obesity Surgery (2015)

Picard Marceau Simon Biron Simon Marceau Frédéric‐Simon Hould Stéfane Lebel

Biliopancreatic Diversion

Duodenal switch

Dyslipidemia

10.1007/s11695-015-1599-5

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Citations (141)