Cannabis is the main illicit psychoactive substance used by pregnant women in France. The aim of the present national survey was to describe adverse events (AEs) of recreational cannabis use during pregnancy reported to the French Addictovigilance Network (FAN). Spontaneous reports (SRs) of AEs related to recreational cannabis use during pregnancy were collected by the FAN between 01/01/2011 and 31/01/2021 (excluding cannabidiol and synthetic cannabinoids). Over the study period, 160 SRs involved cannabis use alone or in association with tobacco (59% of all SRs) which increased. Among the 175 maternal AEs, the most commons were psychiatric AEs experienced by 96 (64.9%) women, in particular cannabis use disorders (n = 89, 60.1%), dependence (n = 54, 36.5%) and abuse (n = 21, 14.2%). Among the 57 fetal AEs, the most common were heart rhythm disorders that affected 25 (16.9%) fetuses and intrauterine growth restriction (IUGR) (n = 20, 13.5%). Among the 140 neonatal AEs, the most common were IUGR experienced by 39 (26.3%) newborns and prematurity (n = 32, 21.6%). Twelve cases of congenital malformations were observed and 4 intrauterine/neonatal deaths. Furthermore, some of these AEs (n = 13) were unexpected. Cannabis use during pregnancy has problematic consequences for both mothers and infants who need close monitoring.

Intrauterine growth restriction

Recreational Drug

10.1038/s41598-022-19197-2

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Iconography : The French Levothyrox ® crisis: We did the best we could but…

Stéphane Mouly Matthieu Roustit Haleh Bagheri Marie‐Christine Pérault‐Pochat Mathiéu Molimard

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Arrêt cardiaque récupéré sous varénicline : à propos d’un cas

Therapies (2009)

Guillaume Montastruc Bruno Degand Jean‐Louis Montastruc Marie‐Christine Pérault‐Pochat

Varenicline

10.2515/therapie/2009005

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P3–094: Deficit of emotional memory correlates with levels of the kinase p70S6k in lymphocytes of patients with Alzheimer disease

Alzheimer s & Dementia (2006)

Marie‐Christine Pérault‐Pochat Marc Paccalin Fuad Al Khidir Claudette Pluchon Stéphanie Pain

Alzheimer Disease (AD) is characterized by memory disturbances affecting explicit memory. The molecular process of learning and memory seems to implicate protein synthesis and its control includes the mTOR/p70S6k signaling pathway. These two processes are modified in the brain of AD patients. We have previously shown that levels of the kinase p70S6k in peripheral lymphocytes were correlated with memory and cognitive deficits in patients with AD (Lafay et al J Neurochem 2005, Paccalin et al Arch Int Med 2005). Emotional memory is also disturbed in AD but seems to better resist than neutral explicit memory to the neurodegenerative process. The goal of the study was to assess the difference between emotional and neutral explicit memories (emotional delta) and to correlate these results with levels of the ratio between phosphorylated and total p70S6k in lymphocytes of patients with AD. Twenty eight AD patients were enrolled in this study. MMSE scores ranged from 25 to 10. Explicit memory was assessed in all patients with the Gröber and Buschke (GB) test. Total recall tests for emotional memory (emotional words) and neutral memory (neutral words) were carried out by patients and at the same time blood lymphocytes were extracted and the ratio between phosphorylated and total p70S6k were evaluated in the same patients using western blots. The Pearson correlation test was used for statistical analysis. The results showed: 1–MMSE scores were positively correlated with activated p70S6k levels (p<.001), 2–GB test scores were correlated with p70S6klevels (p<.01), 3–Emotional deltas were also positively correlated with the ratio between phosphorylated and total p70S6k (p<.05). Our results demonstrate that levels of peripheral and activated p70S6k are also a good marker for the evolution of emotional memory in AD as shown for the explicit memory, language and working memory.

Emotional Memory

Memory Impairment

10.1016/j.jalz.2006.05.1361

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