Aron Jacob

Indian Veterinary Research Institute

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Shyam Sundar Choudhary

National Research Centre on Camel

Sahadeb Dey

Indian Veterinary Research Institute

Sujoy K. Dhara

Indian Veterinary Research Institute

Tresamol Pv

B.S. Pruthvishree

Indian Veterinary Research Institute

Neeraj Thakur

Banaras Hindu University

M. Sreelekshmy

Ayushi Saxena

California Institute of Behavioral Neurosciences and Psychology (United States)

Saseendranath Mr

Dileep Kumar Sharma

Chitkara University

Cooperative Institutions

Indian Veterinary Research Institute

Indian Council of Agricultural Research

Banaras Hindu University

King George's Medical University

University of Georgia

California Institute of Behavioral Neurosciences and Psychology (United States)

Sardar Patel Medical College

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Chitkara University

REVA University

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Cucumis callosus (Rottl.) Cogn. fruit extract ameliorates calcium oxalate urolithiasis in ethylene glycol induced hyperoxaluric Rat model

Heliyon (2023)

Shyam Sundar Choudhary Padma Nibash Panigrahi Sujoy K. Dhara Monalisa Sahoo Ananya Dan

Cucumis callosus dry fruits are traditionally used as folk remedy to treat conditions like urethral irritations, urine stoppage or dribbling and other urinary ailments of man in north-west India. But no study is reported to validate this ethnic practice of using Cucumis fruit in urolithiasis. To evaluate anti-urolithiatic potential of Cucumis, hyperoxaluria was induced in rats by supplying 0.75% ethylene glycol (EG) + 1% ammonium chloride (AC) in drinking water for 14 days. Anti-urolithiatic activity of Cucumis callosus hydro-ethanolic extract (CCHEE) was assessed by measuring blood and urine biochemical parameters, oxidative stress indices, histopathology and osteopontin (OPN) expression. Administration of EG-AC to rats caused hyperoxaluria, crystalluria, azotaemia, oxidant/antioxidant imbalance (increase in lipid peroxidation (LPO), and decrease in glutathione (GSH) and catalase (CAT)), up-regulation of OPN and calcium oxalate (CaOx) crystal deposition in kidney. Treatment of afflicted rats with Cucumis fruits extract restored renal function to a great extent (CCHEE group), testified by improvement of stated parameters. Findings demonstrate curative efficacy of Cucumis fruit extract in EG induced urolithiasis of rats. The restoration of renal function was possibly by regulating renal stone formation via reducing urinary oxalate excretion, correcting oxidant/antioxidant imbalances, and reduced expression of OPN. Hence, results of this study validate the ethnic practice of using Cucumis fruit and conclude that fruit extracts have beneficial effects on CaOx urolithiasis and renal function.

Cucumis

10.1016/j.heliyon.2023.e14043

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Citations (6)

Epidemiologic evaluation of urolithiasis in Bareilly area of Uttar Pradesh, India

Biological Rhythm Research (2018)

Neeraj S. Thakur Sahadeb Dey Medram Verma Aron Jacob Shyam Sundar Choudhary

The present study was undertaken to record the prevalence of urolithiasis in buffalo calves, caprine and canine at Referral Veterinary Polyclinic, of Indian Veterinary Research Institute. Different epidemiological parameters like age, sex, and castration status, feeding status were recorded. Animals presented with signs of urolithiasis like dysuria, anuria, urinary incontinence, abdominal pain, tensed abdomen were included in this study. Urolithiasis was confirmed by ultrasonography and urine microscopy before inclusion in the present research. Incidence rate was highest in the month of January (13.93%) and lowest in October (2.57%). The disease is most prevalent between October and February in every year. Prevalence was highest in the year 2015 (6.99%) and lowest in 2016 (5.96%). Among the various species, bovine (buffalo calves) were affected the most, followed by caprine and canine. Female:Male ratio among affected animals was 1:56, 1:81 and 1:10 among bovine (buffalo calves), caprine and canine, respectively. Animals were fed solely on bran diet. Incidence of urolithiasis was higher in animals castrated at early age.

Dysuria

Prevalence

10.1080/09291016.2018.1537547

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A case of concurrent pulmonary and renal cell carcinomas in a German shepherd dog

Indian Journal of Veterinary Pathology (2018)

M. Karikalan M. Sreelekshmy Aron Jacob Dileep Kumar Sharma Krishnan Mahendran

German Shepherd Dog

10.5958/0973-970x.2018.00029.9

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NHS plans leave ‘anonymous’ medical records vulnerable

The New Scientist (2014)

Aron Jacob

Medical record

10.1016/s0262-4079(14)60371-7

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Cytological and Microbiological Evaluation of Nasal Lavage of Calves Naturally Infected with Bovine Respiratory Disease

Journal of Immunology and Immunopathology (2018)

A.G. Bhanuprakash Vivek Joshi V. K. Gupta O.R. Vinodh Kumar Aron Jacob

Bovine Respiratory Disease

10.5958/0973-9149.2018.00006.0

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Comparison of two cow side tests for diagnosis of subclinical mastitis in cows

Deleted Journal (2019)

Tresamol Pv Ratheesh Rl Aron Jacob Saseendranath Mr

Bovine mastitis remains as the major infectious disease that affects dairy cattle throughout the world and results in considerable economic losses to dairy farmers. The present study was undertaken to screen dairy cattle of two organized farms using two cow side tests such as electrical conductivity test and the widely used California Mastitis Test. A total of 261 Quarter milk samples from 77 cows were screened cow side for subclinical mastitis using California Mastitis Test (CMT) and electrical conductivity meter (EC). Correlation between the CMT score and corresponding conductivity was analyzed and the use of EC as an alternative in screening of subclinical mastitis is discussed.

California mastitis test

Subclinical infection

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Citations (1)