Janneke J. van der Heijden-Spek

Maastricht University

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Jan A. Staessen

KU Leuven

Luc M. Van Bortel

Ghent University

Arnold P.G. Hoeks

Maastricht University Medical Centre

Floris Vanmolkot

Maastricht University Medical Centre

Elisabeth J. Balkestein

Maastricht University

Harry A. Struijker Boudier

Maastricht University

Coen D.A. Stehouwer

Maastricht University

J.W. Vredeveld

Atrium Medisch Centrum Parkstad

Cristina Barlassina

University of Milan

Stefan-Martin Herrmann

University of Münster

Cooperative Institutions

Maastricht University

KU Leuven

Maastricht University Medical Centre

Ghent University

University Medical Center Utrecht

Inserm

Erasmus University Rotterdam

Shanghai Institute of Hypertension

Erasmus MC

University Medical Center

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Does B-mode common carotid artery intima-media thickness differ from M-model?

Ultrasound in Medicine & Biology (2001)

Luc M. Van Bortel Floris Vanmolkot Janneke J. van der Heijden-Spek Marsel Bregu Jan A. Staessen

Intima-media thickness

Concordance

Tunica media

10.1016/s0301-5629(01)00448-3

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Citations (27)

Effect of Age on Brachial Artery Wall Properties Differs From the Aorta and Is Gender Dependent

Hypertension (2000)

Janneke J. van der Heijden-Spek Jan A. Staessen Robert Fagard Arnold P.G. Hoeks Harry A. Struijker Boudier

Abstract —Compliance and distensibility are wall properties of large arteries, which may play a role in cardiovascular disease. The purpose of this study was to investigate whether the influence of age on these vessel wall properties differs between vascular territories and is gender-dependent. In a population sample of 498 men and women 20 to 79 years of age, diameter, distensibility, and compliance coefficient of the muscular brachial artery were measured with an echo-tracking device. Distensibility of the aorta was measured with the use of pulse-wave velocity. The effects of age and gender were assessed and adjusted for confounding factors such as mean blood pressure, pulse rate, body mass index, smoking, alcohol intake, and antihypertensive treatment. Covariance analysis showed no relation between gender and distensibility of the elastic aorta. Distensibility of the muscular brachial artery was lower in men, whereas men had a larger diameter and larger compliance of the brachial artery. With age, distensibility of the aorta decreased in both sexes to the same extent, whereas distensibility of the brachial artery did not change significantly. With age, brachial artery diameter increased; this increase was more pronounced in women. In men brachial artery compliance did not change with age, whereas in women compliance of the brachial artery increased with age. This study (1) confirms that distensibility of the aorta, an elastic artery, decreases with age. (2) In contrast to the aorta, after adjustment for confounding factors, in both men and women, no relation exists between age and distensibility of the muscular brachial artery. (3) Brachial artery diameter increase with age is more pronounced in women than in men. (4) In contrast to the well-known decrease in arterial compliance of elastic arteries with age, brachial artery compliance is not decreased with age and is increased in women. In conclusion, the effect of age on large-artery wall properties is not uniform but depends on gender and vascular territory.

Brachial artery

10.1161/01.hyp.35.2.637

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Non-invasive assessment of local arterial pulse pressure: comparison of applanation tonometry and echo-tracking

Journal of Hypertension (2001)

Luc M. Van Bortel Elisabeth J. Balkestein Janneke J. van der Heijden-Spek Floris Vanmolkot Jan A. Staessen

Pulse pressure is not constant throughout the arterial tree. Use of pulse pressure at one arterial site as surrogate for pulse pressure at another arterial site may be erroneous. The present study compares three non-invasive techniques to measure local pulse pressure: (i) internally calibrated readings from applanation tonometry, (ii) alternative calibration of pressure waves obtained with applanation tonometry and (iii) alternative calibration of arterial distension waves obtained with echo-tracking. Alternative calibration assumes mean and diastolic blood pressure constant throughout the large artery tree.Study 1 used invasive measurements in the ascending aorta as a reference method and internally calibrated tonometer readings and alternatively calibrated pressure waves at the common carotid artery as test methods. Study 2 used alternatively calibrated pressure waves as a reference method and alternatively calibrated distension waves and internally calibrated applanation tonometer readings as test methods.In study 1, pulse pressure from internally calibrated tonometer readings was 10.2+/-14.3 mmHg lower and pulse pressure from alternatively calibrated pressure waves was 1.8+/-5.2 mmHg higher than invasive pulse pressure. Pulse pressure from calibrated distension waves was 3.4+/-6.9 mmHg lower than pulse pressure from alternatively calibrated pressure waves. According to British Hypertension Society criteria, pulse pressure from the internally calibrated tonometer achieved grade D and pulse pressure from alternatively calibrated pressure waves achieved grade A. Pulse pressure from calibrated distension waves achieved grade B when alternatively calibrated pressure waves were used as a reference method.Pulse pressure obtained from alternatively calibrated tonometer-derived pressure waves and echo-tracking-derived distension waves demonstrates good accuracy. Accuracy of pulse pressure from internally calibrated applanation tonometer readings at the carotid artery is poor.

Pulse pressure

Applanation tonometry

Arterial tree

Pressure measurement

10.1097/00004872-200106000-00007

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Citations (381)

Large artery properties and cardiovascular risk : a population study

Janneke J. van der Heijden-Spek

10.26481/dis.20001116jh

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Citations (1)

Autonomic nervous function, arterial stiffness and blood pressure in patients with Type I diabetes mellitus and normal urinary albumin excretion

Journal of Human Hypertension (2004)

Frans J. van Ittersum Miranda T. Schram Janneke J. van der Heijden-Spek L.M.A.B. Van Bortel J.W.F. Elte

Pulse pressure

10.1038/sj.jhh.1001751

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Citations (39)

Carotid and Femoral Artery Stiffness in Relation to Three Candidate Genes in a White Population

Hypertension (2001)

Elisabeth J. Balkestein Jan A. Staessen Ji‐Guang Wang Janneke J. van der Heijden-Spek Luc M. Van Bortel

Different genetic polymorphisms influence cardiovascular disease. We recently discovered a relationship between the intima-media thickness of the muscular femoral artery, but not the elastic common carotid artery, and the combined ACE (ACE, I/D), alpha-adducin (Gly460Trp),and aldosterone synthase (AS, C-344T) gene polymorphisms. To investigate the relationship between these polymorphisms and functional properties of the carotid artery and femoral artery, a sample of 756 subjects enrolled in a population study were genotyped for the presence of the ACE D, alpha-adducin 460Trp, and aldosterone synthase -344T alleles. Vessel wall properties were assessed using a vessel wall movement detector system in combination with applanation tonometry. Statistical analysis allowed for confounders and interaction among genes. Cross-sectional compliance of the common carotid artery was negatively associated with the ACE D allele. ACE II versus ACE DD homozygotes differed, expressed as a percentage of the population mean (7.0%; 95% confidence interval [CI], 1.6% to 12.4%; P=0.02). In multigene analysis, ACE DD subjects also deviated significantly from the population mean for the distensibility coefficient of the common carotid artery when carrying the AS/T allele (-5.5%; 95% CI, -9.3% to -1.7%; P<0.01), without a change in cross-sectional compliance. ACE DD subjects, when homozygote for alpha-adducin Gly460, had a lower femoral cross-sectional compliance (-10.4%; 95% CI, -1.9% to -18.9%; P<0.03) and a lower distensibility (-9.7%; 95% CI, -2.1% to -17.3%; P<0.02) compared with the population mean. These data show that functional large artery properties are influenced by the ACE I/D polymorphism. Cross-sectional compliance and distensibility coefficients are influenced by the ACE I/D genotype, but this influence depends on the vascular territory and genetic background.

Brachial artery

10.1161/hy1101.095992

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Citations (92)