The sclerosing hemangioma of the lung is a rare benign tumor. Its histogenesis has not been explained yet. Following the electron-microscopic and immunohistochemical researches, the opinions have been still unhomogeneous. Therefore, it is concluded that is a tumor of epithelial, endothelial, mesenchymal and even mesothelial origin. This study deals with this tumor. Its immunohistochemical analysis points at its epithelial character.
Two cases of hemangiopericytomas, localized in the mediastinum and lung were described. In the former case the tumour was operated 19 years ago and later three relapses of the disease occurred. Today the patient is well without signs of the tumour. In the second case there was no relapse 6 years after the operation. The biological behaviour of hemangiopericytomas cannot be predicted on the basis of the clinical and morphological signs.
PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.
The authors compared the diagnoses from intraoperative frozen section consultation with the final diagnosis using permanent tissue sections from 179 breast biopsy specimens. Of these, there were 175 correct diagnoses (97.8%), two diagnoses were incorrect (1.1%) and two were inconclusive (1.1%). The distribution of the correct diagnoses within each particular group of breast diseases proves that in the invasive tumor group the diagnosis on FS was correct for 101 patients (98.1%) and incorrect for two patients (1.9%). In the fibrocystic breast disease group, diagnoses correlated for 42 patients (97.7%), whereas the problem in diagnosing the extent of epithelial proliferation appeared for only one patient (2.3%) and was categorized as an inconclusive diagnosis. Of 4 incorrect and inconclusive diagnoses, two occurred as a result of sampling nonrepresentative tissue specimens and two as a result of diagnostic misinterpretation. This study has shown that for the determination of the histological type of carcinoma, FS is not of significant morphological value since correct diagnoses were made for only 60% of the patients.
The silver staining technique that identifies NORs (nucleolar organizer regions) associated proteins was used for examining changes in nucleolar organizer region numbers in transitional cell carcinoma of the bladder. This method reveals NORs as black dots in the cell nuclei, and the number of NORs per cell (NORs/cell) has been taught to be related to cellular activation and to be a possible predictor of clinical outcome. A hundred specimens of transitional cell carcinoma of the bladder divided into four histologic grades (Ash classification) with 25 specimens each, and 25 specimens of normal bladder mucosa were analyzed. It has been demonstrated that the amount of protein synthesized by carcinoma varies according to its histologic grade, i.e. the higher histologic grade, the greater the NORs/cell number for each histologic grade. The characteristic mean NORs/cell SD was determined (GI 4.85 +/- 0.82, GII 5.94 +/- 1.42, GIII 8.54 +/- 1.01 and GIV 8.72 +/- 1.42), among which statistically significant differences were found. For similar histologic grades the characteristic mean NORs/cell +/- SD showed no statistically sex and age related differences. In some cases the mean NORs/cell for the examined carcinoma did not match the characteristic mean NPRs/cell +/- SD for the respective histologic grade.
During the five-year period 56 children were treated in hospital due to respiratory infections caused by adenovirus. Clinical, laboratory and radiographic signs of the illness are presented. The infections manifested as the upper respiratory tract infection in 3 patients (5.4%), obstructive bronchitis in 16 patients (28.6%), bronchopneumonia in 32 patients (57.1%) and bronchiectasis in 5 patients (8.9%). Three children were operated: bilobectomy was performed in two cases, and left-sided pulmonectomy in one case. Histologically, bronchiectasis was found in two cases and bronchiolitis obliterans in one case. In this work we tried to show the gravity, importance and consequences of the adenoviral infection of the respiratory tract in children.