Brain is the most advanced part of the nervous system. As an emerging neighborhood exploring the brain, the brain-computer interface (BCI) may completely influence people's current communication and lifestyle in the future. We propose an architecture for feature extraction and classification model in brain-computer interface (BCI). Three features of EEG signal are extracted and combined in an attempt to describe the EEG signal more comprehensively including Wavelet packet decomposition, Information entropy and Co-space pattern (CSP). We construct the C-LSTM model combining the Convolutional Neural Networks (CNN) and the Long Short-Term Memory (LSTM) to perform the classification. Comparison was made with traditional approaches, and results show the method has a better performance for classification of motor imagery.
A 800G integrated silicon-photonic transmitter is presented, including a 16-channel photonic integrated chip (PIC) and two electrical chiplets (EICs) that are realized based on an arrayed travelling wave dual-drive Mach-Zehnder modulator (MZM) and two 8-channel CMOS drivers. The proposed multi-channel PIC is fabricated on a high-resistance silicon-on-insulator (SOI) wafer with a 220 nm thick silicon layer and a $\mathbf{2}\ \boldsymbol{\mu} \mathbf{m}$ thick buried oxide (BOX) using the foundry-ready CMOS process, while the drivers are implemented in a standard $\mathbf{65}\mathbf{nm}$ CMOS process. The driver employs a combination of distributed architecture, 2-tap feedforward equalization (FFE) and push-pull output stage, experimentally exhibiting an averaged bandwidth higher than 28.5GHz and a differential swing of 4.0Vpp on $\mathbf{50}\mathbf{\Omega}$ load, respectively. The 50Gb/s electrical eye-diagram is measured with 1.41ps rms-jitter, while the optical extinction ratio (ER) exceeds 3.0dB with 5.35pJ/bit power efficiency.
A hybrid integrated 16-channel silicon transmitter based on co-designed photonic integrated circuits (PICs) and electrical chiplets is demonstrated. The driver in the 65 nm CMOS process employs the combination of a distributed architecture, two-tap feedforward equalization (FFE), and a push–pull output stage, exhibiting an estimated differential output swing of 4.0 V pp . The rms jitter of 2.0 ps is achieved at 50 Gb/s under nonreturn-to-zero on–off keying (NRZ-OOK) modulation. The PICs are fabricated on a standard silicon-on-insulator platform and consist of 16 parallel silicon dual-drive Mach–Zehnder modulators on a single chip. The chip-on-board co-packaged Si transmitter is constituted by the multichannel chiplets without any off-chip bias control, which significantly simplifies the system complexity. Experimentally, the open and clear optical eye diagrams of selected channels up to 50 Gb/s OOK with extinction ratios exceeding 3 dB are obtained without any digital signal processing. The power consumption of the Si transmitter with a high integration density featuring a throughput up to 800 Gb/s is only 5.35 pJ/bit, indicating a great potential for massively parallel terabit-scale optical interconnects for future hyperscale data centers and high-performance computing systems.
Gallaecimonas pentaromativorans has been previously reported to be capable of degrading crude oil and diesel oil. G. pentaromativorans strain YA_1 was isolated from the southwest Indian Ocean and can degrade crude oil. This study reports the draft genome sequence of G. pentaromativorans, which can provide insights into the mechanisms of microbial oil biodegradation.
Self-injection locking has emerged as a crucial technique for coherent optical sources, spanning from narrow linewidth lasers to the generation of localized microcombs. This technique involves key components, namely a laser diode and a high-quality cavity that induces narrow-band reflection back into the laser diode. However, in prior studies, the reflection mainly relied on the random intracavity Rayleigh backscattering, rendering it unpredictable and unsuitable for large-scale production and wide-band operation. In this work, we present a simple approach to achieve reliable intracavity reflection for self-injection locking to address this challenge by introducing a Sagnac loop into the cavity. This method guarantees robust reflection for every resonance within a wide operational band without compromising the quality factor or adding complexity to the fabrication process. As a proof of concept, we showcase the robust generation of narrow linewidth lasers and localized microcombs locked to different resonances within a normal-dispersion microcavity. Furthermore, the existence and generation of localized patterns in a normal-dispersion cavity with broadband forward–backward field coupling is first proved, as far as we know, both in simulation and in experiment. Our research offers a transformative approach to self-injection locking and holds great potential for large-scale production.
Macrocycles show high activity for the electrochemical reduction of oxygen in alkaline media. However, even macrocycles with the same metal centers and MN4 active site can vary significantly in activity and selectivity, and to this date, a quantitative insight into the cause of these staggering differences has not been unambiguously reached. These macrocycles form a fundamental platform, similarly to platinum alloys for metal ORR catalyst, to unravel fundamental properties of FeNx catalysts. In this manuscript, we present a systematic study of several macrocycles, with varying active site motif and ligands, using electrochemical techniques, operando spectroscopy, and density functional theory (DFT) simulations. Our study demonstrates the existence of two families of Fe macrocycles for oxygen reduction in alkaline electrolytes: (i) weak *OH binding macrocycles with one peak in the voltammogram and high peroxide selectivity and (ii) macrocycles with close to optimal *OH binding, which exhibit two voltametric peaks and almost no peroxide production. Here, we also propose three mechanisms that would explain our experimental findings. Understanding what differentiates these two families could shed light on how to optimize the activity of pyrolyzed FeNx catalysts.
Abstract Background and Aims Proteinuria has been routinely screened in hospitalized patients at admission, but the changes in urinary protein during hospitalization is usually neglected. The epidemiology and clinical implication of new-onset proteinuria during hospitalization remains unclear. We aim to examine the associations between new-onset proteinuria during hospitalization with all-cause mortality, cardiovascular mortality, and composite kidney outcomes after discharge. Method We conducted a multicenter cohort of hospitalized adults without proteinuria at admission and with at least one repeated urinary protein test before discharge from the China Renal Data System. New-onset proteinuria was defined as a change in the urine dipstick protein test from negative to 1+ or more during hospitalization. The primary outcome was all-cause mortality after discharge. Secondary outcomes included cardiovascular mortality and composite kidney outcomes of sustained new-onset eGFR<60 ml/min/1.73 m2, >40% decline in eGFR, maintain dialysis, kidney transplant, or end stage renal disease. The associations between new-onset proteinuria and study outcomes were assessed by Cox proportional hazard models. Results Among 219,669 inpatients with mean age of 54 years, new-onset proteinuria occurred in 7.3% of the study population during hospitalization. After a mean follow-up of 4.9 years, patients with new-onset proteinuria during hospitalization was significantly associated with increased risk of all-cause mortality (hazard ratio [HR] 1.16; 95% confidence interval [CI], 1.07-1.25), cardiovascular deaths (HR 1.25; 95% CI, 1.07-1.46), and adverse kidney outcomes (HR 1.51; 95% CI, 1.14-2.01), compared to those without proteinuria. These associations were independent of the occurrence of AKI and remained consistent across subgroups and multiple sensitivity analyses, regardless of the severity and recovery status of new-onset proteinuria. Conclusion The presence of new-onset proteinuria during hospitalization demonstrated significant prognostic value and should be carefully monitored to improve patient care.
Optical chaos is vital for various applications such as private communication, encryption, anti-interference sensing, and reinforcement learning. Chaotic microcombs have emerged as promising sources for generating massive optical chaos. However, their inter-channel correlation behavior remains elusive, limiting their potential for on-chip parallel chaotic systems with high throughput. In this study, we present massively parallel chaos based on chaotic microcombs and high-nonlinearity AlGaAsOI platforms. We demonstrate the feasibility of generating parallel chaotic signals with inter-channel correlation <0.04 and a high random number generation rate of 3.84 Tbps. We further show the application of our approach by demonstrating a 15-channel integrated random bit generator with a 20 Gbps channel rate using silicon photonic chips. Additionally, we achieved a scalable decision-making accelerator for up to 256-armed bandit problems. Our work opens new possibilities for chaos-based information processing systems using integrated photonics, and potentially can revolutionize the current architecture of communication, sensing and computations.
A novel method used to design wideband balanced bandpass filter (BPF) is validated through a dual-mode balanced BPF based on semicircular patch resonator. In order to arrange the differential-mode (DM) passband, TM11 and TM31 modes are adopted. Approaches are employed to amend the disparity of the modes' resonant frequencies. For instance, two rows of vias are introduced to perturbed the electric field distribution of TM11 mode, which can shift the resonant frequency of TM11 mode to that of TM31 mode; two small patches are located at the balanced ports to decrease the resonant frequencies of TM11 and TM31 mode. Subsequently, for the purpose of common-mode (CM) suppression, cascaded defected ground structures (DGSs) are etched in the ground plane under the differential transmission line. The wideband balanced BPF is fabricated and measured. The results agree with each other very well, which validate the feasibility of the proposed design concept.
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