Guiming Zhang

Hubei University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Lijiang Sun

Qingdao University

Yao Zhu

Beijing Jishuitan Hospital

Dahai Dong

Affiliated Hospital of Qingdao University

Yu Yao

Affiliated Hospital of Qingdao University

Wen Liu

Karolinska Institutet

Fengju Guan

Affiliated Hospital of Qingdao University

Dingwei Ye

Fudan University Shanghai Cancer Center

Qiaoguo Wu

Hefei University of Technology

Guohai Shi

Fudan University Shanghai Cancer Center

Lei Luo

Qingdao University

Cooperative Institutions

Qingdao University

Affiliated Hospital of Qingdao University

Fudan University

Chinese Academy of Sciences

Fudan University Shanghai Cancer Center

Sun Yat-sen University

Shanghai Medical College of Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Southern Medical University

Shanghai Jiao Tong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Preparing long probes by an asymmetric polymerase chain reaction-based approach for multiplex ligation-dependent probe amplification

Analytical Biochemistry (2015)

Xingyuan Ling Guiming Zhang Guang Pan Hai Long Yinghui Cheng

Multiplex

10.1016/j.ab.2015.03.031

Cite

Citations (3)

PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma

Acta Pharmacologica Sinica (2022)

Liu Hon Guiming Zhang Sisi Huang Wenhui Shi Lin-Xuan Ye

Temsirolimus

10.1038/s41401-022-00862-1

Cite

Citations (7)

Association of ABO Blood Types and Clinicopathological Features of Prostate Cancer

Disease Markers (2017)

Fangming Wang Yan Zhang Guiming Zhang Yanan Liu Lijiang Sun

Purpose . To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC). Methods . A total of 237 pathologically diagnosed PC patients were enrolled. All patients were classified as low–middle or high-risk group. The correlation of ABO blood types with high-risk PC was determined by univariate and multivariate regression analysis. Results . Data indicated 144 (85.7%) patients were stratified as high risk in the non-O group, while 50 (72.5%) patients in the O group (p=0.025). However, there was no significant difference regarding PSA, Gleason score, stage, or metastasis between O and non-O group (p>0.05). Univariate logistic regression analyses revealed PSA, Gleason score, and blood type non-O were all correlated with high-risk PC (OR = 1.139, p<0.001; OR = 9.465, p<0.001; OR = 2.280, p=0.018, resp.). In the stepwise multivariate regression analysis, the association between blood type non-O and high-risk PC remained significant (OR = 33.066, 95% CI 2.391–457.323, and p=0.009) after adjusting for confounding factors as well as PSA and Gleason score. Conclusion . The present study firstly demonstrated that non-O blood type was at higher risk of aggressive PC compared with O type, suggesting that PC patients with non-O blood type should receive more attention in clinical practice.

10.1155/2017/9237481

Cite

Citations (9)

Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis

Disease Markers (2019)

Wen Liu Lijiang Sun Fengju Guan Fangming Wang Guiming Zhang

This study was performed to identify the prognostic impact of lymphovascular invasion (LVI) in patients with upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). A systematic search in PubMed, Embase, and the Cochrane Library was performed to identify relevant studies. The outcomes of interest, including progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS), were extracted, and the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used for effect size estimation. Subgroup, metaregression, and sensitivity analyses were performed to explore potential origins of heterogeneity. Publication bias was estimated by Egger’s linear regression and funnel plot. Our meta-analysis included a total of 27 studies involving 17,453 patients. The pooled HRs were statistically significant for PFS (HR=1.73, 95%CI=1.41–2.11), CSS (HR=1.87, 95%CI=1.54–2.27), and OS (HR=1.56, 95%CI=1.29–1.87), with high heterogeneity (I2=77.8%, 70.3%, and 59.2%, respectively). Four studies explored the prognostic value of LVI in patients with advanced tumor stages (T3–T4). The fixed effects model (I2=33.9%) showed that the pooled HR was 1.64 (95%CI=1.35–1.99) for CSS. Egger’s plots showed no significant publication bias (PFS: P=0.443, CSS: P=0.096, and OS: P=0.894). Our meta-analysis demonstrated that LVI is a poor prognostic factor for UTUC and is strongly associated with disease recurrence, cancer-specific mortality, and overall mortality.

Lymphovascular invasion

10.1155/2019/7386140

Cite

Citations (19)

Nutritional screening is strongly associated with overall survival in patients treated with targeted agents for metastatic renal cell carcinoma

Journal of Cachexia Sarcopenia and Muscle (2015)

Weijie Gu Guiming Zhang Lijiang Sun Qi Ma Yue Cheng

Concordance

10.1002/jcsm.12025

Cite

Citations (71)

Author response for "Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence"

Le Yu Dan Zhou Guiming Zhang Zhonglu Ren Xin Luo

BAP1

Senescence

10.1002/1878-0261.13128/v2/response1

Cite

Citations (1)

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment

Cancer Management and Research (2023)

Tian Liu Shangcong Han Yu Yao Guiming Zhang

Abstract: In recent years, the abnormal glucose metabolism of tumor cells has attracted increasing attention. Abnormal glucose metabolism is closely related to the occurrence and development of tumors. Monocarboxylate transporters (MCTs) transport the sugar metabolites lactic acid and pyruvate, which affect glucose metabolism and tumor progression in a variety of ways. Thus, research has recently focused on MCTs and their potential functions in cancer. The MCT superfamily consists of 14 members. MCT1 and MCT4 play a crucial role in the maintenance of intracellular pH in tumor cells by transporting monocarboxylic acids (such as lactate, pyruvate and butyrate). MCT1 and MCT4 are highly expressed in a variety of tumor cells and are involved the proliferation, invasion and migration of tumor cells, which are closely related to the prognosis of cancer. Because of their important functions in tumor cells, MCT1 and MCT4 have become potential targets for cancer treatment. In this review, we focus on the structure, function and regulation of MCT1 and MCT4 and discuss the developed inhibitors of MCT1 and MCT4 to provide more comprehensive information that might aid in the development of strategies targeting MCTs in cancer. Keywords: monocarboxylate transporter, tumor, tumor microenvironment, function, regulation

Monocarboxylate transporter

Tumor progression

10.2147/cmar.s421771

Cite

Citations (12)

High expression of F2RL3 correlates with aggressive features and poor survival in clear cell renal cell carcinoma

Journal of Cancer (2018)

Dalong Cao Yuanyuan Qu Xuan Zhang Fujiang Xu Shuxian Zhou

Background: Specific lifestyle factors including tobacco-exposure are vital etiologic factors for renal cell carcinoma (RCC), F2R Like Thrombin/Trypsin Receptor 3 (F2RL3) is associated with smoking but it is unknown whether its expression translate into poor survival of clear cell RCC (ccRCC). In the current study, the expression profiling and prognostic value of F2RL3 in Chinese patients with ccRCC were investigated. Methods: Using Quantitative PCR analysis and immunohistochemistry, the relative expression levels of F2RL3 in 367 paired ccRCC and adjacent normal tissues were calculated. Cox regression analysis was used to identify independent prognostic factors and Kaplan-Meier analysis and a log-rank test were employed to evaluate the prognostic value of F2RL3. Results: We observed that high expression of F2RL3 mRNA and protein were strongly correlated with shorten progression-free survival (PFS) of ccRCC with hazard ratios (HR; 95% confidence interval (CI)) of 2.060 (1.410-3.009) and 1.657 (1.193-2.300), respectively, as well as with poor overall survival (OS) with HRs (95%CI) of 2.826 (1.713-4.662) and 1.712 (1.140-2.569), respectively. After adjustment for confounding factors including smoking status, elevated HRs (95%CI) of 2.113 (1.445-3.089) and 1.692 (1.218-2.352) were presented for PFS, respectively, and 2.936 (1.777-4.851) and 1.811 (1.203-2.725) were present for OS, respectively. Meanwhile, increased F2RL3 mRNA and protein level were reported to significantly associate with smoking-exposure and well-known prognostic factors (higher TNM stage and ISUP grade). Conclusion: These findings suggested that F2RL3 mRNA and protein level in ccRCC is a robust predictor of poorly prognostic phenotype. Exploring the causal relevance of F2RL3 in ccRCC development further warrants in the future study.

10.7150/jca.23923

Cite

Citations (2)

Pretreatment Neutrophil-to-Lymphocyte Ratio

Medicine (2015)

Guiming Zhang Yao Zhu Xiaocheng Ma Xiaojian Qin Fangning Wan

The pretreatment neutrophil-to-lymphocyte ratio (NLR) is reportedly associated with the clinical outcomes of many cancers. However, it has not been widely investigated whether the pretreatment NLR is associated with the pathological characteristics of prostate cancer (PCa) and biochemical recurrence in PCa patients receiving radical prostatectomy (RP). In this cohort study, a total of 1688 PCa patients who had undergone RP were analyzed retrospectively, and a subset of 237 of these patients were evaluated to determine the relationship between pretreatment NLR and biochemical recurrence. Patients were divided into a high-NLR group (NLR ≥2.36) and a low-NLR group (NLR < 2.36) according to the pretreatment NLR. The association between the pretreatment NLR and pathological stage and lymph node involvement was evaluated using logistic regression analysis. Time of biochemical recurrence was determined using the Kaplan–Meier method. Cox's proportional hazard regression model was used to compare the time of biochemical recurrence between the groups. As compared with patients in the low-NLR group, those in the high-NLR group had an increased risk of pT3–4 disease (odds ratio (OR), 1.883; 95% confidence interval (CI), 1.419–2.500; P < 0.001), and a 1.7-fold increased risk of lymph node involvement (OR, 1.685; 95% CI, 1.101–2.579; P = 0.016). For the subset of 237 patients, those with a high NLR showed a significantly shorter median biochemical recurrence-free survival time (51.9 months) than those with a low NLR (76.5 months; log-rank test, P = 0.019). However, multivariate analysis indicated that the NLR was not an independent predictor of biochemical recurrence (hazard ratio, 1.388; 95% CI, 0.909–2.118; P = 0.129). Our findings suggest that the pretreatment NLR may be associated with pathological stage and lymph node involvement in PCa patients receiving RP, and that PCa patients with a high NLR may have a higher rate of biochemical recurrence following RP than those with a low NLR.

Biochemical recurrence

10.1097/md.0000000000001473

Cite

Citations (32)

Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness

Cytokine (2016)

Qiang Zhang Lijiang Sun Zhi‐gang Yang Guiming Zhang Ri-cha Huo

10.1016/j.cyto.2016.06.019

Cite

Citations (27)