A water environment security assessing system is constructed to respect the water environment security situation on pollution source, water quality, and ecology along Luan River to Tianjin Diversion Project. The model for assessment is proposed based on multi-hierarchy fuzzy theory. The corresponding assessment indexes, quantitative standards and weight functions are established. The system and method are applied to assess the water environment security status of Luan River-Tianjin Diversion Project. The result shows that the assessment system can reflect objective current status of water environment security. Therefore, it can provide technology support for securing water quality of Luan River-Tianjin Water diversion project.

Water diversion

River pollution

Water security

10.1109/icbbe.2010.5515083

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Citations (1)

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

Cell & Bioscience (2017)

Jie Huang Song Han Qi Sun Yipeng Zhao Junchen Liu

Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1.3 channel blockers are demonstrated potential therapeutic effects on MS patients and EAE models, maybe via reducing activation of T cells. However, it remains to be explored whether Kv1.3 channel blockers maintain integrity of BBB in MS model. In this study, ImKTx88, a highly selective Kv1.3 channel blocker, was used to determine the role of Kv1.3 channel in the pathogenesis of EAE, particularly in the maintenance of BBB. ImKTx88 ameliorated pathological severity in the EAE rats, and reduced extravasation into CNS. ImKTx88 also ameliorated the severity of loss or redistribution of tight junction proteins, and inhibited over-expression of ICAM-1 and VCAM-1 in the brain from EAE rats. Furthermore ImKTx88 protection was associated with activation of Ang-1/Tie-2 axis, and might be due to decreased IL-17 production. ImKTx88 may be a novel therapeutic agent for MS treatment by stabilizing the BBB.

Extravasation

Pathogenesis

Encephalomyelitis

Channel blocker

Infiltration (HVAC)

10.1186/s13578-017-0158-2

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Citations (25)

Coxsackievirus A16 infection triggers apoptosis in RD cells by inducing ER stress

Biochemical and Biophysical Research Communications (2013)

Guoguo Zhu Yingcheng Zheng Lianglu Zhang Yingying Shi Wenhua Li

Pathogenesis

Chemical chaperone

10.1016/j.bbrc.2013.10.142

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Citations (21)

Human Pirh2 is A Novel Inhibitor of Prototype Foamy Virus Replication

Viruses (2015)

Lanlan Dong Qingqing Cheng Zhihao Wang Peipei Yuan Zhi Li

Prototype foamy virus (PFV) is a member of the unconventional and nonpathogenic retroviruses. PFV causes lifelong chronic infections, which are partially attributable to a number of host cell factors that restrict viral replication. Herein, we identified human p53-induced RING-H2 protein (Pirh2) as a novel inhibitor of prototype foamy virus. Overexpression of Pirh2 decreased the replication of PFV, whereas knockdown of Pirh2 with specific siRNA increased PFV replication. Dual-luciferase assays and coimmunoprecipitation demonstrated that Pirh2 negatively influences the Tas-dependent transcriptional activation of the PFV long terminal repeat (LTR) and internal promoter (IP) by interacting with the transactivator Tas and down-regulating its expression. In addition, the viral inhibitory function of Pirh2 is N-terminal and RING domain dependent. Together, these results indicated that Pirh2 suppresses PFV replication by negatively impacting its transactivator Tas and the transcription of two viral promoters, which may contribute to the latency of PFV infection.

Transcription

10.3390/v7041668

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Citations (21)

[The research progress of foamy virus Bet protein].

PubMed (2012)

Yuan Gao Yan Sun Zhi Li Qingmei Liu Wanhong Liu

Foamy virus can establish lifelong persistent infection in mammal hosts without inducing diseases. Such special characteristic stimulates the interests of researchers. As reported, the accessory protein Bet of foamy virus could regulate the gene expression and infection cycle of foamy virus and take part in the generation of chronic viral infection. And also, Bet might prevent the host cellular defense factor APO-BEC3 from interfering the replication of virus and play a role in maintaining viral persistent infection. In order to elucidate the roles of Bet in the foamy virus replication and infection, this review summarized the research progress of Bet protein reported in recent years.

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Development of Viral Vectors for Gene Therapy for Chronic Pain

Pain Research and Treatment (2011)

Yu Huang Xin Liu Lanlan Dong Zhongchun Liu Xiaohua He

Chronic pain is a major health concern that affects millions of people. There are no adequate long-term therapies for chronic pain sufferers, leading to significant cost for both society and the individual. The most commonly used therapy for chronic pain is the application of opioid analgesics and nonsteroidal anti-inflammatory drugs, but these drugs can lead to addiction and may cause side effects. Further studies of the mechanisms of chronic pain have opened the way for development of new treatment strategies, one of which is gene therapy. The key to gene therapy is selecting safe and highly efficient gene delivery systems that can deliver therapeutic genes to overexpress or suppress relevant targets in specific cell types. Here we review several promising viral vectors that could be applied in gene transfer for the treatment of chronic pain and further discuss the possible mechanisms of genes of interest that could be delivered with viral vectors for the treatment of chronic pain.

10.1155/2011/968218

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Citations (35)

miR-27a suppresses EV71 replication by directly targeting EGFR

Virus Genes (2014)

Lianglu Zhang Xiong Chen Yingying Shi Bingfei Zhou Chen Du

Enterovirus 71

10.1007/s11262-014-1114-4

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Citations (29)

A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury

Neuroscience Letters (2008)