Tsung‐Han Hsieh

National Kaohsiung University of Science and Technology

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Yun‐Ru Liu

Taipei Medical University

Yu‐Chen Lin

Taipei Medical University

Chun‐Han Chen

Taipei Medical University

Hao‐Ching Wang

Taipei Medical University

Jing‐Ping Liou

Taipei Medical University

Yan-Ni Lo

Yu‐Ching Lee

Taipei Medical University

Cheng‐Ying Chu

Taipei Medical University

Chun A. Changou

Taipei Medical University

Yun Yen

Taipei Medical University

Cooperative Institutions

National Yang Ming Chiao Tung University

National Taiwan University

National Cheng Kung University

Louisiana State University Health Sciences Center Shreveport

National Kaohsiung University of Science and Technology

Academia Sinica

Taipei Medical University

National Taiwan University Hospital

Louisiana State University Health Sciences Center New Orleans

Louisiana State University

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DOA Estimation of Quasi-Stationary Signals With Less Sensors Than Sources and Unknown Spatial Noise Covariance: A Khatri–Rao Subspace Approach

IEEE Transactions on Signal Processing (2009)

Wing‐Kin Ma Tsung‐Han Hsieh Chong‐Yung Chi

In real-world applications such as those for speech and audio, there are signals that are nonstationary but can be modeled as being stationary within local time frames. Such signals are generally called quasi-stationary or locally stationary signals. This paper considers the problem of direction-of-arrival (DOA) estimation of quasi-stationary signals. Specifically, in our problem formulation we assume: i) sensor array of uniform linear structure; ii) mutually uncorrelated wide-sense quasi-stationary source signals; and iii) wide-sense stationary noise process with unknown, possibly nonwhite, spatial covariance. Under the assumptions above and by judiciously examining the structures of local second-order statistics (SOSs), we develop a Khatri-Rao (KR) subspace approach that has two notable advantages. First, through an identifiability analysis, it is proven that this KR subspace approach can operate even when the number of sensors is about half of the number of sources. The idea behind is to make use of a ¿virtual¿ array structure provided inherently in the local SOS model, of which the degree of freedom is about twice of that of the physical array. Second, the KR formulation naturally provides a simple yet effective way of eliminating the unknown spatial noise covariance from the signal SOSs. Extensive simulation results are provided to demonstrate the effectiveness of the KR subspace approach under various situations.

Identifiability

Signal subspace

Stationary process

Direction of arrival

10.1109/tsp.2009.2034935

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Citations (286)

Rhabdomyolysis caused by the moderate CYP3A4 inhibitor fluconazole in a patient on stable atorvastatin therapy: a case report and literature review

Journal of Clinical Pharmacy and Therapeutics (2016)

Shu Hwa Hsiao Hui Ju Chang Tsung‐Han Hsieh Shu Min Kao P.-Y. Yeh

Rhabdomyolysis is a severe potential adverse drug reaction of statin therapy. We report a case of rhabdomyolysis due to drug-drug interaction (DDI) between atorvastatin and fluconazole and review the literature.A 70-year-old woman received atorvastatin for hyperlipidaemia without any problem for 4 years. When intravenous fluconazole was added for treating a fungal infection, rhabdomyolysis developed 2 weeks later. Removal of atorvastatin led to the resolution of her rhabdomyolysis.Our case demonstrates that in some subjects even a moderate CYP3A4 inhibitor such as fluconazole may lead to rhabdomyolysis in subjects receiving a statin.

Adverse drug reaction

10.1111/jcpt.12425

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Citations (18)

The mechanical properties and delamination of carbon fiber-reinforced polymer laminates modified with carbon aerogel

Journal of Materials Science (2016)

Tsung‐Han Hsieh Yau‐Shian Huang

Delamination

Carbon fibers

10.1007/s10853-016-0646-5

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Citations (30)

A novel self-biased low noise amplifier with current-reused technique for X band applications

Asia-Pacific Microwave Conference (2009)

Chin‐Lung Yang Tsung‐Han Hsieh Yi‐Chyun Chiang

A low-noise amplifier (LNA) employing novel self-biased shunt-feedback mechanism for X band applications is presented. The shunt-shunt feedback impedance is not only used to eliminate the use of gate-biased voltage, but also neutralize the miller capacitor of the input transistor. With combining current-reused technique into the amplifier, it is benefit to boost power gain and maintain low power consumption. A source-degeneration inductor is also introduced at the input transistor to ensure good input matching and stability across the required bandwidth. A prototype was fabricated in 0.18-¿m CMOS process to demonstrate the proposed LNA architecture. The measurements show that a maximum power gain of 10 dB, a minimum noise figure (NF) of 4.5 dB, -6 dBm input-referred third-order intercept point (IIP ₃ ), and drawing 7.6 mA from a 1.8-V supply.

Wideband

Power gain

10.1109/apmc.2009.5384321

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Citations (4)

Acquisition of Surface EMG Using Flexible and Low-Profile Electrodes for Lower Extremity Neuroprosthetic Control

IEEE Transactions on Medical Robotics and Bionics (2021)

Seong Ho Yeon Tony Shu Hyungeun Song Tsung‐Han Hsieh Junqing Qiao

For persons with lower extremity (LE) amputation, acquisition of surface electromyography (sEMG) from within the prosthetic socket remains a significant challenge due to the dynamic loads experienced during the gait cycle. However, these signals are critical for both understanding the clinical effects of LE amputation and determining the desired control trajectories of active LE prostheses. Current solutions for collecting within-socket sEMG are generally (i) incompatible with a subject's prescribed prosthetic socket and liners, (ii) uncomfortable, and (iii) expensive. This study presents an alternative within-socket sEMG acquisition paradigm using a novel flexible and low-profile electrode. First, the practical performance of this Sub-Liner Interface for Prosthetics (SLIP) electrode is compared to that of commercial Ag/AgCl electrodes within a cohort of subjects without amputation. Then, the corresponding SLIP electrode sEMG acquisition paradigm is implemented in a single subject with unilateral transtibial amputation performing unconstrained movements and walking on level ground. Finally, a quantitative questionnaire characterizes subjective comfort for SLIP electrode and commercial Ag/AgCl electrode instrumentation setups. Quantitative analyses suggest comparable signal qualities between SLIP and Ag/AgCl electrodes while qualitative analyses suggest the feasibility of using the SLIP electrode for real-time sEMG data collection from load-bearing, ambulatory subjects with LE amputation.

10.1109/tmrb.2021.3098952

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Citations (15)

Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen–glucose deprivation condition

Pharmacological Reports (2023)

Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu

Schaffer collateral

Brain ischemia

LTP induction

10.1007/s43440-023-00525-w

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Citations (2)

Organic cation transporter 2 activation enhances sensitivity to oxaliplatin in human pancreatic ductal adenocarcinoma

Biomedicine & Pharmacotherapy (2022)

Ching‐Feng Chiu Ji Min Park Hsin‐Hua Chen Chen-Zou Mau Pai‐Sheng Chen

Oxaliplatin, a third-generation platinum derivative, has become one of the main chemotherapeutic treatments for esophagus, gastric and colorectal cancer; however, it is still unclear the potential effectiveness for pancreatic ductal adenocarcinoma (PDAC) with gemcitabine resistance. Here, we observed that PDAC tumors have low level of organic cation transporter 2 (OCT2, also known as SLC22A2) compared with non-tumor tissues and identified that OCT2 expression is positively correlated with oxaliplatin sensitivity in PDAC cells. Treatment of OCT2 inhibitors or knockdown of OCT2 expression significantly decreased the sensitivity to oxaliplatin in PANC-1 cells. In addition, bisulfite sequencing polymerase chain reaction analysis revealed that higher methylation frequency represses OCT2 expression in gemcitabine-resistant PANC-1 (PANC-1/GR) cells. Moreover, we found that treatment of DNA methyltransferase (DNMT) inhibitors, decitabine or 5-azacytidine recover OCT2 expression and oxaliplatin sensitivity in PANC-1/GR cells, and DNMT1 level has inverse correlation with OCT2 expression in PDAC cells and tumors. Our findings jointly suggest that OCT2 expression is a potential and predictive marker for evaluating oxaliplatin sensitivity and developing alternative treatments for PDAC patients with gemcitabine resistance.

Decitabine

10.1016/j.biopha.2022.113520

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Citations (5)

Use of computer animation for displaying the mode shapes of a three-dimensional framework

Jia‐Jang Wu Fang-Yu Chen Tsung‐Han Hsieh

This paper presents a method to integrate the free vibration theory and the computer graphical technique for displaying the mode shapes of a three-dimensional framework, so that one may see the real-time animation of the structural mode shapes on the computer screen. Because the graphical parameters, such as view angle, position of the projection plane, ..., etc., cannot be changed arbitrarily (at any time) in the existing post-processing procedures when the animation of the structural mode shapes is in progressing, it is difficult for one to observe the detail of the three-dimensional mode shapes from the computer screen. To solve this problem, some computer subroutines and a graphical user interface are developed for providing an interactive way between the users and the computer. Using the last technique, one may see the real-time animation of structural mode shapes with arbitrary graphical parameters at any time. Furthermore, because the vibration amplitudes and frequencies for the mode shapes are adjustable (enlarged or reduced) in the developed computer programs, one may also see the detail of any part of any mode shape of the structure from the computer screen no matter whether the vibration amplitudes and frequencies are very small or very large.

Mode (computer interface)

Graphical user interface

Subroutine

Position (finance)

10.1109/csit.2013.6588774

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Citations (1)

體表電近場放射之動態量測; Dynamic Tomography Measurement of Skin Electric Near Field Emitting

謝宗翰 Tsung‐Han Hsieh

Source

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Mechanical Property of Multiwall Carbon Nanotube Reinforced Polymer Composites

Polymers and Polymer Composites (2018)

Chao‐Kai Yang Yu-Roung Lee Tsung‐Han Hsieh Tao‐Hsing Chen Tsung‐Chieh Cheng

This study investigates the multiwalled carbon nanotube as potential mechanical reinforcement in epoxy polymer. It is found that, by adding various concentrations of nanotube, both flow stress and fracture strain increased. Furthermore, the presences of the multiwalled carbon nanotubes are found to nucleate crystallization in the epoxy. This crystal growth is thought to enhance the strength of composite. The fracture surface analysis of the composite reinforced by carbon nanotube is used the scanning electron microscopy.

10.1177/096739111802600112

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Citations (28)