Liping Shen

Beijing Radiation Center

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Qi Wang

Qingdao University

Wenrui Jin

Shandong University

Junyan He

University of South China

Zhidong Wang

University of South China

Xiaoli Zhang

Xuzhou Medical College

Lingshuang Liu

Shanghai University of Traditional Chinese Medicine

Chuxian Lin

Beijing Radiation Center

Zhenhua Qi

Beijing Radiation Center

Xiaofei Zheng

Shanghai Institute of Hematology

Guizheng Zou

Shandong University

Cooperative Institutions

Wenzhou Medical University

Sun Yat-sen University

Memorial Sloan Kettering Cancer Center

Chinese Academy of Sciences

Shandong University

Inserm

Soochow University

Chinese Academy of Medical Sciences & Peking Union Medical College

Dana-Farber Cancer Institute

University of Southern California

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Metabolomics unveils the mechanism of Bufei Huayu decoction in combination with cisplatin against non-small cell lung cancer (NSCLC)

Heliyon (2023)

Feng Yuan Ying Jiang Ying Zhou Zhanhua Li Qi-qian Yang

IntroductionBufei Huayu Decoction (BFHY) is a clinical prescription with reported efficacy in enhancing the therapeutic outcomes of chemotherapeutic agents for non-small cell lung cancer (NSCLC). However, the underlying metabolic mechanism of BFHY's action remains unexplored.ObjectiveThe objective of this study is to investigate the global metabolic effects of cisplatin and cisplatin plus BFHY on NSCLC.MethodsThree groups (NSCLC, cisplatin, and cisplatin + BFHY) underwent a serum metabolomics procedure based on UHPLC-QE-MS. Then, a pathway analysis was carried out using MetaboAnalyst 3.0 to elucidate the therapeutic action routes of cisplatin and cisplatin plus BFHY in NSCLC.ResultsIn the subcutaneous NSCLC model, both cisplatin and cisplatin + BFHY reduced the tumor volume and caused cell death. In comparison to cisplatin alone, cisplatin + BFHY showed a stronger tumor-suppressing impact. Furthermore, the same 16 metabolic signaling pathways were shared by the cisplatin and cisplatin + BFHY treatments. These typical metabolites are mainly involved in amino acid metabolism, lipid mobilization, nucleic acid metabolism and carbohydrate metabolites.ConclusionsPotential biomarkers and metabolic networks of cisplatin and cisplatin + BFHY's anti-tumor actions are revealed in our investigation.

10.1016/j.heliyon.2023.e19155

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Citations (0)

Lnc00892 competes with c-Jun to block NCL transcription, reducing the stability of RhoA/RhoC mRNA and impairing bladder cancer invasion

Oncogene (2021)

Shuwei Ren Ning Zhang Liping Shen Yongyong Lu Yi-Xin Chang

Nucleolin

RhoC

10.1038/s41388-021-02033-8

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Citations (12)

Chemiluminescence based on UV-assisted persulfate activation for sensitive detection of triphenyl phosphate

The Science of The Total Environment (2022)

Liping Shen Xiao‐Ying Huang Zhixiao Zhang Qiumeng Chen Xue Zou

Luminol

Persulfate

Triphenyl phosphate

Degradation

10.1016/j.scitotenv.2022.155617

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Citations (18)

Involvement of the oncogenic small nucleolar RNA SNORA24 in regulation of p53 stability in colorectal cancer

Cell Biology and Toxicology (2022)

Liping Shen Chuxian Lin Wenqing Lü Junyan He Qi Wang

Small nucleolar RNA

Microsatellite Instability

10.1007/s10565-022-09765-7

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Citations (5)

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA

Nucleic Acids Research (2017)

Liping Shen Qi Wang Ruixue Liu Zhongmin Chen Xueqing Zhang

DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. The current models of the mechanism of DSB repair are based on studies of DNA repair proteins. Long non-coding RNAs (lncRNAs) have recently emerged as new regulatory molecules, with diverse functions in biological processes. In the present study, we found that expression of the ionizing radiation-inducible lncRNA, lnc-RI, was correlate negatively with micronucleus frequencies in human peripheral blood lymphocytes. Knockdown of lnc-RI significantly increased spontaneous DSBs levels, which was confirmed to be associated with the decreased efficiency of homologous recombination (HR) repair of DSBs. The expression of RAD51, a key recombinase in the HR pathway, decreased sharply in lnc-RI-depressed cells. In a further investigation, we demonstrated that miR-193a-3p could bind with both lnc-RI and RAD51 mRNA and depressed the expression of lnc-RI and RAD51 mRNA. Lnc-RI acted as a competitive endogenous RNA (ceRNA) to stabilize RAD51 mRNA via competitive binding with miR-193a-3p and release of its inhibition of RAD51 expression. To our knowledge, this is the first study to demonstrate the role of lnc-RI in regulating HR repair of DSBs. The feedback loop established in the current study suggests that lnc-RI is critical for the maintenance of genomic stability.

10.1093/nar/gkx1224

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Citations (82)

Alterations in gene expression during sexual differentiation in androgen receptor knockout mice induced by environmental endocrine disruptors

International Journal of Molecular Medicine (2015)

Dehong Liu Liping Shen Yonglin Tao Ying Kuang Lei Cai

Following the publication of this article, the authors noticed the following error: In the Abstract, the full name of DBP should be dibutyl phthalate and not D binding protein. The same error was observed on the second page of the manuscript (second line on right column), where the full name of DBP should be dibutyl phthalate and not D binding protein. [the original article was published in the International Journal of Molecular Medicine 35: 399-404, 2015 DOI: 10.3892/ijmm.2014.2015].

Sexual Differentiation

Knockout mouse

Gene knockout

10.3892/ijmm.2015.2097

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Citations (1)

One‐Pot Synthesis of Dual‐Stabilizer‐Capped CdTe Nanocrystals with Efficient Near‐Infrared Photoluminescence and Electrochemiluminescence

European Journal of Inorganic Chemistry (2011)

Guodong Liang Liping Shen Xiaoli Zhang Guizheng Zou

Abstract CdTe nanocrystals (NCs) are promising near‐infrared (NIR) emitter candidates. A one‐pot synthetic strategy has been developed for high‐quality NIR‐emitting CdTe NCs with mercaptopropionic acid and sodium hexametaphosphate as dual stabilizers. The dual‐stabilizer‐capped CdTe NCs displayed efficient photoluminescence (PL) between the visible and near‐infrared region (533–778 nm) with a quantum yield of up to 47 %. XRD, XPS, and photoluminescence spectra were employed to characterize the structure and optical features of these samples. Moreover, the NIR‐emitting CdTe NCs also displayed strong band‐gap electrochemiluminescence in the NIR region, indicating that this strategy can be used to synthesize NCs with both efficient fluorescence and electrochemiluminescence emissions in the NIR region.

Electrochemiluminescence

Cadmium telluride photovoltaics

Quantum yield

Sodium hexametaphosphate

10.1002/ejic.201100403

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Citations (31)

Highly efficient sensor for triphenyl phosphate based on UV-induced chemiluminescence

Microchemical Journal (2022)

Xiao‐Ying Huang Liping Shen Huanhuan Zhu Huan Chen Zhengjun Gong

Triphenyl phosphate

10.1016/j.microc.2022.108327