Laura Sánchez

Canisius-Wilhelmina Ziekenhuis

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Paloma López‐Ortego

Hospital Universitario La Paz

Josep Vergés

Bioibérica (Spain)

María Carmen Bravo

Hospital Universitario La Paz

Adelina Pellicer

Hospital Universitario La Paz

Marta Herrero

Hospital Universitario Virgen del Rocío

Fernando Cabañas

Hospital Universitario Quirónsalud Madrid

Ethan Viles

Montana State University

Claudia Grimaldi

Telethon Institute Of Genetics And Medicine

Sergio Giménez

Hospital Universitario Doctor Peset

H. Martínez

Bioibérica (Spain)

Cooperative Institutions

Hospital Universitario La Paz

Istituti di Ricovero e Cura a Carattere Scientifico

Boston Children's Hospital

Inserm

Universidad Autónoma de Madrid

Hippocration General Hospital

Aristotle University of Thessaloniki

Universitat Autònoma de Barcelona

Instituto de Salud Carlos III

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

[Perioperative treatment of a pregnant woman with recent cerebral infarction secondary to noncompaction cardiomyopathy].

PubMed (2006)

Laura Sánchez R Pérez González E. Guasch Roberto Martín Reyes Fernando Rodríguez

Presentation (obstetrics)

Source

Cite

Citations (8)

OP0057 Effects of Chondroitin Sulfate on Brain Response to Painful Stimulation in Knee Osteoarthritis Patients

Annals of the Rheumatic Diseases (2014)

Jordi Monfort Jesús Pujol Oren Contreras‐Rodríguez Jone Llorente‐Onaindia Marina López‐Solà

Background

Knee osteoarthritis (OA) is a degenerative joint disease causing symptoms in 12% of people over the age of 65¹. One of the inherent problems with efficacy assessment of pain medication was the lack of objective pain measurements. In recent years functional MRI (fMRI) has emerged as a useful means to objectify brain response to painful stimulation².

Objectives

The aim of the present fMRI study was to objectively identify the effects of 4-month Condroitin Sulfate (CS) treatment on the brain response to pressure painful stimulation in patients with knee OA.

Methods

This is a phase IV, randomized, double-blind clinical trial in which patients received CS 800 mg/day (Condrosan®, Bioiberica) or placebo for a 4-month treatment course. 64 patients were randomized and 49 were evaluable (27 in placebo and 22 in CS). Patients were assessed at baseline and post-treatment. Two tests were conducted in each session by applying adjusted painful pressure on patella surface and on knee medial interline during acquisition of two 6-min fMRI sequences. The main outcome measurement was attenuation of the response evoked by knee painful stimulation in the pain-processing brain system.

Results

Patients receiving CS showed a tendency to report reduced subjective pain after treatment during patella pressure test (p=0.077) but no significant group by session interaction was demonstrated. fMRI of patella pain showed a larger activation reduction in CS group than in placebo in a posterior mesencephalon region including the periaqueductal gray (PAG). The entire PAG cluster (238voxels) with significant interaction showed a pre>post-treatment difference at p<0.05. In this paired analysis, CS group showed significant activation reduction in primary somatosensory cortex and extending to primary motor cortex and posterior supplementary motor area. Group by session interaction consistently revealed a tendency for this cortical change to be larger in the CS than in placebo (peak interaction x=2, y=-6, z=72; t=2.96, p=0.002 and 43 voxels-subthreshold- with p<0.01). No effects of CS were detected using the knee interline pressure test.

Conclusions

The study succeeded in primary objective as a significant effect was demonstrated showing attenuation of brain response to painful pressure in key regions of pain-processing network using patella test. Despite knee medial interline is one of the most tenders points in patients with knee osteoarthritis, the pain generated by pressing down the patella surface, is probably less complex, and may be more selectively related to sensitization processes in the bone and the junction between bone and cartilage³. The observed positive effect of CS is consistent with the known CS action on cartilage protection.

References

Dillon CF, Rasch EK, Gu Q, Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991–1994. J Rheumatol 33, 2271–9. Schweinhardt P, Lee M, Tracey I. Imaging pain in subjects: is it meaningful? Curr Opin Neurol 19, 392-400. Felson DT. The sources of pain in knee osteoarthritis. Curr Opin Rheumatol 17, 624-8

Disclosure of Interest

None declared

DOI

10.1136/annrheumdis-2014-eular.4908

Cite

Citations (0)

El género y la sexualidad entre rejas: Del cuerpo en el imaginario de las mujeres privadas de su libertad en Córdoba

Laura Sánchez

espanolEste articulo se propone observar como se inscriben, a partir de ciertas modulaciones reglamentarias, los cuerpos de las mujeres apresadas enel sistema penal, explorando sobre los rastros de la administracion del castigo en las mujeres detenidas en Cordoba. La prision es un escenario extraordinario donde se producen intercambios e imposiciones simbolicas sobre los cuerpos y estos a su vez son producidos desde marcos normativos sobre el genero y la sexualidad. Apartir de la comprension del cuerpo como un intersticio entre ciertas lecturas criminologicas y feministas, recorremos las legislaciones y reglamentaciones de ejecucion penal para poder extraer de alli una lectura entrelineas. Luego, un recorrido por el encierro carcelario de las mujeres en Cordoba,a traves de las voces de informantes claves nos permiten suturar el confinamiento con cierto “orden social” que delimita el imaginario de “las mujeres”. EnglishThis article aims to observe how the bodies of women are inscribedin the penal system,from certain regulatory modulationsandexploring the traces of the administration of punishment in women detained in Cordoba.Prison is an extraordinary scenario where symbolic exchanges and impositions take place on bodies and these in turn are produced from normative frameworks on gender andsexuality. Fromthe understanding of the body as an interstice between certain criminological and feminist readings, we go through the laws and regulations of criminal execution so that we can extract an interfaith reading from it. Then, a tour of the women's prison in Cordoba through the voices of key informants allows us to suture confinement with a “social order” that delimits the imaginary of “women”.

Source

Cite

Citations (0)

Cartografía de la pandemia en las cárceles: La situación de los derechos humanos de las personas privadas de su libertad en Córdoba, Argentina / Mapping the pandemic in prisons. The human rights situation of people detained in prison in Córdoba, Argentina

Laura Sánchez Angélica Rossana Gauna

Pandemic

Source

Cite

Citations (0)

AN OVERVIEW OF PERITONEAL DIALYSIS MANAGEMENT IN NEWBORNS DURING A PERIOD OF 10 YEARS

Archives of Disease in Childhood (2008)

Laura Sánchez Marta Cabrera A M Sanchez-Torres Dolores Elorza J. M. Perez

Introduction The incidence of acute renal failure (ARF) in neonates ranges from 8 to 24%. Peritoneal dialysis (PD) is a replacement therapy used in the neonatal intensive care unit (NICU) in some cases of ARF. Objectives To assess indications, methodology and most important complications of PD in newborns. Materials and Methods Review of medical charts of 39 dialysed newborns, between 1997 and 2007 admitted to a NICU with cardiac surgery. Results 85% were neonates with cardiac diseases, 5% with inborn errors of metabolism, 10% with other aetiologies. Gestational age and weight ranged from 24 to 36.5 weeks and 700 to 2520 g. Dialysis catheter (Arrow 8F) was inserted at the bedside by the neonatology staff, without complications. Initial mean volume hourly amounts were 15 ml/kg of 1.5% glucose dialysate. Increases in volume, mean 19 ml/kg (10–38 ml/kg) and glucose concentration, mean 3.1% were used to get the objectives. Higher ultrafiltrate volume was 6 ml/kg per hour. Indications for PD in congenital heart diseases were: 67% severe oliguria, 16% anuria, 13% hypervolaemia and 6% others. PD was stated at 14 h after surgery bypass and mean duration was 4 days (0.5–23 days). Complications appeared in 20/34 and were: 50% obstruction, 23% fluid loss, 15% hyperglycaemia, 8% peritonitis and 4% others. Catheter replacement was needed in 15 patients. Conclusions PD for ARF in newborns is an easy bedside technique, short-term extrarrenal replacement therapy, with few complications. Special usefulness is seen in cardiac patients after bypass surgery.

Anuria

Oliguria

Renal replacement therapy

Neonatology

Source

Cite

Citations (0)

Pharmacological approach of knee osteoarthritis treatment in primary care in spain

Osteoarthritis and Cartilage (2017)

Marta Herrero Sergio Giménez J. Vergara Ethan Viles H. Martínez

Dyslipidemia

10.1016/j.joca.2017.02.351

Cite

Citations (1)

Pregnancy with severe influenza A (H1N1) related acute respiratory distress syndrome: Report of three cases from a rural critical care unit in India

Indian Journal of Critical Care Medicine (2015)

Harish Handyal Laura Sánchez Rajesh V. Babu Jyothisuchithra Mekala

Sir, Pregnant women are important medically susceptible subset of the population. Changes in immune function during pregnancy alter a pregnant womans susceptibility to and severity of certain infectious diseases. These alterations are particularly problematic because physicians may hesitate to provide prophylaxis or aggressive treatment to pregnant women because of concerns about effects on the fetus. Because of concerns about the severity of the disease during pregnancy, the Center for Disease Control and Prevention has implemented enhanced surveillance for infection and has placed them in a group that merits priority vaccine administration. Pregnant women were more likely to be hospitalized or admitted to Intensive Care Units (ICU) and were at higher risk of death compared to nonpregnant adults. In critically ill pregnant patients, spectrum of clinical features associated with H1N1 infection includes, rapidly progressive lower respiratory tract disease and acute respiratory distress syndrome (ARDS) with refractory hypoxemia and secondary bacterial infection, septic shock, and multiorgan failure. Increased mortality was seen in patients with ARDS following H1N1 influenza as compared to all other causes of ARDS in Indian settings.[1] We report three pregnant patients with bilateral pneumonia in severe ARDS, admitted in our ICU. Their nasopharyngeal and endotracheal swabs were positive for H1N1. In our experience, we noticed the wide variation in the course of events that the disease displayed during ICU stay [Table 1]. The first Case A Figure 1, the delay in termination of pregnancy and also the delay in starting the antiviral therapy made her more prone to fatal outcome. Whereas in Cases B Figure 2 and C Figure 3, early delivery combined with a lung-protective ventilation strategy provided significantly better fetal and maternal outcomes.[2] We also noticed that prone position ventilation[4] and low-dose methylprednisolone infusion[3,5] improved oxygenation and eventually outcomes in the survivors Figure 4. Table 1 Course of events during Intensive Care Unit stay Figure 1 Timeline of Case A Figure 2 Timeline of Case B Figure 3 Timeline of Case C Figure 4 As there are three patients in the study, we included all the X-rays in one figure (which includes, one at admission and one before discharge/death) Early treatment with antiviral medication is recommended for pregnant women with suspected novel H1N1 infection regardless of the gestational age.[6] Oseltamivir has been used quite extensively in pregnancy with good results, and of most benefit when administered within 48 h of symptom onset and may reduce the incidence of pneumonia in patients with seasonal influenza.[6] In a report of six maternal deaths with H1N1 pandemic influenza, none of these patients had received antiviral within 48 h of onset of symptoms.[7] In conclusion, our experience suggests that pregnant women are at high-risk of complications such as ARDS requiring mechanical ventilation from H1N1 influenza. We also suggest the following. Early termination of pregnancy may result in improvement in the mother's condition. The timing to terminate is a critical decision necessitating proper cooperation with an obstetrician. Antiviral drugs should be started empirically. To follow ARDS net ventilation protocol and prone position ventilation as necessary. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

10.4103/0972-5229.171416

Cite

Citations (4)

¿Lo sustantivo del derecho penal?

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

Natalia Monasterolo Laura Sánchez

This text attempts to assemble the micropolitics of the bond, from which the authors subscribe, with a critical look at penal dogmatics and its teaching in universities. It is from this microscopic, everyday and situated place that we write; and we do so in political terms, since they will find a deliberate, subjective and significant position between us (as subjects) and the word.

Position (finance)

Derecho

Source

Cite

Citations (0)

Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial

PLoS ONE (2020)

Irja Lutsar Corine Chazallon Ursula Trafojer Vincent Meiffredy de Cabre Cinzia Auriti

The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore and had variable inclusion/exclusion criteria and outcome measures. Moreover, antibiotic-resistant bacteria have become a major problem in many countries worldwide. We hypothesized that efficacy of meropenem as a broad-spectrum antibiotic is superior to standard of care regimens (SOC) in empiric treatment of LOS and aimed to compare meropenem to SOC in infants aged <90 days with LOS.NeoMero-1 was a randomized, open-label, phase III superiority trial conducted in 18 neonatal units in 6 countries. Infants with post-menstrual age (PMA) of ≤44 weeks with positive blood culture and one, or those with negative culture and at least with two predefined clinical and laboratory signs suggestive of LOS, or those with PMA >44 weeks meeting the Goldstein criteria of sepsis, were randomized in a 1:1 ratio to receive meropenem or one of the two SOC regimens (ampicillin+gentamicin or cefotaxime+gentamicin) chosen by each site prior to the start of the study for 8-14 days. The primary outcome was treatment success (survival, no modification of allocated therapy, resolution/improvement of clinical and laboratory markers, no need of additional antibiotics and presumed/confirmed eradication of pathogens) at test-of-cure visit (TOC) in full analysis set. Stool samples were tested at baseline and Day 28 for meropenem-resistant Gram-negative organisms (CRGNO). The primary analysis was performed in all randomised patients and in patients with culture confirmed LOS. Proportions of participants with successful outcome were compared by using a logistic regression model adjusted for the stratification factors. From September 3, 2012 to November 30th 2014, total of 136 patients (instead of planned 275) in each arm were randomized; 140 (52%) were culture positive. Successful outcome at TOC was achieved in 44/136 (32%) in the meropenem arm vs. 31/135 (23%) in the SOC arm (p = 0.087). The respective numbers in patients with positive cultures were 17/63 (27%) vs. 10/77 (13%) (p = 0.022). The main reason of failure was modification of allocated therapy. Treatment emergent adverse events occurred in 72% and serious adverse events in 17% of patients, the Day 28 mortality was 6%. Cumulative acquisition of CRGNO by Day 28 occurred in 4% of patients in the meropenem and 12% in the SOC arm (p = 0.052).Within this study population, we found no evidence that meropenem was superior to SOC in terms of success at TOC, short term hearing disturbances, safety or mortality were similar in both treatment arms but the study was underpowered to detect the planned effect. Meropenem treatment did not select for colonization with CRGNOs. We suggest that meropenem as broad-spectrum antibiotic should be reserved for neonates who are more likely to have Gram-negative LOS, especially in NICUs where microorganisms producing extended spectrum- and AmpC type beta-lactamases are circulating.

Neonatal Sepsis

Standard of care

10.1371/journal.pone.0229380

Cite

Citations (46)

Antifungal Drug Usage in European Neonatal Units: A Multicenter Weekly Point Prevalence Study

The Pediatric Infectious Disease Journal (2024)

Elisavet Chorafa Εlias Iosifidis Andrea Oletto Adilia Warris Elio Castagnola

Background: Data on antifungal prescribing in neonatal patients are limited to either single-center or single-country studies or to 1-day recording. Therefore, we assessed antifungal longitudinal usage in neonatal units (NUs) within Europe. Methods: CALYPSO, a prospective weekly point prevalence study on antifungal drug usage in NUs in 18 hospitals (8 European countries), was conducted in 2020 during a 12-week period. All patients receiving systemic antifungals were included. Ward demographics were collected at the beginning; ward and patient data including indication, risk factors and antifungal regimen were weekly collected prospectively. Results: Among 27 participating NUs, 15 (56%) practiced antifungal prophylaxis for neonates with birth weight <1000 g or <1500 g and additional risk factors. In total, 174 patients received antifungals with a median frequency per week of 10.5% ranging from 6.9% to 12.6%. Indication for antifungal prescribing was prophylaxis in 135/174 (78%) courses and treatment in 22% [39 courses (69% empirical, 10% preemptive, 21% targeted)]. Fluconazole was the most frequent systemic agent used both for prophylaxis (133/135) and treatment (15/39, 39%). Among neonates receiving prophylaxis, the most common risk factors were prematurity (119/135, 88%), mechanical ventilation (109/135, 81%) and central vascular catheters (89/135, 66%). However, gestational age <28 weeks was only recorded in 55/135 (41%) courses and birth weight <1000 g in 48/135 (35%). Most common reason for empirical treatment was late-onset sepsis; all 8 targeted courses were prescribed for invasive candidiasis. Conclusion: Antifungal usage in European NUs is driven by prophylaxis and empirical treatment with fluconazole being the most prescribed agent for both indications.

Regimen

Antifungal drugs

Neonatal Sepsis

10.1097/inf.0000000000004445

Cite

Citations (1)