A new kind of superhydrophilic drug-carrying coating was synthesized from dopamine and rapamycin to prevent nasolacrimal duct from obstructing through anti-inflammation, anti-infection and anti-fibrosis regulation. This research provides a versatile surface bioengineering strategy.
Multifunctional coatings that mimic the endothelial function in terms of nitric oxide generation and membrane-bound active heparin species are prepared via the immobilization of cystamine-modified heparin/polyethyleneimine (Hep-Cys/PEI) nanoparticles.
Abstract Piezoresistive composite is one of the promising candidates for wearable and flexible force sensors due to its simple and low‐cost preparation and conformability to various surfaces. However, it is challenging to achieve a wide sensing range and a high sensitivity simultaneously. Herein, it is proposed to use multilevel porous structure to address the conflict between sensing range and pressure sensitivity. The multilevel porous structure consists of alternately stacked polyacrylonitrile nanofibers and silver nanowires. The nanostructure presents a multilevel deformation when increasing the applied pressure. The sensor has a broad sensing range while maintaining its sensitivity. These results show that the pressure sensor has a superior sensitivity (defined by the resistance change ratio per unit pressure) of 0.437 kPa –1 and a wide stress range of 0–48.4 kPa. The unique multilevel porous structure makes the sensor stable, repeatable, and durable even after a test of 8000 cycles. Moreover, the sensor also shows small size and lightweight which can be used to detect the movement of various body motions, including facial muscle movements, vocalization, and joint motions. This work provides an effective strategy to achieve high sensitivity and a broad range of piezoresistive sensor through rationally building a multilevel porous structure.
Through textual research and surveying on officinal varieties of Rhizoma Arisaematis, we considered the following results. The name of Rhizoma Arisaematis is in ceaseless change and its original is in confusion in the development of bencaology history. The original plants as Rhizoma Arisaematis are from many species and have wide distribution. This review can provide important reference for exploitation and utilization of resources and further development of Rhizoma Arisaematis through the discussion of the state of its original plant, distribution and mainstream varieties in the current market.
Abstract Magnesium alloys are biodegradable metals, but high corrosion speed and low histocompatibility after implantation still limit the application as biomedical implants. In this work, a bionic coating concept is put forward via mimicking a continuous “tea stain” formation process, using a layer‐by‐layer approach. Tannic acid (TA) incorporating Mg 2+ ions is used to form a chemical conversion coating on magnesium AZ31 alloy for enhanced corrosion protection and favorable biocompatibility. Thermal oxidation of TA, along with metal–phenol coordination and aggregation, forms an all nanoparticles stacked coating, which is crack‐free, homogeneous, more tight, and dense than the pure TA coating. In electrochemical corrosion tests, pH monitoring, and hydrogen evolution tests, the corrosion rate is effectively decreased for the TA/Mg protected AZ31, which is ascribed to the enriched phenol–metal complex and enhanced connections between the individual nanoparticles. With such green chemistry, the introduction of TA and incorporation of Mg 2+ synergistically endow the basic requirement of corrosion protection, without cytotoxicity to endothelial cells and with a safe hemolysis ratio. Additionally, this bionic coating effectively suppresses the inflammatory response to AZ31. These results convincingly demonstrate the effectiveness of using such coating as a biocompatible barrier for the potential application of biodegradable magnesium implants.
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