S. Biswas

Presidency University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Stafford L. Lightman

University of Bristol

D. S. Jessop

University of Cambridge

G. Baffoe

Queen Charlotte's and Chelsea Hospital

P. Hindocha

IQVIA (United Kingdom)

H.S. Chowdrey

University of Westminster

Sumin Hu

Beijing University of Chinese Medicine

Robert F. Harrison

University of Sheffield

Linda Graves

Queen Charlotte's and Chelsea Hospital

K M Ferguson

University of Arkansas at Fayetteville

Rubia Mondal

Presidency University

Cooperative Institutions

Queen Charlotte's and Chelsea Hospital

Charing Cross Hospital

University of London

Universidad de Londres

University of Bristol

Presidency University

Bristol Royal Infirmary

University College London

Guy's Hospital

King's College Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Difficulties in the preparation and isolation of an I¹²⁵-labelled human prolactin monomer suitable for use in the radioimmunoassay

Journal of Obstetrics and Gynaecology (1980)

S. Biswas G. Baffoe

SummaryExperiments were carried out for iodination of human prolactin (HPr) obtained from the National Institute of Arthritis, Metabolism and Digestive Diseases, USA. Three radioactive protein peaks, presumably an aggregate, a dimer and a monomer of HPr capable of binding to anti-HPr sera were isolated on Sephadex G-100 chromatography. A satisfactory assay for estimation of HPr in serum could be established only with the radioactive monomer as the tracer, although it was possible to get a standard curve with the radioactive aggregate as the tracer. On occasions, the monomer tracer failed to produce a satisfactory standard curve, although it was otherwise indistinguishable from a satisfactory monomer tracer. The solid phase lactoperoxidase method of iodination was found to be the most reliable for the preparation of an I'25-labelled HPr.

Lactoperoxidase

TRACER

Sephadex

Standard curve

10.3109/01443618009067357

Cite

Citations (0)

HUMAN CHORIONIC SOMATO-MAMMOTROPHIN IN SERUM AND URINE IN VARIOUS STAGES OF PREGNANCY: ITS CORRELATION WITH ENZYMES AND OESTROGENS

Journal of Endocrinology (1972)

S. Biswas P. Hindocha C. J. Dewhurst

SUMMARY Human chorionic somato-mammotrophin (HCS) and the activities of heat-stable alkaline phosphatase (HSAP) and cysteine aminopeptidase (CAP) in the serum of normal pregnant women were studied. The hormone and enzymes were detectable at the early stage of pregnancy and all showed an increase with the progress of gestation. A highly significant correlation was found between HCS and activities of HSAP and CAP during all stages of gestation. Human chorionic somato-mammotrophin and oestrogens were measured in the urine of pregnant women. The correlation coefficient between these factors was smaller than that found between serum enzymes and HCS but was still significant.

Positive correlation

10.1677/joe.0.0540251

Cite

Citations (28)

THE EFFECT OF HYPERBARIC OXYGEN ON Δ5-3β-HYDROXYSTEROID DEHYDROGENASE, 11- AND 18-STEROID HYDROXYLASES, AND ON NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE-LINKED DEHYDROGENASES IN ORGAN CULTURES OF RAT ADRENAL GLANDS

Journal of Endocrinology (1969)

R. E. Coupland S. Biswas J. D. B. MacDougall

SUMMARY When organ cultures of rat adrenal glands are exposed to gaseous phases of air and hyperbaric oxygen at 2 atm., Δ 5 -3β-hydroxysteroid dehydrogenase is inactivated in both gaseous phases. During the first 24 hr., inactivation is more rapid in air but after 24 hr. little or no difference in rate is observed and little or no activity remains after 72 hr. Estimates of 11- and 18-steroid hydroxylases after various periods of culture in the two gaseous phases and in the absence of exogenous substrate showed similar rates of inactivation during the first 24 hr. When progesterone was used as an exogenous substrate more enzyme activity remained after 24 hr. culture in hyperbaric oxygen than in air. Little enzyme activity remained after 72 hr. The activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase and iso-citric dehydrogenase fall markedly when organ cultures of rat adrenal glands are incubated for 24 hr. in air and in hyperbaric oxygen at 2 atm. The enzymes were, however, no more sensitive to hyperbaric oxygen than to air.

Organ culture

10.1677/joe.0.0430271

Cite

Citations (0)

Prolactin, growth hormone and alpha-fetoprotein in children with cystic fibrosis

Clinica Chimica Acta (1976)

S. Biswas Arne Norman G. Baffoe Linda Graves

10.1016/0009-8981(76)90130-3

Cite

Citations (16)

Maternal Plasma, Human Placental Lactogen, α‐Fetoprotein, Prolactin and Growth Hormone in Early Pregnancy

International Journal of Gynecology & Obstetrics (1980)

Robert F. Harrison S. Biswas

Human placental lactogen

Placental lactogen

Progestogen

Estriol

10.1002/j.1879-3479.1980.tb00191.x

Cite

Citations (4)

A rapid double-antibody radioimmunoassay for human placentallactogen

Clinica Chimica Acta (1973)

P. Hindocha S. Biswas

10.1016/0009-8981(73)90444-0

Cite

Citations (2)

EFFECTS OF NORETHISTERONE ON PITUITARY AND OVARIAN FUNCTION

European Journal of Endocrinology (1974)

William P. Collins E. N. Koullapis K M Ferguson S. Biswas M. J. H. Sharples

ABSTRACT The effect of norethisterone (17α-ethynyl-17β-hydroxy-19-norandrost-4-en-3-one) on certain aspects of pituitary and ovarian function has been investigated in seven healthy women. Twenty-four urine samples were collected daily throughout control cycles and subsequently during the second cycle of treatment with 0.35 mg/day of norethisterone. LH, FSH and total oestrogens were measured in all urine specimens and the level of pregnanediol-3α-glucuronoside on selected days during the luteal phase. In addition, progesterone, 17-hydroxyprogesterone and oestradiol were determined in peripheral venous plasma nine days after the peak of urinary LH. At the same time, progesterone secretion and metabolism were assessed from the analyses of urinary metabolites following the intravenous administration of labelled progesterone. The results show that, in general, norethisterone at this dose does not affect either the level or pattern of FSH, but in five subjects, there was a variable reduction in the midcycle peak of LH (to 33–85 % of the control value). In six subjects, there was a marked reduction in the levels of urinary pregnanediol (to 8–80% of the control value), plasma progesterone (16–55 %), and the urinary production rate of progesterone (3–51 %). In contrast, the level of urinary oestrogen per cycle was increased to 140–160 % in all subjects and the mean values showed an abnormal cyclical pattern. Changes in the distribution of labelled metabolites during treatment indicated the existence of at least two pools of progesterone metabolism.

Norethisterone

Norethisterone acetate

Gonadotropin

10.1530/acta.0.0750357

Cite

Citations (6)

Neuropeptide Y immunoreactivity in the spleen and thymus of normal rats and following adjuvant-induced arthritis

Neuropeptides (1992)

D. S. Jessop S. Biswas Lidwin D’Souza H.S. Chowdrey Stafford L. Lightman

10.1016/0143-4179(92)90125-g

Cite

Citations (7)

Release of corticotrophin-releasing factor-41, arginine vasopressin and oxytocin from rat fetal hypothalamic cells in culture: response to activation of intracellular second messengers and to corticosteroids

Journal of Endocrinology (1992)

Sumin Hu Lesley Tannahill S. Biswas Stafford L. Lightman

ABSTRACT The effects of the activation of protein kinase A (PKA), protein kinase C (PKC) and corticosteroids were investigated on the release of corticotrophinreleasing factor-41 (CRF), arginine vasopressin (AVP) and oxytocin from rat fetal hypothalamic cells in culture. Both forskolin and PMA (phorbol 12-myristate 13-acetate) increased CRF, AVP and oxytocin release, while dexamethasone and aldosterone only reduced basal secretion of CRF. Both steroids also inhibited forskolin-induced CRF, AVP and oxytocin responses to PMA. These data provide direct evidence for a role for both PKC- and PKA-mediated mechanisms in the regulation of CRF, AVP and oxytocin release and for differential effects of both glucocorticoids and mineralocorticoids on PKA- and PKC-stimulated responses. Journal of Endocrinology (1992) 132, 57–65

Second messenger system

Phorbol

10.1677/joe.0.1320057

Cite

Citations (38)

Neuropeptide Y and tyrosine hydroxylase mRNA levels in the locus coeruleus show similar increases after reserpine treatment

Neuropeptides (1991)

O Föster S. Biswas Stafford L. Lightman

Reserpine

Locus coeruleus

10.1016/0143-4179(91)90105-r

Cite

Citations (9)