Qian Ning

Hunan University

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Shengsong Tang

Ningxia Medical University

Tinghua Hu

First Affiliated Hospital of Xi'an Jiaotong University

Shuo Yu

Second Affiliated Hospital of Xi'an Jiaotong University

Min Meng

Liaocheng People's Hospital

Xinhan Zhao

First Affiliated Hospital of Xi'an Jiaotong University

Zhongmin Sun

First Affiliated Hospital of Xi'an Jiaotong University

Zhongcheng Mo

Guilin Medical University

Cui‐Yun Yu

University of South China

Shan Shao

Capital Medical University

Minna Luo

First Affiliated Hospital of Xi'an Jiaotong University

Cooperative Institutions

First Affiliated Hospital of Xi'an Jiaotong University

University of South China

Xi'an Jiaotong University

Hunan University

Central South University

Meso Scale Discovery (United States)

Sichuan University

Chinese Academy of Sciences

Capital Medical University

Huazhong University of Science and Technology

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Non-coding RNAs: New therapeutic targets and opportunities for hepatocellular carcinoma

Advances in Modern Oncology Research (2016)

Cui‐Yun Yu Qian Ning Zhiping Li Wen Huang Jia Yu

<p align="left">Non-coding RNAs (ncRNA) are RNA molecules without protein coding functions owing to the lack of an open reading frame (ORF). Based on the length, ncRNAs can be divided into long and short ncRNAs; short ncRNAs include miRNAs and piRNAs. Hepatocellular carcinoma (HCC) is among the most frequent forms of cancer worldwide and its incidence is increasing rapidly. Studies have found that ncRNAs are likely to play a crucial role in a variety of biological processes including the pathogenesis and progression of HCC. In this review, we summarized the regulation mechanism and biological functions of ncRNAs in HCC with respect to its application in HCC diagnosis, therapy and prognosis.</p>

10.18282/amor.v2.i1.91

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Citations (1)

Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment

Cancer Letters (2010)

Pei Wang Xinhan Zhao Zhiyu Wang Min Meng Xu Li

Conjugate

Haemolysis

10.1016/j.canlet.2010.06.001

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Citations (88)

Room-temperature, atmospheric plasma needle reduces adenovirus gene expression in HEK 293A host cells

Applied Physics Letters (2011)

Zilan Xiong Xinpei Lu Ya Cao Qian Ning Kostya Ostrikov

Room-temperature, atmospheric-pressure plasma needle treatment is used to effectively minimize the adenovirus (AdV) infectivity as quantified by the dramatic reduction of its gene expression in HEK 293A primary human embryonic kidney cells studied by green fluorescent protein imaging. The AdV titer is reduced by two orders of magnitude within only 8 min of the plasma exposure. This effect is due to longer lifetimes and higher interaction efficacy of the plasma-generated reactive species in confined space exposed to the plasma rather than thermal effects commonly utilized in pathogen inactivation. This generic approach is promising for the next-generation anti-viral treatments and imunotherapies.

HEK 293 cells

Infectivity

10.1063/1.3669534

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Citations (20)

Effect Comparison of the Patients Management before and after Applying Instruction to the Preventing and Curing Type 2 Diabetes in Residential Community Base in Urban Community

Zhongguo quanke yixue (2004)

Qian Ning

Objective To study the effects of type 2 diabetics management in urban community after applying Instruction to the Prevention and Cure of Type2 Diabetes in Residential Community Base.Methods To put 100 patients of the type 2 diabetes from five residential communities of Yuetan Sector, West District, Beijing, under strict medical management according to Instruction to the Prevention and Cure of Type 2 Diabetes in Residential Community Base as the object-patients from July, 2003 to November of 2003, to make comparisons of clinical quota, medical cost and compliance of the patients before and after the management.Results After three and half months, it showed that the HbA1c of the patients fell clearly (P0.05) and the relevant medical cost increased slightly but it does not have much statistical significance(P0.05).Conclusion The application of Instruction to Preventiing and Curing Type 2 Diabetes in Residential Community Base benefits the standardization of management of the type 2 diabetics in urban community, it can help raise the standard of glucose control of the patients while increasing little medical care cost.

Urban community

Diabetes management

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Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Artificial Cells Nanomedicine and Biotechnology (2019)

Guangping Yu Qian Ning Zhongcheng Mo Shengsong Tang

Polymeric micelles (PMs) play a vital role in multidrug co-delivery and cancer treatment. However, the development of intelligent PMs further allows PMs to accurately -target tumour, selectively release cargo multidrug and increase uptake. Therefore, targets, controlled release and uptake of intelligent PMs should be paid more attention to improvement synergistic therapeutic outcomes and minimize side effects. In this review, tumour targeting of co-delivery intelligent PMs and its intracellular trafficking mechanisms were overviewed. And this review provides a comprehensive summarization of several intelligent co-delivery PMs. Such a system could control the multidrug to be released simultaneously or sequentially by special properties of tumour microenvironment (TME) (including acidic PH, redox, overexpressed enzyme, excessive temperature) and external environment trigger. Additionally, limitations, clinical translation and future perspectives of intelligent co-delivery PMs were also being discussed in this article.

Cancer Therapy

10.1080/21691401.2019.1601104

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Purification and characterization of two phosphoglucomutases from Lactococcus lactis subsp. lactis and their regulation in maltose- and glucose-utilizing cells

Journal of Bacteriology (1994)

Qian Ning G. A. Stanley Bärbel Hahn‐Hägerdal Peter Rådström

Two distinct forms of phosphoglucomutase were found in Lactococcus lactis subsp. lactis, strains 19435 and 65.1, growing on maltose: beta-phosphoglucomutase (beta-PGM), which catalyzes the reversible conversion of beta-glucose 1-phosphate to glucose 6-phosphate in the maltose catabolism, and alpha-phosphoglucomutase (alpha-PGM). beta-PGM was purified to more than 90% homogeneity in crude cell extract from maltose-grown lactococci, and polyclonal antisera to the enzyme were prepared. The molecular mass of beta-PGM was estimated by gel filtration to be 28 kDa; its isoelectric point was 4.8. The corresponding values for alpha-PGM were 65 kDa and 4.4, respectively. The expression of both PGM enzymes was investigated under different growth conditions. The specific activity and amount of beta-PGM per milliliter of cell extract increased with time in lactococci grown on maltose, but the enzyme was absent in lactococci grown on glucose, indicating enzyme synthesis to be induced by maltose in the growth medium. When glucose was added to maltose-grown lactococci, both the specific activity and amount of beta-PGM per milliliter of cell extract decreased rapidly. This suggests that synthesis of beta-PGM is repressed by glucose in the medium. Although the specific activity of alpha-PGM did not change during growth on maltose or glucose, lactococcal strain 19435 showed a much higher specific activity of both alpha- and beta-PGM than strain 65.1 when grown on maltose.

Phosphoglucomutase

Alpha-amylase

10.1128/jb.176.17.5304-5311.1994

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Citations (87)

PubMed (2011)

Qian Ning Lei Hou Min Meng Bo‐Rong Pan Xinhan Zhao

Most of the ocular tumors have poor prognosis, and they remain a difficult problem in the area of ophthalmology. With the rapid development of molecular biology and immunologic techniques and the deep research on ocular tumor related genes, it becomes possible to diagnose and treat malignant tumors from the molecular level. The tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor (TNF) super family, is a promising candidate, either alone or in combination with established cancer therapies, since it can initiate apoptosis through the activation of their death receptors. The ability of TRAIL to selectively induce apoptosis of transformed, virus-infected or tumor cells but not normal cells promotes the development of TRAIL-based cancer therapy. Here, we will review TRAIL and its receptors' structure, function, mechanism of action and application in ocular tumors therapy.

10.3980/j.issn.2222-3959.2011.05.18

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Citations (1)

Expression of EphB6 in ovarian serous carcinoma is associated with grade, TNM stage and survival

Journal of Clinical Pathology (2015)

Yun Gu Fengshan Li Qian Ning Chen Xiao Hai Wang

Background Ovarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Despite new medical and surgical advances, the overall 5-year survival for OSC remains poor. There is an important need to determine diagnostic and prognostic markers for this disease. Eph receptors are the largest known family of receptor tyrosines characterised in humans. These receptors are involved in the development and progression of various diseases including cancer. EphB6 contains kinase domains that are altered in several conserved amino acids and is catalytically inactive. The aim of the present study was to correlate the immunohistological expression of EphB6 in a cohort of patients with epithelial ovarian tumours with clinicopathological parameters and survival. Methods In this study we examined the expression of EphB6 protein in 55 cases of OSC, 24 cases of benign ovarian serous tumours, 37 cases of serous borderline tumours and 20 cases with normal fallopian tubes by immunohistochemical staining with a polyclonal anti-EphB6 antibody. The relationship between EphB6 expression and pathological parameters was analysed. Kaplan–Meier survival function was used to analyse the prognosis. Results High expression of EphB6 was observed in 100% (20/20) of normal fallopian tube samples, 100% (24/24) of benign epithelial ovarian tumours, 78% (29/37) of ovarian serous borderline tumours and 18% (10/55) of OSCs (p<0.001). The expression of EphB6 was significantly associated with grade (p<0.001) and TNM stage (p=0.017). EphB6 expression was reversely related to Ki-67 (p=0.021). The survival analysis showed that patients with negative or weak expression of EphB6 protein had a poorer outcome than those with positive expression (p=0.046). Conclusions Our results show that EphB6 is a new biomarker for distinguishing high- and low-grade OSC, and may be a potential prognostic marker in OSCs.

Serous carcinoma

10.1136/jclinpath-2015-203160

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Mechanisms of immune escape in the cancer immune cycle

International Immunopharmacology (2020)

Sha Tang Qian Ning Ling Yang Zhongcheng Mo Shengsong Tang

Evasion (ethics)

Immune escape

Cancer Immunotherapy

10.1016/j.intimp.2020.106700

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Citations (122)

Ganoderic Acid A suppresses the phenotypic modulation of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension

Food Science and Technology (2021)

Yan Meng Qian Ning Ya Liu Yamei Pang Hui Ren

Ganoderic acid A (GAA) is one of the most abundant triterpenoids in Ganoderma lucidum and has protective effect on several vascular diseases. However, the effect of GAA on pulmonary arterial hypertension (PAH) has not been reported. The aim of this study was to investigate the effect of the GAA on the hypoxia-induced phenotypic modulation of PASMCs and the involved transduction pathway. Primary rat pulmonary artery smooth muscle cells (PASMCs) were isolated and cultured under hypoxia condition to induce phenotypic modulation. Our results showed that hypoxia significantly increased the proliferation and migration of PASMCs, as well as inhibited the apoptosis of PASMCs, which were blocked by GAA treatment. In addition, hypoxia-induced dedifferentiation of PASMCs was prevented by GAA with increased the expression levels of myocardin and calponin, and decreased the expression of osteopontin (OPN). Furthermore, GAA suppressed the hypoxia-induced expression of p-PI3K and p-Akt in PASMCs. Treatment with IGF-1 reversed the effects of GAA on proliferation, migration, apoptosis and dedifferentiation in hypoxia-treated PASMCs. Taken together, these findings demonstrated that GAA suppresses the phenotypic modulation of PASMCs through the inactivation of PI3K/Akt pathway. Thus, GAA may be a potent therapeutic agent for PAH in future clinical practice.

Myocardin

Hypoxia

Calponin

Osteopontin

10.1590/fst.83221

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Citations (5)