Vishwa Mohan Katoch

Rajasthan University of Health Sciences

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Raja Babu Panwar

Delhi Pharmaceutical Science and Research University

Rajeev Gupta

Eternal Hospital

Vaseem Naheed Baig

Rajasthan University of Health Sciences

Arvind Sharma

Career Point University

Sonali Sharma

Rajasthan University of Health Sciences

Jyotsna Joshi

Topiwala National Medical College & BYL Nair Charitable Hospital

Manvir Bhatia

All India Institute of Medical Sciences

Garima Shukla

Thomas Jefferson University

Kapil Sikka

All India Institute of Medical Sciences

Alladi Mohan

Sri Venkateswara Institute of Medical Sciences

Cooperative Institutions

All India Institute of Medical Sciences

Rajasthan University of Health Sciences

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

Indian Council of Medical Research

College of Medical Sciences

Post Graduate Institute of Medical Education and Research

All India Institute of Medical Sciences Raipur

All India Institute of Medical Sciences Bhopal

SRM University

Chang Gung University

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Detection of Mycobacterium leprae DNA for 36kDa protein in urine from leprosy patients: a preliminary report

Revista do Instituto de Medicina Tropical de São Paulo (2004)

Om Parkash Hari Bhan Singh Subha Rai Archna Pandey Vishwa Mohan Katoch

We have searched for Mycobacterium leprae DNA for 36kDa protein in urine using a M. leprae specific PCR technique. A limited number of 16 patients (of which 11 belonged to lepromatous leprosy and five to tuberculoid leprosy) and eight healthy individuals were included for the present study. The number of urine samples positive by PCR were 36.4% (4/11) in lepromatous patients and 40% (2/5) in tuberculoid patients. None of the samples from healthy individuals was positive. To our knowledge, the results indicate, for the first time, the presence of M. leprae DNA in urine from leprosy patients. Another important finding obtained out of the study is that amongst treated patients 66.6% (4/6) were positive whereas amongst untreated only 20% (2/10) were positive. From the present indicative data it appears that treatment improves the PCR results with urine as a sample. Thus, the approach could prove to be useful for monitoring the treatment response of individual patients and needs to be further evaluated with a large number of patients.

Mycobacterium leprae

Tuberculoid leprosy

10.1590/s0036-46652004000500008

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Citations (15)

Applications of Molecular Methods in Human Medicine in India-Urgency to Bridge the Gap

RUHS Journal of Health Science (2018)

Vishwa Mohan Katoch

Bridge (graph theory)

10.37821/ruhsjhs.3.3.2018.119-120

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Molecular Basis of Drug Resistance in Mycobacteria

Springer eBooks (2019)

Vishwa Mohan Katoch

INHA

Clofazimine

Ethionamide

rpoB

23S ribosomal RNA

Efflux

Antimycobacterial

10.1007/978-981-32-9449-3_1

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Citations (2)

IS THERE A MICROBIOLOGICAL RATIONALE FOR SINGLE-DOSE TREAMENT OF LEPROSY?

Leprosy Review (1998)

Vishwa Mohan Katoch

10.5935/0305-7518.19980002

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Consensus & Evidence-based INOSA Guidelines 2014 (First edition).

PubMed (2015)

Surendra Kumar Sharma Vishwa Mohan Katoch Alladi Mohan Tamilarasu Kadhiravan Arunmozhimaran Elavarasi

Obstructive sleep apnoea (OSA) and obstructive sleep apnoea syndrome (OSAS) are subsets of sleep-disordered breathing. Awareness about OSA and its consequences amongst the general public as well as the majority of primary care physcians across India is poor. This necessiated the development of the INdian initiative on Obstructive Sleep Apnoea (INOSA) guidelines under the auspices of Department of Health Research, Ministry of Health & Family Welfare, Government of India. OSA is the occurrence of an average five or more episodes of obstructive respiratory events per hour of sleep with either sleep related symptoms or comorbidities or ≥ 15 such episodes without any sleep related symptoms or comorbidities. OSAS is defined as OSA associated with daytime symptoms, most often excessive sleepiness. Patients undergoing routine health check-up with snoring, daytime sleepiness, obesity, hypertension, motor vehicular accidents and high risk cases should undergo a comprehensive sleep evaluation. Medical examiners evaluating drivers, air pilots, railway drivers and heavy machinery workers should be educated about OSA and should comprehensively evaluate applicants for OSA. Those suspected to have OSA on comprehensive sleep evaluation should be referred for a sleep study. Supervised overnight polysomnography (PSG) is the "gold standard" for evaluation of OSA. Positive airway pressure (PAP) therapy is the mainstay of treatment of OSA. Oral appliances are indicated for use in patients with mild to moderate OSA who prefer oral appliances to PAP, or who do not respond to PAP or who fail treatment attempts with PAP or behavioural measures. Surgical treatment is recommended in patients who have failed or are intolerant to PAP therapy.

Sleep

Positive airway pressure

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Association of Toll like receptor 2 and 9 gene variants with pulmonary tuberculosis: exploration in a northern Indian population

Molecular Biology Reports (2018)

Mayank Mittal Sanjay Biswas Vandana Singh Nidhi Arela Vishwa Mohan Katoch

Association (psychology)

10.1007/s11033-018-4182-z

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Potential of nanoparticles encapsulated drugs for possible inhibition of the antimicrobial resistance development

Biomedicine & Pharmacotherapy (2021)

Ramendra Pati Pandey Riya Mukherjee Anjali Priyadarshini Archana Gupta Arpana Vibhuti

The immune system is a dynamic network of cells and cytokines are the major mediators of immune responses which combat pathogens. Based on the cytokine production, effector T cells differentiate into subsets known as Th1, Th2, Th17, or Treg. This system serves as a barrier to intracellular pathogens, bacterial infections and stimulates the production of reactive oxygen species (ROS), reactive nitrogen intermediates, and nitric oxide, which diffuses across membranes and engulfs intracellular pathogens. Oxidative stress occurs when ROS, reactive nitrogen species (RNS) production, and antioxidant defences become imbalanced. Oxidative stress generated by infected cells produces a substantial amount of free radicals which enables the killing of intracellular pathogens. Intracellular pathogens are exposed to endogenous ROS as part of normal aerobic respiration, also exogenous ROS and RNS are generated by the host immune system in response to infection. Nanoparticles which are designed for drug delivery are capable of trapping the desired drug in the particles which protect the drug from enzymatic degradation in a biological system. The subcellular size of nanoparticles enables higher intracellular uptake of the drug which results in the reduction of the concentration of free drugs reducing their toxic effect. Research on the modulation of immune response and oxidative stress using nanoparticles used to encapsulate drugs has yet to be explored fully. In this review, we illustrate the immune activation and generation of oxidative stress properties which are mediated by nanoparticle encapsulated drug delivery systems which can make the therapy more effective in case of diseases caused by intracellular pathogens.

Reactive nitrogen species

Intracellular parasite

10.1016/j.biopha.2021.111943

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Citations (19)

Consensus & Evidence-based INOSA Guidelines 2014 (First edition)

The Indian Journal of Chest Diseases and Allied Sciences (2022)

Alladi Mohan Suresh Kumar Rajendra Prasad Garima Shukla Dipti Gothi

Consensus conference

10.5005/ijcdas-57-1-48

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Citations (2)