Shougang Guo

Shandong Provincial Hospital

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Chunjuan Wang

Capital Medical University

Baojie Wang

Chinese Academy of Sciences

Ziling Zeng

Nanyang Technological University

Lirui Tu

Shanghai Public Health Clinical Center

Yunjun Yan

Huazhong University of Science and Technology

Chunjuan Wang

Shihezi University

Chuanqiang Qu

Shandong Provincial Hospital

Xiaodong Qiao

Chifeng University

Wei Yue

Tianjin Huanhu Hospital

Jingyao Zhang

Air Force Medical University

Cooperative Institutions

Shandong University

Shandong Provincial Hospital

Shandong First Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Jilin University

Chinese Academy of Sciences

Capital Medical University

Peking University

Huazhong University of Science and Technology

Southern Medical University

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Dyslipidemia in severe fever with thrombocytopenia syndrome patients: A retrospective cohort study

PLoS neglected tropical diseases (2024)

Shuai Guo Jingliang Zhang Qing Dong Yunjun Yan Chunjuan Wang

Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressive infectious disease triggered by a novel bunyavirus (SFTSV). Despite the critical role of host lipid metabolism in viral infections, research on dyslipidemia in SFTS remains limited.

Dyslipidemia

10.1371/journal.pntd.0012673

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[LINGO-1 expression of brain tissue in experimental autoimmune encephalomyelitis mouse].

PubMed (2014)

Chunjuan Wang Shougang Guo Chuanqiang Qu Jie Zhang Peicai Fu

To observe the changes of LINGO-1 expression with time after onset in EAE mouse.C57/BL6 mice were completely randomly divided into EAE model group (n = 15) , adjuvant group (n = 15) and control group (n = 15) .LINGO-1 expression of brain tissue was detected on day 1, 7, 14, 21 and 30 after onset by RT-PCR and Western blot.RhoA and p-RhoA expression of brain tissue was analysed by Western blot.The LINGO-1mRNA levels in EAE model group were markedly higher than control group on day 1, 7and 14 after onset (4.63 ± 0.25, 2.72 ± 0.12, 1.98 ± 0.16, P < 0.01, P < 0.01, P < 0.05).On day 30, Lingo-1 mRNA was close to control group.Expression levels of Lingo-1 protein on day 1, 7, 14, 21, 30 were higher than control group (2.11 ± 0.15, 3.15 ± 0.09, 2.45 ± 0.12, 1.89 ± 0.17, 1.21 ± 0.05, P < 0.05, P < 0.01, P < 0.05, P < 0.05, P < 0.05. The levels of p-RhoA protein increased in EAE and the peak appeared on day 1 and day 7 (P < 0.01) . And there was no difference on RhoA expression among different groups.LINGO-1 expression of brain tissue of EAE mouse upregulates and changes with time after onset, which may inhibit myelination by RhoA activation.In clinic, the antagonist of LINGO-1 for MS should be applied as soon as possible.

Brain tissue

Encephalomyelitis

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Analysis of clinical features, serologic and cerebrospinal fluid tests in patients with neurosyphilis at different stages

DOAJ (DOAJ: Directory of Open Access Journals) (2016)

Baojie Wang Chun-juan Wang Hao Sun Shougang Guo

Objective To summarize the clinical features, serologic, cerebrospinal fluid (CSF) tests in patients with neurosyphilis at different stages. Methods A retrospective analysis was made on the clinical features, imaging, serologic and CSF tests, treatment and prognosis of 12 cases diagnosed as neurosyphilis. In those cases, 5 cases were early-stage neurosyphilis, including 4 syphilitic meningitis (meningomyelitis) and one meningovascular syphilis; 7 cases were late-stage neurosyphilis, all of whom were general paresis. Results The serum Treponema pallidum antibody (TP-Ab) and rapid plasma regain (RPR) tests were positive in all 12 cases. The CSF TP-Ab tests of 12 cases were all positive and CSF RPR tests were positive in 9 cases. In 5 cases of early-stage neurosyphilis, one case had elevated intracranial pressure (ICP), 3 cases presented with elevated white blood cell (WBC), 4 cases had elevated protein concentration. In 7 cases of late-stage neurosyphilis, one case had elevated ICP, 7 cases presented with elevated WBC and protein concentration. CSF cytology showed lymphocyte reaction, mainly small lymphocytes. All cases were treated with different doses of intravenous penicillin or ceftriaxone sodium by intramuscular injection, among whom 8 cases presented improved neuropsychiatric symptoms, while 4 cases had no significant improvement. Conclusions Neurosyphilis is easy to be misdiagnosed because of various styles of onset and nontypical clinical manifestations. A definite diagnosis depends on clinical manifestations and serologic and CSF examinations. Early diagnosis and standard treatment is essential for improving prognosis and reducing complications. DOI: 10.3969/j.issn.1672-6731.2016.07.005

Neurosyphilis

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Clinical and pathological features of cerebrospinal meningitis caused by Pantoea agglomerans : a case report

BMC Infectious Diseases (2024)

Honghao Li Jing Yu Ziling Zeng Cuicui Liu Zhang Ye

Pantoea agglomerans (P. agglomerans) is a gram-negative bacterium that is commonly isolated from plant surfaces, seeds, and the environment. As an opportunistic pathogen, it can cause blood, urinary and soft tissue infections in immunocompromised patients. In central nervous system, P. agglomerans infection has been report in children and immune-compromised patients, however, infection by such bacterium in nontraumatized immune competent adults has not been reported. Here, we report a case of P. agglomerans cerebrospinal meningitis accompanied by positive anti-myeloperoxidase (MPO) antibody in a 49-year-old female who has a history of black fungus planting. The patient manifested with repeated fever, headache, generalized muscle pain, and neurological defects. Cerebrospinal fluid (CSF) tests revealed a moderately elevated number of polymorphonuclear leukocytes (50–193 × 106/L), low glucose levels (0.54–2.44 mmo1/L), and extremely high protein content (2.42–25.42 g/L). Blood tests showed positive anti-myeloperoxidase antibodies lasting for 1.5 year before turning negative. Spine MRI showed thickening and enhancement of the whole spinal meninges. CSF metagenomic next-generation sequencing (mNGS) revealed 75,189 specific DNA reads of P. agglomerans. The patient underwent spinal laminectomy due to meningeal adhesions. Pathological results revealed fibrous tissue proliferation, inflammatory infiltration with focal necrosis and calcification in the dura mater. The patient was successfully treated with sufficient antibiotics at 1-year follow-up. People should be alert to CNS infections caused by P. agglomerans which presented with relatively mild clinical symptoms at onset, especially for those who contucts relevant agricultural and forestry work. The CSF characterization of P. agglomerans meningitis is elevated multiple nuclei white blood cells, significantly reduced glucose content, and markedly increased protein level which may be related to the secondary spinal membrane adhesions.

Medical microbiology

Pantoea agglomerans

10.1186/s12879-024-10035-6

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Metagenomic Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Central Nervous System Infections: A Multicentre Cohort Study

Research Square (Research Square) (2019)

Siyuan Fan Xiaojuan Wang Yafang Hu Jingping Shi Yueli Zou

Abstract Background: Infectious encephalitis and meningitis are often treated empirically without identification of the causative pathogen, even if comprehensive conventional diagnostic technologies are applied. Metagenomic next-generation sequencing (mNGS) is a high throughput technology that enables the detection of pathogens independent of prior clinical or laboratory information.Methods: The present study was a multicentre prospective evaluation of mNGS of cerebrospinal fluid (CSF) for the diagnosis of suspected central nervous system infections in China, where routine PCR was not widely used. Results: A total of 276 patients were enrolled in this study between Jan 1, 2017 and Jan 1, 2018. Identification of an aetiologic pathogen in CSF by mNGS was achieved in 101 patients (36.6%). mNGS detected 11 bacterial species, 7 viral species, 2 fungal species, and 2 parasitic species. The leading positive detections were Mycobacterium tuberculosis (14), Listeria monocytogenes (8), Brucella (7), varicella-zoster virus (17), herpes simplex virus 1 (12), Epstein-Barr virus (12), and Cryptococcus neoformans (7). False positives occurred in 12 (4.3%) patients with bacterial infections known to be widespread in hospital environments. False negatives occurred in 16 (5.8%) patients and included bacterial, viral and fungal aetiologies. Conclusions: This study shows that mNGS of CSF is a powerful diagnostic method to identify the pathogen for many central nervous system infections. The result of mNGS should be interpreted with clinical information sometimes.

Viral meningitis

10.21203/rs.2.17334/v1

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Serum lipidome reveals lipid metabolic dysregulation in severe fever with thrombocytopenia syndrome

BMC Medicine (2024)

Shuai Guo Yunjun Yan Jingyao Zhang Zhangong Yang Lirui Tu

Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressing infectious disease with a high fatality rate caused by a novel bunyavirus (SFTSV). The role of lipids in viral infections is well-documented; however, the specific alterations in lipid metabolism during SFTSV infection remain elusive. This study aims to elucidate the lipid metabolic dysregulations in the early stages of SFTS patients. This study prospectively collected peripheral blood sera from 11 critical SFTS patients, 37 mild SFTS patients, and 23 healthy controls during the early stages of infection for lipidomics analysis. A systematic bioinformatics analysis was conducted from three aspects integrating lipid differential expressions, lipid differential correlations, and lipid-clinical indices correlations to reveal the serum lipid metabolic dysregulation in SFTSV-infected individuals. Our findings reveal significant lipid metabolic dysregulation in SFTS patients. Specifically, compared to healthy controls, SFTS patients exhibited three distinct modes of lipid differential expression: increased levels of lipids including phosphatidylserine (PS), hexosylceramide (HexCer), and triglycerides (TG); decreased levels of lipids including lysophosphatidylcholine (LPC), acylcarnitine (AcCa), and cholesterol esters (ChE); and lipids showing "dual changes" including phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Finally, based on lipid metabolic pathways and literature analysis, we systematically elucidated the potential mechanisms underlying lipid metabolic dysregulation in the early stage of SFTSV infection. Our study presents the first global serum lipidome profile and reveals the lipid metabolic dysregulation patterns in the early stage of SFTSV infection. These findings provide a new basis for the diagnosis, treatment, and further investigation of the disease.

Lipidome

Immune Dysregulation

10.1186/s12916-024-03672-w

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CT Manifestations of Osler-Weber-Rendu Syndrome in Liver: Report of Three Cases

Journal of Clinical Imaging Science (2012)

Chuanqiang Qu Shougang Guo He Yan Yuxin Chen

Osler-Weber-Rendu syndrome is characterized by widespread telangiectasias. Its clinical manifestations depend on position and scope of the abnormal vessels. The clinical and CT data of 3 patients with Osler-Weber-Rendu syndrome were retrospectively analyzed. CT features reviewed include the change of volume and configuration of liver, presence of tortuous and irregular vessels, opacified vessel mass, arteriovenous shunt, and splenomegaly. CT is helpful for diagnosis, treatment, and follow-up of Osler-Weber-Rendu syndrome.

10.4103/2156-7514.96541

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Follow-up of a Rickettsia felis encephalitis: Some new insights into clinical and imaging features

International Journal of Infectious Diseases (2021)

Ziling Zeng Chunjuan Wang Cuicui Liu Baojie Wang Xin Meng

Rickettsia felis (R. felis) infection is a cause of unspecified encephalitis. However, the incidence has been underestimated due to the intracellular features of the pathogen and insufficient understanding of its clinical picture. This study reported a case of R. felis infection in a 26-year-old female who only manifested with certain neurological symptoms. With a lack of specific systemic inflammatory symptoms, the diagnosis was initially misdiagnosed as a brain glioma. However, a brain tissue biopsy showed prominent perivascular inflammatory infiltrations, which indicated inflammatory disease. Spinal fluid metagenomic next-generation sequencing (mNGS) was taken after ruling out other common infectious and autoimmune diseases. The results suggested R. felis infection, which was also supported by Weil-Felix reaction in the serum. After the diagnosis was corrected as R. felis encephalitis, the patient was successfully treated with doxycycline and had a good prognosis at the 1-year follow-up.

10.1016/j.ijid.2020.12.090

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Citations (6)