Abstract A sandwich enzyme‐linked immunosorbent assay was developed to detect ciguatoxin (CTX) in fish tissue. The assay utilizes two antibodies, chicken immunoglobulin Y specific to the ABCD domain of CTX and a mouse monoclonal immunoglobulin G–hor‐seradish peroxidase conjugate specific to the JKLM domain of CTX. The sensitivity, working range, cross reactivity, accuracy, precision, and reproducibility were examined. J. Clin. Lab. Anal. 22:239–245, 2008. © 2008 Wiley‐Liss, Inc.

Horseradish peroxidase

Ciguatoxin

Conjugate

Cross-reactivity

10.1002/jcla.20256

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Citations (29)

STUDIES ON THE BIOLUMINESCENT MECHANISM OF SYMPLECTIN PHOTOPROTEIN

Minoru Isobe Takeshi Matsuda Masaki Kuse Hisashi Mori Tatsuya Fujii

Photoprotein

10.1142/9789812702203_0002

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Citations (0)

Enantiomeric synthesis of pyran subunits of marine trans-fused polyether toxins :Epimerization of Alkynyl sugars through cobalt complexes

Tetrahedron (1994)

Shigeyoshi Tanaka Minoru Isobe

Epimer

Pyranose

Pyran

10.1016/s0040-4020(01)85634-9

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Citations (57)

ChemInform Abstract: Synthesis of a Diterpene Taxoid Skeleton, Bicyclo[9.3.1]pentadecatriene.

ChemInform (1998)

Satoshi Shibuya Minoru Isobe

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Taxoid

Skeleton (computer programming)

10.1002/chin.199841181

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Citations (0)

Synthetic studies on tetrodotoxin (1) stereocontrolled synthesis of the cyclohexane moiety

Tetrahedron Letters (1987)

Minoru Isobe Toshio Nishikawa Stanisław Pikul Toshio Goto

Moiety

Neurotoxin

Tetrodotoxin

10.1016/s0040-4039(00)96895-3

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Citations (35)

ChemInform Abstract: Synthesis and Activity of Cereulide, a Cyclic Dodecadepsipeptide Ionophore as Emetic Toxin from Bacillus cereus.

ChemInform (1996)

Minoru Isobe Tetsuya Ishikawa Sathorn Suwan Norio Agata M Ohta

10.1002/chin.199614223

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Citations (0)

Antifungal Azaphilones from the Fungus Chaetomium cupreum CC3003

Journal of Natural Products (2006)

Somdej Kanokmedhakul Kwanjai Kanokmedhakul Pitak Nasomjai Sysavad Louangsysouphanh Kasem Soytong

Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50 values of 10.5, 16.7, 24.3, and 0.6 microg/mL, respectively.

Chaetomium

Derivative (finance)

Absolute Configuration

10.1021/np060051v

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Citations (109)

Total Synthesis of GD_3, A Ganglioside

Chemistry Letters (1996)

Tadao Kondo Toshiyuki Tomoo Hiroyuki Abé Minoru Isobe Toshio Goto

Ganglioside

Source

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Highly Regioselective Hydrosilylation of Unsymmetric Alkynes Using a Phenylthio Directing Group

European Journal of Organic Chemistry (2014)

Kuan‐Hsun Huang Minoru Isobe

Abstract Cobalt‐assisted hydrosilylation of acetylenes is particularly interesting in organic synthesis since alkynyl group functionalization can give way to more useful substructures. This study aims to answer the general question of how to control hydrosilylation regioselectivity with unsymmetric alkynyl groups. Cobalt‐catalyzed hydrosilylation is highly regioselective with alkyl‐phenylthio‐acetylenes affording corresponding cis ‐α‐silyl‐α‐thioaryl‐substituted olefins. However, this reaction loses regioselectivity in cases involving substrates with relatively small alkyl groups. The roles of the directing group in this reaction are to (i) exert steric effects on the alkyl group, and (ii) express stereoelectronic effects of the sulfur or oxygen atom. The scope and limitation of the hydrosilylation as well as the role of such a directing group are discussed.

Hydrosilylation

Functional group

10.1002/ejoc.201402577

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Citations (50)