Xiaodan Han

Jiangxi Academy of Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Yu‐Long Zhao

Northeast Normal University

Jianping Fu

Ministry of Ecology and Environment

Junling Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Huibin Wang

Anhui University of Science and Technology

Saijun Fan

Chinese Academy of Medical Sciences & Peking Union Medical College

Qun Liu

Wuhan Textile University

Xiaolei Xue

Southern Medical University

Wei Xiong

University of Macau

Chuan‐Qing Ren

Shaanxi University of Technology

Huajiao Li

Ministry of Natural Resources

Cooperative Institutions

Fudan University

Sun Yat-sen University

Zhongshan Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

The First Affiliated Hospital, Sun Yat-sen University

Chinese Academy of Sciences

Jiangxi Academy of Sciences

Shanghai Jiao Tong University

China University of Geosciences (Beijing)

Ministry of Natural Resources

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Hydrogen-rich water alleviates radiation-induced injury to hematopoietic stem and progenitor cells

Xiaodan Han Xiaolei Xue Junling Zhang Saijun Fan

Objective To investigate the protective effect of hydrogen-rich water (HRW) on radiation-induced hematopoietic stem and progenitor cells (HSPCs) injury. Methods Totally 32 C57BL/6 mice were randomly divided into four groups with 8 mice in each group, including control, HRW, radiation and radiation + HRW. Mice in HRW and radiation + HRW groups received 0.5 ml hydrogen-rich water per day by intragastric administration 5 min before irradiation until 7 d post-irradiation. Mice in other groups received 0.5 ml distilled water. Mice in radiation and radiation + HRW group were irradiated with 2 Gy of total body irradiation. Bone marrow cells were isolated at 15 d post-irradiation, and LSK cells were examined for the percentage of hematopoietic stem and progenitor cells, the ability of colony formation and reconstitution, reactive oxygen species (ROS) levels and cell apoptosis. Results Compared with radiation group, the percentages of hematopoietic progenitor cells and LSK cells, colony number of bone marrow cells were significantly increased in radiation + HRW group (t=-4.935, -7.898, 5.488, P<0.05). An elevation of donor chimerism was also found in recipient mice administered HRW after competitive bone marrow transplantation (t=-12.769, P<0.05). Compared with radiation group, the ROS levels and cell apoptosis in LSK cells were significantly decreased (t=4.380, 3.954, P<0.05). Conclusions Hydrogen-rich water exhibited a protective effect on radiation-induced HSPCs injury. Key words: Hydrogen-rich water; Ionizing radiation; Hematopoietic stem and progenitor cells; Reactive oxygen species

10.3760/cma.j.issn.0254-5098.2017.05.002

Cite

Citations (0)

CCDC 781521: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

Yu-Long Zhao Shao-Chun Yang Chong-Hui Di Xiaodan Han Qun Liu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccv77cn

Cite

Citations (0)

The short-term price effects and transmission mechanism of CO2 cost pass-through in China: A partial transmission model

Resources Policy (2021)

Ning Ma Huajiao Li Jinwei Zhang Xiaodan Han Sida Feng

Partial equilibrium

Carbon tax

10.1016/j.resourpol.2020.101972

Cite

Citations (11)

CCDC 1948958: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Xiaodan Han Gaoliang Peng Huibin Wang Lei Wu Jianping Fu

10.5517/ccdc.csd.cc23f1m7

Cite

Citations (0)

Positive Impact of Intraoperative Epidural Ropivacaine Infusion on Oncologic Outcomes in Pancreatic Cancer Patients Undergoing Pancreatectomy: A Retrospective Cohort Study

Journal of Cancer (2021)

Wannan Chen Yaolin Xu Yueming Zhang Wenhui Lou Xiaodan Han

Background: Previous literatures have demonstrated that regional anesthesia such as epidural anesthesia may affect long-term survival of cancer patients.In the present study, we conducted a retrospective cohort study to investigate the survival impact of intraoperatively epidural ropivacaine infusion on pancreatic ductal adenocarcinoma (PDAC) patients.Methods: PDAC patients who underwent pancreatic surgery in Zhongshan Hospital Fudan University from January, 2015 to June, 2018 were included.The surgical procedure was performed under combined endotracheal general anesthesia and thoracic epidural anesthesia, and patient-controlled epidural analgesia (PCEA) with 0.12% ropivacaine was given after surgery for further pain control.Patients were divided into two groups according to their intraoperative epidural ropivacaine concentration: high (0.375%-0.5%) and low (0.15%-0.25%).Survival outcome was compared between groups.Results: A total of 215 patients were enrolled and their baseline characteristics were balanced between groups, except that patients with high concentration ropivacaine received higher total dose opioid and had longer operative time.Resected PDAC patients who were administrated with high concentration ropivacaine through epidural catheter intraoperatively had improved overall survival (median overall survival, mOS, high VS low, 37.6 VS 23.7 months, p=0.04).High epidural ropivacaine concentration was an independent prognostic factor (hazard ratio [HR]=0.65,95% confidence interval [CI], 0.44-0.94;p=0.03).Subgroups analyses shown that T3M0 PDAC patients with preoperative CA 19-9 higher than 200 U/ml, negative resection margin, and those without tumor deposit and adjuvant radiotherapy could benefit from high concentration of ropivacaine.Conclusion: Intraoperatively epidural infusion with high concentration of ropivacaine was associated with improved OS in PDAC patients undergoing pancreatectomy.

Ropivacaine

10.7150/jca.57661

Cite

Citations (10)

Proton‐Promoted Hydroamination of 3‐Dialkylthiomethylene‐1,4‐pentadiynes with o‐Phenylenediamines: A Facile Route to Benzo[b][1,4]diazepines

Advanced Synthesis & Catalysis (2008)

Yu‐Long Zhao Dazhi Li Xiaodan Han Li Chen Qun Liu

Abstract The first proton‐promoted intermolecular hydroamination reaction of the enynes, α,α‐dialkynylketene S,S ‐acetals 2 , is described. A series of benzo[ b ][1,4]diazepines, with the structures of 3 and 5 , were prepared chemo‐ and regioselectively in good to high yields by reacting the readily available 1,4‐diynes 2 with both terminal and internal alkyne functions with o ‐phenylenediamines under very mild conditions.

Hydroamination

Alkyne

10.1002/adsc.200700547

Cite

Citations (10)

Clinical Research on the Treatment of Simple Obesity by Oral Chinese Medicine Combined with Health Education to Improve Phlegm Dampness Constitution

Chuan Yu Bin Shen S. Xu Zezong Gu Linlin Xu

Phlegm

10.70976/j.2096-0964.2018.2.19-23

Cite

Citations (0)

CCDC 849110: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Xiaodan Han Yu‐Long Zhao Jia Meng Chuan‐Qing Ren Qun Liu

10.5517/ccxhknl

Cite

Citations (0)

Learnable color space conversion and fusion for stain normalization in pathology images

Medical Image Analysis (2024)

Jing Ke Yijin Zhou Yiqing Shen Yi Guo Ning Liu

Normalization

Stain

Digital Pathology

Hue

10.1016/j.media.2024.103424

Cite

Citations (0)

The Effects of Erector Spinae Plane Block on Perioperative Opioid Consumption and Rehabilitation in Video Assisted Thoracic Surgery

Research Square (Research Square) (2021)

Sen Zhang Xiaodan Han Di Zhou Minli Sun Jing Cang

Abstract Background The present study aimed to observe whether the ultrasound-guided continuous erector spinae plane block (ESPB) has an effect on opioid consumption and postoperative rehabilitation in patients who undergo video-assisted thoracic surgery (VATS). Methods In this prospective study, 120 patients aged 20–70 yrs, undergoing elective VATS, were randomly allocated to one of three groups: Group C (General anaesthesia with patient-controlled intravenous analgesia [PCIA]), Group T (General anaesthesia with patient-controlled epidural analgesia [PCEA]), or Group E (General anaesthesia with continuous ESPB and PCIA). The perioperative opioid consumption; VAS scores; preoperative and postoperative QoR-15 score; and postoperative opioid-related adverse events were all assessed. Results The intraoperative sufentanil consumption in group T and E was significantly lower than that in group C (both P < 0.001 ), and the postoperative sufentanil consumption in group E was also significantly lower than that of group C ( P = 0.001 ). Compared with group C, the VAS scores at rest or during coughing immediately out of the post-anesthesia care unit (PACU), at postoperative 6h, 12h, and 24h, were significantly lower in group T ( P < 0.05). However, the VAS scores in group E were lower than those of group C only at rest at postoperative 6h and 12h ( P < 0.05), and were significantly higher than those of group T at all study times ( P < 0.05). Conclusion Ultrasound-guided continuous ESPB could significantly reduce perioperative opioid consumption in VATS and improve postoperative rehabilitation. However, these effects were inferior to those provided by TEA. Trial registration The present study was prospectively registered at http://www.chictr.org/cn /(Registration number: ChiCTR1900023050); Registration date: May 8,2019

Sufentanil

10.21203/rs.3.rs-406829/v1

Cite

Citations (0)