Mahmoud Abdelaal

Sinai University

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Mohamed Alaa

Cairo University

Osama Taha

Assiut University

Mohamed Abozeid

Ain Shams University

Samia Saied

Sohag University

Osama Taha

Assiut University

Mohamed Talaat

University of Massachusetts Lowell

Mohamed Shoeib

Menoufia University

Awny Asklany

Assiut University

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Assiut University

Cairo University

Central Laboratory For Agricultural Expert Systems

Sohag University

Ain Shams University

Al-Azhar University

Mansoura University

Alexandria University

National University of Singapore

Universidade do Porto

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The Outcomes of Revisional One Anastomosis Gastric Bypass Versus Revisional Roux-en-Y Gastric Bypass After Primary Restrictive Procedures: A Prospective Nonrandomized Comparative Study

Bariatric Surgical Practice and Patient Care (2021)

Osama Taha Mahmoud Abdelaal Awny Asklany Mohamed Alaa

Background: Failed restrictive procedures are usually managed with conversion to another bariatric procedure. Our aim was to evaluate one -anastomosis gastric bypass (OAGB) as a revisional option for failed restrictive procedures. In addition, we compare the outcomes of OAGB versus Roux-en-Y gastric bypass as a revisional bariatric procedures. Material and Methods: The current series is a prospective study, from May 2009 to December 2016. A total of 348 patients with failed restrictive bariatric operations underwent laparoscopic revisional gastric bypass. Revisional OAGB was performed in 243 patients and revisional Roux-en-Y gastric bypass in 105 patients. The demographic data and outcomes were studied by our multidisciplinary team. Result: By the end of the study, the mean age was 39.3 ± 10.3 years with body mass index of 37.5 ± 9.2 kg/m2. At 2-year follow-up, the overall intractable reflux (Symptom-Severity score questionnaire >4) was significantly higher after revisional OAGB (21.4%). The reflux with scoring ≥4 was significantly higher in the vertical band gastroplasty than laparoscopic adjustable gastric band and laparoscopic gastric sleeve (25.2%, 16.9%, and 14.3%, respectively). Conclusion: Although laparoscopic revisional OAGB is a feasible and safe option after failed restrictive procedures, it has a higher chance of reflux in long-term follow-up.

Roux-en-Y anastomosis

Adjustable gastric band

Upper endoscopy

Sleeve gastrectomy

10.1089/bari.2020.0106

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Staple Line Complications without Reinforcement, with Oversewing and with Buttressing Using Oxidized Regenerated Cellulose in Laparoscopic Sleeve Gastrectomy, Randomized Comparative Study

Bariatric Surgical Practice and Patient Care (2021)

Osama Taha Samia Saied Mohamed Shoeib Mahmoud Abdelaal Mohamed Abozeid

Background: Laparoscopic sleeve gastrectomy (LSG) is currently one of the most commonly performed bariatric procedures. Oversewing is one of most commonly performed techniques for staple line reinforcement. Oxidized regenerated cellulose (ORC) is an effective hemostatic agent with several advantages. This study aims to compare the outcomes of no-reinforcement, staple line oversewing and staple line buttressing with ORC in LSG. Materials and Methods: Patients were randomized into three groups: 100 patients underwent LSG without reinforcement, 100 patients underwent LSG with oversewing of the staple line, and 100 patients underwent LSG with staple line buttressing by using ORC. Results: The mean operative time was longer in patients with staple line oversewing; Group B (53.4 ± 4.21 min) compared with no reinforcement and using the ORC over the staple line (p-value <0.01). The postoperative bleeding is significantly (p < 0.05) reduced with oversewing and with using ORC compared with the control group. Conclusion: Oversewing of the staple line during LSG is a nonexpansive and easy method to decrease bleeding. However, it is time-consuming, associated with a higher incidence of staple line hematoma and postoperative vomiting. Using ORC is effective in reducing staple line bleeding in LSG compared with the control group.

10.1089/bari.2021.0033

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Lamivudine: An antiviral drug with high risk factor for selection of resistance in HBV patients

Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences (2021)

Mahmoud Abdelaal

Globally, it has been reported that nearly 257 million people suffer from chronic Hepatitis B virus (HBV). In Egypt, HBV has been classified as a moderate endemic where 4% of the population presented with chronic HBV. Long term Lamivudine (LMV) monotherapy has been found to develop resistant strains of HBV where the polymerase gene specifically is mutated (i.e., YMDD as a primary mutation). This review aimed to determine the correlation between LMV therapy and development of resistance in chronic HBV patients and to investigate the genes responsible for LMV resistance. LMV as an antiviral therapy has a fair response rate in the studied patients with 20% of the population has significant signs of mutation according to previous studies in Egypt . Unfortunately, the long duration treatment with LMV leads to development of LMV resistant mutations altering the efficacy of the drug and a rescue drug must be used immediately. Keywords: HBV, LMV, YMDD, Mutation, Resistance.

Antiviral drug

10.21608/rpbs.2021.83271.1106

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