Marisol Días

University of Minho

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Lorenzo Pastrana

International Iberian Nanotechnology Laboratory

Guillermo Quindós

University of the Basque Country

Sanna Sillankorva

International Iberian Nanotechnology Laboratory

Ana Mafalda Pinto

International Iberian Nanotechnology Laboratory

Miguel A. Cerqueira

International Iberian Nanotechnology Laboratory

Tony Collins

University of Minho

Paula Sampaio

University of Minho

Elena Eraso

University of the Basque Country

Augusto Costa‐Barbosa

University of Minho

Cristina Marcos‐Arias

University of the Basque Country

Cooperative Institutions

University of Minho

Indian Institute of Engineering Science and Technology, Shibpur

Indian Institute of Technology Kharagpur

National Institute of Technology Rourkela

Indian Institute of Technology Hyderabad

Clinical Academic Center of Braga

National University of Malaysia

Consejo Superior de Investigaciones Científicas

University of Madras

Tezpur University

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Vulvovaginal candidiasis and asymptomatic vaginal colonization in Portugal: Epidemiology, risk factors and antifungal pattern

Medical Mycology (2022)

Ângela Fernandes Nuno F. Azevedo Andreia Valente Marisol Días Ana Julia Pereira Santinho Gomes

Vulvovaginal candidiasis (VVC) has been identified as a global issue of concern due to its clinical, social and economic implications. The emerging relevance of VVC makes it crucial to increase the knowledge on its epidemiological and etiological features in order to improve its prevention and treatment. Thus, this study aimed to reveal the incidence, microbiology, antifungal pattern and risk factors of VVC in Portugal. For that, high vaginal samples were collected from 470 symptomatic and asymptomatic participants; Candida spp. were identified with molecular techniques and their antifungal susceptibility was analyzed with E-tests. The results revealed an incidence of VVC among women with vulvovaginitis of 74.4%. Furthermore, 63.7% of asymptomatic women were colonized with Candida spp. Importantly, women with history of recurrent vaginal infections, those who use over-the-counter antifungals, oral contraceptive pills and non-cotton underwear were found to be at significantly higher risk of developing VVC. Candida albicans was the most common species (59%), followed by Candida glabrata (27%), in a total of eight distinct species, with similar distribution among colonized and infected participants. Of note, various isolates, especially of the most common species, showed low susceptibility towards fluconazole. In contrast, only few isolates showed low susceptibility towards caspofungin. Overall, this study suggests that the identification of species causing VVC and their antifungal susceptibility are urgently needed in clinical practice in order to improve the decision for the most adequate treatment. It also suggests that avoiding certain risk behaviors may prevent the development of VVC.Vaginal candidiasis (VVC) is a relevant infection worldwide. In this study, we identified several risk behaviors that may promote VVC and concluded that vaginal microbiologic analyses are urgently required in clinical practice in order to improve the prevention and treatment of this disease.

Vulvovaginal Candidiasis

10.1093/mmy/myac029

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Digital Era: The Profile of the Quality Leader

2021 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM) (2023)

Pedro Domingues André Roncon Dias Marisol Días André M. Carvalho Paulo Sampaio

The purpose of this paper (of exploratory nature) is twofold. On one hand, this paper intends to report the soundest set of skills (dimensions) that comprise the desirable profile of the quality leader in the digital transition era. Additionally, the paper seeks to present a structural model (and all the development process to reach that model) identifying the statistically significant relationships between those dimensions, and their impact on each other and to point out some strategies that companies may adopt to update the skills of their human resources to successfully face the issues brought by Industry 4.0. Seven major sets of skills comprise the profile of the quality leader: leadership, adaptability, quality-oriented skills, personality traits, communicational skills, analytical skills, and technological skills. Leadership was the dimension identified as the more relevant to the profile of the quality leader 4.0.

Adaptability

Personality profile

10.1109/ieem58616.2023.10406442

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List of contributors

Elsevier eBooks (2023)

Richa Aggrawal Memoona Akhtar Kumar Anupam Mahreen Arooj Ahu Arslan Yıldız

10.1016/b978-0-323-88524-9.00035-8

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Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes

Applied Sciences (2022)

Marisol Días Marina Romaní‐Pérez Aloia Romaní Aimara de la Cruz Lorenzo Pastrana

Background: Phenolic compounds are food-derived bioactive compounds well-known for their antioxidant and anti-inflammatory properties. They are in the spotlight for the management of diabetes due to their positive effects on glucose homeostasis. Materials and methods: We have performed a literature review on the main topics related to the application of phenolic compounds as functional food ingredients. This includes extraction and purification from vegetable sources and agro-industrial by-products, encapsulation to improve their solubility and bioavailability, and preclinical and clinical evidence linking these compounds with anti-diabetic activity. Objectives: (1) provide an understanding of the role of phenolic compounds on diabetes; (2) identify green technologies for phenolic compounds extraction from agri-food by-products following a biorefinery scheme; (3) underline the relevance of encapsulation techniques using nanotechnology to improve their bioavailability; (4) discuss the therapeutic efficacy of polyphenols. Results: This review compiles recent relevant research on phenolic compounds extraction from renewable resources, their purification from agri-food by-products, and encapsulation strategies using eco-friendly processes. It also highlights the preclinical and clinical evidence on phenolic compounds’ antidiabetic activity, giving insight into their mechanisms of action. Conclusions: This review explores the latest advances in polyphenols and how their benefits in glucose homeostasis can be applied toward improving the health of patients with diabetes and related conditions.

Nutraceutical

10.3390/app12189271

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Natural biopolymer scaffolds for bacteriophage delivery in the medical field

Elsevier eBooks (2023)

Ana Mafalda Pinto Marisol Días Lorenzo Pastrana Miguel A. Cerqueira Sanna Sillankorva

Phage therapy

Biopolymer

Site of action

10.1016/b978-0-323-88524-9.00019-x

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Development and Characterization of Monoolein-Based Liposomes of Carvacrol, Cinnamaldehyde, Citral, or Thymol with Anti- Candida Activities

Antimicrobial Agents and Chemotherapy (2021)

Katherine Miranda-Cadena Marisol Días Augusto Costa‐Barbosa Tony Collins Cristina Marcos‐Arias

There is an increasing need for novel drugs and new strategies for the therapy of invasive candidiasis. This study aimed to develop and characterize liposome-based nanoparticles of carvacrol, cinnamaldehyde, citral, and thymol with anti-Candida activities. Dioctadecyldimethylammonium bromide- and monoolein-based liposomes in a 1:2 molar ratio were prepared using a lipid-film hydration method. Liposomes were assembled with equal volumes of liposomal stock dispersion and stock solutions of carvacrol, cinnamaldehyde, citral, or thymol in dimethyl sulfoxide. Cytotoxicity was tested on RAW 264.7 macrophages. In vitro antifungal activity of liposomes with phytocompounds was evaluated according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) methodology using clinical isolates of Candida albicans, Candida auris, Candida dubliniensis, and Candida tropicalis Finally, the ability of macrophage cells to kill Candida isolates after addition of phytocompounds and their nanoparticles was determined. Nanoparticles with 64 μg/ml of cinnamaldehyde, 256 μg/ml of citral, and 128 μg/ml of thymol had the best characteristics among the formulations tested. The highest encapsulation efficiencies were achieved with citral (78% to 83%) and carvacrol (66% to 71%) liposomes. Carvacrol and thymol in liposome-based nanoparticles were nontoxic regardless of the concentration. Moreover, carvacrol and thymol maintained their antifungal activity after encapsulation, and there was a significant reduction (∼41%) of yeast survival when macrophages were incubated with carvacrol or thymol liposomes. In conclusion, carvacrol and thymol liposomes possess high stability, low cytotoxicity, and antifungal activity that act synergistically with macrophages.

Carvacrol

Citral

Thymol

10.1128/aac.01628-20

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Erratum for Miranda-Cadena et al., “Development and Characterization of Monoolein-Based Liposomes of Carvacrol, Cinnamaldehyde, Citral, or Thymol with Anti- Candida Activities”

Antimicrobial Agents and Chemotherapy (2021)

Katherine Miranda-Cadena Marisol Días Augusto Costa‐Barbosa Tony Collins Cristina Marcos‐Arias

incorrect files were used for Fig. 6 to 10.In addition, "P , 0.5" should be "P , 0.05" in the legends of Fig. 7, 8, and 10, and in the 5th paragraph of the Results section, "64" in the 2nd-to-last sentence should be "32" and "P , 0.5" in the last sentence should be "P , 0.05.

Carvacrol

Thymol

Citral

Paragraph

10.1128/aac.00800-21

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Contribution of Nucleotide-Binding Oligomerization Domain-like (NOD) Receptors to the Immune and Metabolic Health

Biomedicines (2024)

César Jeri Apaza Marisol Días Aurora García-Tejedor Lisardo Boscá José Moisés Laparra

Nucleotide-binding oligomerization domain-like (NOD) receptors rely on the interface between immunity and metabolism. Dietary factors constitute critical players in the activation of innate immunity and modulation of the gut microbiota. The latter have been involved in worsening or improving the control and promotion of diseases such as obesity, type 2 diabetes, metabolic syndrome, diseases known as non-communicable metabolic diseases (NCDs), and the risk of developing cancer. Intracellular NODs play key coordinated actions with innate immune ‘Toll-like’ receptors leading to a diverse array of gene expressions that initiate inflammatory and immune responses. There has been an improvement in the understanding of the molecular and genetic implications of these receptors in, among others, such aspects as resting energy expenditure, insulin resistance, and cell proliferation. Genetic factors and polymorphisms of the receptors are determinants of the risk and severity of NCDs and cancer, and it is conceivable that dietary factors may have significant differential consequences depending on them. Host factors are difficult to influence, while environmental factors are predominant and approachable with a preventive and/or therapeutic intention in obesity, T2D, and cancer. However, beyond the recognition of the activation of NODs by peptidoglycan as its prototypical agonist, the underlying molecular response(s) and its consequences on these diseases remain ill-defined. Metabolic (re)programming is a hallmark of NCDs and cancer in which nutritional strategies might play a key role in preventing the unprecedented expansion of these diseases. A better understanding of the participation and effects of immunonutritional dietary ingredients can boost integrative knowledge fostering interdisciplinary science between nutritional precision and personalized medicine against cancer. This review summarizes the current evidence concerning the relationship(s) and consequences of NODs on immune and metabolic health.

10.3390/biomedicines12020341

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Optimization of the liposomal system of DODAB:MO: development of a vaccine against systemic infections caused by Candida albicans

Marisol Días

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