Roberto Menéndez

Cuban Neuroscience Center

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Rosa Más

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

Idania Rodeiro

Institut de Ciències del Mar

Rosa María Dasí González

UNESCO

Sònia Jiménez

Hospital Clínic de Barcelona

Erik L. Regalado

Merck & Co., Inc., Rahway, NJ, USA (United States)

Yohani Pérez

Centro Nacional de Investigaciones Científicas

Ruth A. Morales

Centro Nacional de Biopreparados (Cuba)

Julio César Fernández

Cuban Neuroscience Center

Miguel D. Fernández

Institut de Ciències del Mar

Rafael Gámez

Cuban Neuroscience Center

Cooperative Institutions

Cuban Neuroscience Center

Centro Nacional de Investigaciones Científicas

University of Havana

Centro Nacional de Biopreparados (Cuba)

Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear

Centro de Investigación y Desarrollo de medicamentos

Center of Molecular Immunology (Cuba)

ORCID

Universidad Nacional Autónoma de México

Universidade Católica de Pelotas

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Amylovis-201 enhances physiological memory formation and rescues memory and hippocampal cell loss in a streptozotocin-induced Alzheimer's disease animal model

Brain Research (2024)

Daymara Mercerón‐Martínez Luis-Giraldo Gonzalez Ricardo Arturo Bejerano Pina N. Rojo A. Seco

Memory Impairment

10.1016/j.brainres.2024.148848

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Citations (2)

Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia

Brazilian Journal of Medical and Biological Research (2000)

M.L. Arruzazabala M Noa Roberto Menéndez Rosa Más Daisy Carbajal

Policosanol is a mixture of higher aliphatic alcohols purified from sugar cane wax, with cholesterol-lowering effects demonstrable in experimental models and in patients with type II hypercholesterolemia. The protective effects of policosanol on atherosclerotic lesions experimentally induced by lipofundin in rabbits and rats and spontaneously developed in stumptail monkeys have been described. The present study was conducted to determine whether policosanol administered orally to rabbits with exogenous hypercholesterolemia also protects against the development of atherosclerotic lesions. Male New Zealand rabbits weighing 1.5 to 2 kg were randomly divided into three experimental groups which received 25 or 200 mg/kg policosanol (N = 7) orally for 60 days with acacia gum as vehicle or acacia gum alone (control group, N = 9). All animals received a cholesterol-rich diet (0.5%) during the entire period. Control animals developed marked hypercholesterolemia, macroscopic lesions and arterial intimal thickening. Intima thickness was significantly less (32.5 +/- 7 and 25.4 +/- 4 microm) in hypercholesterolemic rabbits treated with policosanol than in controls (57.6 +/- 9 microm). In most policosanol-treated animals, atherosclerotic lesions were not present, and in others, thickness of fatty streaks had less foam cell layers than in controls. We conclude that policosanol has a protective effect on the atherosclerotic lesions occurring in this experimental model.

Gum acacia

Cholesterol-lowering

10.1590/s0100-879x2000000700015

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Citations (41)

Phytochemical Analysis and Antioxidant Capacity of BM-21, a Bioactive Extract Rich in Polyphenolic Metabolites from the Sea Grass Thalassia testudinum

Natural Product Communications (2012)

Erik L. Regalado Roberto Menéndez Olga Valdés Ruth A. Morales Abilio Laguna

The aqueous ethanol extract of Thalassia testudinum leaves (BM-21) is now being developed in Cuba as an herbal medicine due to its promising pharmacological properties. Although some interesting biological activities of BM-21 have already been reported, its chemical composition remains mostly unknown. Thus, we now describe the qualitative and quantitative analyzes of BM-21 using standard phytochemical screening techniques, including colorimetric quantification, TLC and HPLC analyses. Phytochemical investigation of BM-21 resulted in the isolation and identification of a new phenolic sulfate ester (1), along with ten previously described phenolic derivatives (2-11), seven of which have never been previously reported from the genus Thalassia. The structures of these compounds were established by analysis of their spectroscopic (1D and 2D NMR) and spectrometric (HRMS) data, as well as by comparison of these with those reported in the literature. Furthermore, BM-21 was found to exhibit strong antioxidant activity in four different free radical scavenging assays (HO*, RO2*, O2-* and DPPH*). Consequently, this is the first study which highlights the phytochemical composition of BM-21 and demonstrates that this product is a rich source of natural antioxidants with potential applications in pharmaceutical, cosmetic and food industries.

Phytochemical

10.1177/1934578x1200700117

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Citations (18)

Inhibition of low-density lipoprotein (LDL) lipid peroxidation by policosanol, a new cholesterol-lowering agent

Atherosclerosis (2000)

Roberto Menéndez Rosa Más A.M. Amor Ricardo Miranda‐González Julio César Fernández

Low-density lipoprotein

10.1016/s0021-9150(00)80242-7

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Preclinical Oral Toxicology in Rats of D-002, a Natural Drug with Antiulcer Effects

Drug and Chemical Toxicology (1998)

Idania Rodeiro Celia Alemán M Noa Roberto Menéndez Rosa Más

D-002 is a mixture of higher aliphatic primary alcohol isolated from bees wax (Apis mellifera) with effective antiulcer effects demonstrated in different experimental models. Oral toxicity of D-002 (5-5000 mg/kg) was evaluated in sub-acute (14 days), subchronic (90 days) and chronic (1 year) studies in Sprague-Dawley rats from both sexes. There was no treatment-related toxicity. Thus, effects on body weight, food consumption, clinical observations, blood parameters, organ weight ratios and histopathological findings were similar in control and treated groups. These short and long-term studies support a wide safety margin for this product.

Antiulcer drug

Chronic toxicity

10.3109/01480549809011644

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Citations (20)

P-440: Effectiveness of a specific multidimensional intervention program in 509 hip fracture patients. Results at 3 and 6 months after discharge

European Geriatric Medicine (2015)

Roberto Menéndez Teresa Alarcón Juan Ignacio González-Montalvo Á. Otero Rocío Queipó

Coagulase

Subclinical infection

10.1016/s1878-7649(15)30537-4

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A comparative pharmacokinetic and pharmacodynamic study of two novel Cuban PEGylated rHuEPO versus MIRCERA® and ior®EPOCIM.

Gledys Reynaldo Leyanis Rodríguez‐Vera Roberto Menéndez Joaquín Solazábal Daniel Amaro

: La eritropoyetina humana recombinante (rHuEPO) estimula la formacion de eritrocitos en la medula osea. Esta glicoproteina terapeutica presenta rapida eliminacion en el organismo. Una de las estrategias tecnologicas para resolver esta problematica es la PEGgilacion. Objetivos: Evaluar la farmacocinetica y la farmacodinamica de dos nuevas eritropoyetinas PEGiladas ramificadas (una asimetrica de 32 kDa-PEG2- rHuEPO y otra simetrica de 40 kDa-PEG2-rHuEPO) en comparacion con ior®EPOCIM y el producto de referencia MIRCERA®. Metodos: Se midieron las concentraciones sericas de eritropoyetina PEGilada y no PEGilada, a diferentes tiempos, para determinar los parametros farmacocineticos usando el metodo de analisis no compartimental. Se determinaron los % de reticulocitos, los niveles de eritrocitos y hemoglobina para comparar el efecto de estas moleculas despues de administrar a dosis unica 10 μg/kg por via intravenosa en conejos Nueva Zelanda machos. Resultados: Las eritropoyetinas PEGiladas ramificadas presentaron semividas significativamente superiores a ior®EPOCIM (p<0,05), pero no fueron estadisticamente diferentes a MIRCERA®. El t1/2 aumento de 4 h (ior®EPOCIM) a 131 h para la 32 kDa-PEG2-rHuEPO y 119 h para la 40 kDaPEG2-rHuEPO, respectivamente. Ambas eritropoyetinas PEGiladas mejoraron significativamente el efecto estimulante sobre la formacion de reticulocitos y eritrocitos, asi como los niveles de hemoglobina, en comparacion con ior®EPOCIM hasta 42 dias despues de la dosis. Conclusiones: La estrategia de PEGilacion, empleada en este estudio, es un metodo efectivo para modificar la farmacocinetica y farmacodinamia de moleculas de eritropoyetinas. Esta tecnologia permitio aumentar la semivida de estas moleculas, asi como prolongar su bioactividad in vivo. Ambas formas ramificadas de rHuEPO PEGiladas son candidatos prometedores para su uso clinico

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Citations (1)

Corrigendum to “JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats” [Neurotoxicology 87 (2021) 70–85]

NeuroToxicology (2023)

Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ramírez-Sánchez Javier Jiménez-Martín Luis Arturo Fonseca-Fonseca

Memory Impairment

Neuronal damage

10.1016/j.neuro.2023.09.003

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In vitro effect of D-004, a lipid extract from the fruits of Cuban royal palm, on androgenic receptors of prostatic tissue

Revista CENIC. Ciencias Biológicas (2007)

Yohani Pérez Roberto Menéndez Rosa Más Rosa María Dasí González

Resumen es: La hiperplasia prostatica benigna (HPB) consiste en el crecimiento incontrolado y benigno de los elementos estromales y glandulares de la prostata, que d...

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Thalassia testudinum, a sea plant with great therapeutical potentialities

Revista cubana de plantas medicinales (2012)

Eliane de la Torre Núñez Idania Rodeiro Roberto Menéndez Dalmis Pérez Carrasco

Thalassia testudinum

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Citations (2)