Michael R. Jackson

Royal Hospital for Children

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Per A. Peterson

Instytut Farmaceutyczny

Anders Brunmark

Johnson & Johnson (United States)

P A Peterson

Springhouse

R.M. Parkin

Loughborough University

Laura Justham

Loughborough University

Luc Teyton

Scripps Research Institute

Zeling Cai

Shanghai CASB Biotechnology (China)

Niels Lohse

Loughborough University

Ze’ev A. Ronai

Sanford Burnham Prebys Medical Discovery Institute

Brian Burchell

University of Dundee

Cooperative Institutions

Sanford Burnham Prebys Medical Discovery Institute

Discovery Institute

General Atomics (United States)

Loughborough University

Scripps Research Institute

Massachusetts Institute of Technology

Lawrence Livermore National Laboratory

Los Alamos National Laboratory

University of Rochester

University of California, San Diego

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Mechatronic approach towards surface quality improvement in rotary wood machining

Proceedings of the Institution of Mechanical Engineers Part B Journal of Engineering Manufacture (2013)

Philips S. Ogun Michael R. Jackson Robert Parkin

The primary causes of defects in planed timber surfaces have been identified to be cutting tool inaccuracy and forced vibration during the machining process. It is noted that the current mechanical methods used in the woodworking industry to improve surface finish quality have disadvantages that defeat their original attractiveness. This article describes a mechatronic approach used to compensate for cutting tool inaccuracy in wood planing via cutting tool trajectory modification. The approach is based on real-time measurement of the angular spindle position, coupled with periodic vertical displacements of the rotating spindle. A small-scale wood planing machine, which has an actively controlled spindle unit, has been designed for practical investigation of the technique. Experimental results show that the dynamic performance of wood planing machines, and hence the surface finish quality, can be improved via this approach.

Machine tool

Woodworking

Position (finance)

10.1177/0954405412461742

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Citations (2)

Visualization methods for understanding the dynamic electroadhesion phenomenon

Journal of Physics D Applied Physics (2017)

Thomas Bamber Jianglong Guo Jaskaran Singh Masoud Bigharaz Jon N. Petzing

Experimental investigation into the surface potential and electric field visualization of an electroadhesion system is presented for understanding the dynamic electroadhesion phenomenon. The indirect experimental approach has been based on measuring surface potentials on the surface of an electroadhesive pad by an electrostatic voltmeter. The direct approach has been based on charging and discharging the electroadhesive pad in a viscous oil mixed with lightweight particles. The visualization of the dynamic field distribution of electroadhesive pads can be a useful method to understand the dynamic electroadhesion phenomenon. In addition, indication of different field distributions of different pad geometries can be obtained through the method demonstrated here. Furthermore, the method is useful for instructors or lecturers to showcase or teach the dynamic electroadhesion phenomenon.

Phenomenon

10.1088/1361-6463/aa6be4

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Citations (33)

Experimental study of a flexible and environmentally stable electroadhesive device

Applied Physics Letters (2017)

Jianglong Guo Thomas Bamber Jaskaran Singh David Manby Paul A. Bingham

Electroadhesion is a promising adhesion mechanism for robotics and material handling applications due to several distinctive advantages it has over existing technologies. These advantages include enhanced adaptability, gentle/flexible handling, reduced complexity, and ultra-low energy consumption. Unstable electroadhesive forces, however, can arise in ambient environments. Electroadhesive devices that can produce stable forces in changing environments are thus desirable. In this study, a flexible and environmentally stable electroadhesive device was designed and manufactured by conformally coating a layer of barium titanate dielectric on a chemically etched thin copper laminate. The results, obtained from an advanced electroadhesive “normal force” testing platform, show that only a relative difference of 5.94% in the normal force direction was observed. This was achieved when the relative humidity changed from 25% to 53%, temperature from 13.7 °C to 32.8 °C, and atmospheric pressure from 999 hPa to 1016.9 hPa. This environmentally stable electroadhesive device may promote the application of the electroadhesion technology.

Adaptability

Environmentally Friendly

Barium titanate

10.1063/1.4995458

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Citations (14)

Investigation of relationship between interfacial electroadhesive force and surface texture

Journal of Physics D Applied Physics (2015)

Jianglong Guo Mitul Tailor Thomas Bamber Michael J. Chamberlain Laura Justham

A novel investigation into the relationship between the obtainable interfacial electroadhesive forces and different surface textures is presented in this paper. Different surface textures were generated then characterized based on a recognized areal-based non-contact surface texture measurement platform and procedure. An advanced electroadhesive force measurement platform and procedure were then implemented to measure the obtainable electroadhesive forces on those different surface textures. The results show that the obtained interfacial electroadhesive forces increase with decreasing Sq (root mean square height) value of the substrate surface provided that the difference in Sq between the different substrates is over 5 μm. Also, the higher the applied voltage, the larger the relative increase in electroadhesive forces observed. However, when the difference of Sq value between different substrate surfaces is below 2 μm, the obtained interfacial electroadhesive forces do not necessarily increase with decreasing Sq. Furthermore, the obtainable electroadhesive forces are not necessarily the same when the Sq value of two substrate surfaces are the same due to the fact that the direction of the surface texture plays an important role in achieving electroadhesive forces.

Texture (cosmology)

Surface force

Root mean square

Value (mathematics)

10.1088/0022-3727/49/3/035303

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Citations (52)

Transmissive dark-field illumination method for high-accuracy automatic lace scalloping

The International Journal of Advanced Manufacturing Technology (2006)

P E Bamforth Michael R. Jackson K. Williams

10.1007/s00170-005-0359-4

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Citations (6)

Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells

The Journal of Experimental Medicine (1997)

Zeling Cai Hidehiro Kishimoto Anders Brunmark Michael R. Jackson Per A. Peterson

The requirements for inducing downregulation of α/β T cell receptor (TCR) molecules on naive major histocompatibility complex class I–restricted T cells was investigated with 2C TCR transgenic mice and defined peptides as antigen. Confirming previous results, activation of 2C T cells in response to specific peptides required CD8 expression on the responder cells and was heavily dependent upon costimulation provided by either B7-1 or ICAM-1 on antigen-presenting cells (APC). These stringent requirements did not apply to TCR downregulation. Thus, TCR downregulation seemed to depend solely on TCR/peptide/interaction and did not require either CD8 or B7-1 expression; ICAM-1 potentiated TCR downregulation, but only with limiting doses of peptides. TCR downregulation was most prominent with high affinity peptides and appeared to be neither obligatory nor sufficient for T cell activation. In marked contrast to T cell activation, TCR downregulation was resistant to various metabolic inhibitors. The biological significance of TCR downregulation is unclear, but could be a device for protecting T cells against excessive signaling.

10.1084/jem.185.4.641

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Citations (170)

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Bioorganic & Medicinal Chemistry Letters (2017)

Anthony B. Pinkerton Eduard Sergienko Yalda Bravo Russell Dahl Chen-Ting Ma

10.1016/j.bmcl.2017.11.024

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Citations (35)

Using laser capture microdissection (LCM) to build cDNA microarray expression databases with cell-type specificity

Nature Genetics (1999)

Mark G. Erlander Jackson Wan Michael R. Jackson

Laser capture microdissection

Microdissection

10.1038/14302

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Citations (0)

Peptide-independent Recognition by Alloreactive Cytotoxic T Lymphocytes (CTL)

The Journal of Experimental Medicine (1997)

Pam Smith Anders Brunmark Michael R. Jackson Terry A. Potter

We have isolated several H-2Kb–alloreactive cytotoxic T cell clones and analyzed their reactivity for several forms of H-2Kb. These cytotoxic T lymphocytes (CTL) were elicited by priming with a skin graft followed by in vitro stimulation using stimulator cells that express an H-2Kb molecule unable to bind CD8. In contrast to most alloreactive T cells, these CTL were able to recognize H-2Kb on the surface of the antigen processing defective cell lines RMA-S and T2. Furthermore, this reactivity was not increased by the addition of an extract containing peptides from C57BL/6 (H-2b) spleen cells, nor was the reactivity decreased by treating the target cells with acid to remove peptides bound to MHC molecules. The CTL were also capable of recognizing targets expressing the mutant H-2Kbm8 molecule. These findings suggested that the clones recognized determinants on H-2Kb that were independent of peptide. Further evidence for this hypothesis was provided by experiments in which H-2Kb produced in Drosophila melanogaster cells and immobilized on the surface of a tissue culture plate was able to stimulate hybridomas derived from these alloreactive T cells. Precursor frequency analysis demonstrated that skin graft priming, whether with skin expressing the wild-type or the mutant H-2Kb molecule, is a strong stimulus to elicit peptide-independent CTL. Moreover, reconstitution experiments demonstrated that the peptide-independent CTL clones were capable of mediating rapid and complete rejection of H-2–incompatible skin grafts. These findings provide evidence that not all allorecognition is peptide dependent.

CTL*

Priming (agriculture)

10.1084/jem.185.6.1023

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Citations (110)

Immune-Associated Nucleotide-1 (IAN-1) Is a Thymic Selection Marker and Defines a Novel Gene Family Conserved in Plants

The Journal of Immunology (1999)

Ghislaine Poirier Graham Anderson Arne Huvar Pamela C. Wagaman John Shuttleworth

Positive selection of thymocytes is a complex and crucial event in T cell development that is characterized by cell death rescue, commitment toward the helper or cytotoxic lineage, and functional maturation of thymocytes bearing an appropriate TCR. To search for novel genes involved in this process, we compared gene expression patterns in positively selected thymocytes and their immediate progenitors in mice using the differential display technique. This approach lead to the identification of a novel gene, mIAN-1 (murine immune-associated nucleotide-1), that is switched on upon positive selection and predominantly expressed in the lymphoid system. We show that mIAN-1 encodes a 42-kDa protein sharing sequence homology with the pathogen-induced plant protein aig1 and that it defines a novel family of at least three putative GTP-binding proteins. Analysis of protein expression at various stages of thymocyte development links mIAN-1 to CD3-mediated selection events, suggesting that it represents a key player of thymocyte development and that it participates to peripheral specific immune responses. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals.

Thymocyte

Negative selection

Conserved sequence

Protein family

10.4049/jimmunol.163.9.4960

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Citations (64)