An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Objective
To analyze the clinical characteristics of Kawasaki disease shock syndrome (KDSS) and to improve the diagnosis, treatment and prognosis of patients.
Methods
A total of 924 cases of Kawasaki disease (KD) hospitalized from January 2013 to April 2017 in our hospital were retrospectively analyzed, including 16 children with KDSS.And 30 patients with KD were randomly selected as the control group.The clinical characteristics, laboratory examination and treatment of the two groups were compared and analyzed.
Results
There were 9 males and 7 females in KDSS group, and average age was (3.95±2.56) years.The average time to happen shock was (4.31±0.79) days.There were no significant differences in gender, age and duration of fever between KDSS group and KD group respectively (P>0.05). KDSS patients were more likely to develop abdominal pain, hepatic injury (including elevated transaminase and jaundice), proteinuria, peritoneal effusion, pneumonia, coronary aneurysm, IVIG resistance and longer hospitalization (P 0.05). The levels of platelet count[ (655.50±226.98)×109/L vs.(549.93±119.15)×109/L], the albumin (g/L) [(22.54±5.13) vs.(33.32±3.18)], serum sodium(mmol/L)[(130.47±2.79) vs.(134.77±2.81)] and serum potassium (mmol/L) [(4.59 ± 0.74) vs.(4.04 ± 0.43)] and ejection fraction [(60.16±6.18)% vs.(64.81±3.71)%] in KDSS group were lower than those in KD group (P<0.05). During the course of treatment, 14 patients were accepted fluid resuscitation and the average volume of fluid was (27.19 ± 19.58) ml/kg.Ten patients used vasoactive drugs.Six patients were treated with hormone (methylprednisolone). All patients were discharged from hospital.
Conclusion
KDSS is a serious form of KD, the indicators of inflammatory response increased more obviously.Organ damage occurs more frequently, and often accompanies abdominal pain.Anti-shock treatment often requires fluid resuscitation and use of vasoactive drugs.
Key words:
Kawasaki disease; Kawasaki disease shock syndrome; Shock; Children
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
A local time-stepping procedure for the space-time conservation element and solution element (CESE) method has been developed. This new procedure allows for variation of time-step size in both space and time, and can also be extended to become multi-dimensional solvers with structured/unstructured spatial grids. Moreover, it differs substantially in concept and methodology from the existing approaches. By taking full advantage of key concepts of the CESE method, in a simple and efficient manner it can enforce flux conservation across an interface separating grid zones of different time-step sizes. In particular, no correction pass is needed. Numerical experiments show that, for a variety of flow problems involving moving shock and flame discontinuities, accurate and robust numerical simulations can be achieved even with a reduction in time-step size on the order of 10 or higher for grids across a single interface.
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