Lifeng Wang

XinHua Hospital

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Yan Zhang

Hebei Food Inspection and Research Institute

Wenjing Zhao

Harvard University

Yuxiang Wang

Fudan University

Heping Zhang

Yale University

Lele Zhao

Anhui Medical University

Zhengxiao Zhai

Shanghai Jiao Tong University

Li Leng

Education Department of Heilongjiang Province

Jinmei Ding

Shanghai Jiao Tong University

Chuan He

Wuhan University

He Meng

Shanghai Jiao Tong University

Cooperative Institutions

Shanghai Jiao Tong University

ShanghaiTech University

XinHua Hospital

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

Northeast Agricultural University

Nanjing University

Anhui Medical University

Fudan University Shanghai Cancer Center

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MOESM1 of Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota

Figshare (2016)

Jinmei Ding Lele Zhao Lifeng Wang Wenjing Zhao Zhengxiao Zhai

Additional file 1: Table S1. Summary of sequencing data for all samples.

10.6084/m9.figshare.c.3635027_d8

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Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma

iScience (2023)

Chuanxu Liu Xinyu Ding Gaoyang Li Youping Zhang Yubao Shao

Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive lymphoid malignancy with a poor prognosis and lacks standard treatment. Targeted therapies are urgently needed. Here we systematically investigated the druggable mechanisms through chemogenomic screening and identified that Bcl-xL-specific BH3 mimetics effectively induced ENKTL cell apoptosis. Notably, the specific accumulation of Bcl-xL, but not other Bcl-2 family members, was verified in ENKTL cell lines and patient tissues. Furthermore, Bcl-xL high expression was shown to be closely associated with worse patient survival. The critical role of Bcl-xL in ENKTL cell survival was demonstrated utilizing selective inhibitors, genetic silencing, and a specific degrader. Additionally, the IL2-JAK1/3-STAT5 signaling was implicated in Bcl-xL dysregulation. In vivo, Bcl-xL inhibition reduced tumor burden, increased apoptosis, and prolonged survival in ENKTL cell line xenograft and patient-derived xenograft models. Our study indicates Bcl-xL as a promising therapeutic target for ENKTL, warranting monitoring in ongoing clinical trials by targeting Bcl-xL.

Bcl-xL

Venetoclax

Druggability

T-Cell Lymphoma

Bcl-2 Family

10.1016/j.isci.2023.107369

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MOESM6 of Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota

Figshare (2016)

Jinmei Ding Lele Zhao Lifeng Wang Wenjing Zhao Zhengxiao Zhai

Additional file 6: Table S5. Corresponding metabolic pathways of the significant functions in the heatmap (related to Fig.Â 4). This table lists the corresponding metabolic pathways that are in Fig.Â 4.

10.6084/m9.figshare.c.3635027_d4

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