Jiancheng Liao

First Affiliated Hospital of Jinan University

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Maoying Zhang

Shenyang Pharmaceutical University

Xiangyu Wang

Hebei Medical University

Jiaxuan Zhang

Huazhong University of Science and Technology

Gong Chen

Sun Yat-sen University Cancer Center

Weilong Ding

Hong Kong University of Science and Technology

Jason H. Huang

Baylor Scott & White Health

Menghui Li

Beijing Chao-Yang Hospital

Qingsong Wang

Peking University

Keen Chen

First Affiliated Hospital of Jinan University

Wei Li

Indiana University – Purdue University Indianapolis

Cooperative Institutions

First Affiliated Hospital of Jinan University

Jinan University

Chinese Academy of Sciences

Southern Medical University

Shanghai Jiao Tong University

Capital Medical University

Baylor Scott & White Medical Center - Temple

Baylor Scott & White Health

Guangzhou Medical University

Fudan University

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NeuroD1 and Ascl1 Convert Human Glial Cells into Neurons in Ex Vivo Culture of Human Brain Tissue

Research Square (Research Square) (2023)

Liang Xu Qingsong Wang Jiancheng Liao Jiajun Zheng Bing Qin

Abstract Transcription factor-mediated cell conversion has been reported in the central nervous system (CNS) of both rodents and non-human primates (NHPs). In particular, glia-to-neuron (GtN) conversion has been achieved in the brains and spinal cords of animal models of neurological disorders for neural regeneration and repair. However, whether GtN conversion can ultimately be used for human brain repair in patients is still unknown. To investigate the applicability of GtN conversion technology in the human brain, we established a long-term ex vivo culture system using human brain tissue that was surgically removed from epileptic patients to directly test GtN conversion. We demonstrate that both neural transcription factors NeuroD1 and Ascl1 can convert human glial cells into neurons. Importantly, both immunostaining and electrophysiological recordings revealed that the glia-converted neurons showed immature properties during the initial 1–2 weeks of conversion, and then acquired more mature neuronal properties after 3–4 weeks of conversion. These ex vivo conversion studies in human brain tissue pave the way toward future clinical trials using a transcription factor-based glia-to-neuron conversion approach to treat neurological disorders.

Ex vivo

Immunostaining

Human brain

10.21203/rs.3.rs-3697467/v1

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Early tracheostomy is associated with better prognosis in patients with brainstem hemorrhage

Journal of Integrative Neuroscience (2020)

Weilong Ding Yong-Sheng Xiang Jiancheng Liao Shiyong Wang Xiangyu Wang

Journals Journal of Men's Health Frontiers in Bioscience-Elite Frontiers in Bioscience-Scholar Frontiers in Bioscience-Landmark Journal of Integrative Neuroscience Reviews in Cardiovascular Medicine Journal of Molecular and Clinical Medicine European Journal of Gynaecological Oncology Clinical and Experimental Obstetrics & Gynecology Resources For Authors For Reviewers For Editors Article Processing Charges Open Access Editorial Policies Publishing Ethic Copyright & License Digital Archive Privacy Policy Advertising Policies Peer Review Policy About Overview Management Team Contact US Search Submit Home About Overview Aims & Scope Editorial Board Reviewer Board Indexing & Archiving Conferences Articles Forthcoming Issue Current Issue All Issues Special Issues Special Issues Edit a Special Issue For Authors Submit Instructions for Authors Article Processing Charge Editorial Process Editorial Office Article Article Special Issue Advanced Countries | Regions Countries | Regions Article Types Article Types Year — Volume Issue Pages — Search

Editorial board

Scope (computer science)

10.31083/j.jin.2020.03.25

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Citations (13)

Revision Surgery Technique in the Treatment of Refractory Subcutaneous Cerebrospinal Fluid Collection Combined with Intracranial Infection Following Posterior Fossa Surgery

Cureus (2020)

Weilong Ding Hua Chen Yongsheng Xiang Jiancheng Liao Xiaoming Qi

Objective Cerebrospinal fluid (CSF) leakage remains the most common and serious complication following posterior fossa surgery. Persistent subcutaneous CSF collections can cause wound dehiscence and predispose patients to intracranial infection. Management with conservative treatment fails in up to 40% of patients, and revision surgery remains the last resort. We hereby introduce a novel surgical technique using muscle graft or pedicled trapezius muscle flaps to repair dura and skull base defect for the treatment of subcutaneous CSF collections refractory to conservative management. Methods A retrospective chart review was conducted for six patients who presented to our institution from 2012 to 2020, with subcutaneous CSF collections following posterior fossa surgeries and had undergone revision surgeries after unsuccessful management with conservative treatments. Patient demographics, etiologies, culture results, revision procedures, follow-ups, and recurrences of fluid collections were collected. Results Of these six patients, two underwent repair of dura and skull base defect with pedicled trapezius muscle flaps, and four had arachnoid fistula repaired with autologous muscle graft. All six patients fully recovered. CSF leakage and subcutaneous fluid collections were resolved. No recurrences occurred upon the last follow-ups. Conclusion A revision surgery using muscle graft or pedicled trapezius muscle flaps to repair the dura and skull base defect is effective at treating persistent cerebrospinal fluid leakage and subcutaneous fluid collection refractory to conservative treatment.

Pseudomeningocele

Cerebrospinal fluid leak

10.7759/cureus.10610

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Citations (3)

Quantitative study on magnetic flux leakage internal detection signal of defects on the outer wall of bimetal composite pipes

International Journal of Pressure Vessels and Piping (2025)

Tengjiao He Huagui Zhong Kexi Liao Jiancheng Liao Shuai Zhao

Magnetic Flux Leakage

Bimetal

Leakage (economics)

SIGNAL (programming language)

10.1016/j.ijpvp.2025.105438

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Advances in the Diagnosis and Treatment of Sacral Cysts

International Journal of Biology and Life Sciences (2024)

Menghui Li Jiancheng Liao Liqun He Dongyue Li Maoying Zhang

Sacral cysts have become a neurological disease that has received widespread attention in recent years. Its etiology and pathogenesis are still unclear, and it is more commonly believed to be the result of the interaction of multiple factors, which leads to clinical symptoms such as chronic low back pain and dysfunction of urinary and fecal functions. The disease is detected and diagnosed by magnetic resonance imaging, and treatment options include conservative treatment, interventional therapy, and surgical removal. However, there is no consensus on the diagnosis and treatment of sacral cysts, which has led to stagnation in the diagnosis and treatment of this disease. This article summarizes the definition, epidemiological characteristics, etiology and pathogenesis, diagnosis and treatment of this disease, in order to provide certain reference for clinical work.

10.54097/b3krzn29

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A Mathematic Mobile Cloud Computing System

Lecture notes in computer science (2014)

Tyng‐Yeu Liang Youjie Li Ga-Jin He Jiancheng Liao

Shared resource

Mobile Cloud Computing

10.1007/978-3-319-11167-4_28

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Citations (1)

Cerebrospinal fluid leak management in anterior basal skull fractures secondary to head trauma

Neurological Research (2022)

Jiancheng Liao Buqing Liang Xiangyu Wang Jason H. Huang

To summarize the presentation, diagnosis, and management of cerebrospinal fluid (CSF) leaks in the setting of traumatic anterior skull base fracture.Wide literature research has been performed as well as the authors' own clinical experience has been summarized.Articles from the most recent 30 years have been reviewed and a typical case of our own has been presented. Based on the most updated evidence, a treatment algorithm for CSF leaks has been proposed.Anterior skull base fracture accounts for about 4% of all head injuries and CSF leaks is a complication that commonly presents with clear fluid emanating from the nasal passage. A positive beta-2-transferrin study is highly specific for diagnosis, while thin-slice CT scanning and MRI cisternography are also useful tools. The majority of the CSF leaks tend to be resolved spontaneously, and conservative management is attempted first with or without the augmentation of a lumbar drain. Surgical management mainly includes open surgery and endoscopic surgery, which have their own pros and cons.

Cerebrospinal fluid leak

Conservative Management

Skull fracture

Head trauma

Presentation (obstetrics)

10.1080/01616412.2022.2066783

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Citations (2)

Prognostic data analysis of surgical treatments for intracerebral hemorrhage

Neurosurgical Review (2022)

Yongjun Yi Wenqiang Che Yongfu Cao Fanfan Chen Jiancheng Liao

10.1007/s10143-022-01785-5

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Conversion of human glial cells into neurons in ex vivo culture of human brain tissue: essential roles of the transcription factors NeuroD1 and Ascl1

Neural Regeneration Research (2024)

Liang Xu Qingsong Wang Jiancheng Liao Jiajun Zheng Bing Qin

Transcription factor–mediated cell conversion has been reported in the central nervous system of both rodents and nonhuman primates. In particular, glia-to-neuron conversion has been achieved in the brain and spinal cord of animal models for neural regeneration and repair. However, whether glia-to-neuron conversion can be used for brain repair in humans needs to be explored. To investigate the use of glia-to-neuron conversion technology in the human brain, we established a long-term ex vivo culture system using human brain tissue that was surgically removed from epileptic patients to test glia-to-neuron conversion directly. We found that neural transcription factors NeuroD1 and Ascl1 both converted human glial cells into neurons. Immunostaining and electrophysiological recordings showed that the glia-converted neurons demonstrated immature properties during the initial 7–14 days of conversion, and then acquired more mature neuronal properties after 21–27 days of conversion. These ex vivo conversion studies in human brain tissue pave the way toward future clinical trials using a transcription factor-based glia-to-neuron conversion approach to treat neurological disorders.

Ex vivo

Immunostaining

10.4103/nrr.nrr-d-24-00883

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Surgical Treatment of Intracranial Solitary Fibroma Tumors

International Journal of Biology and Life Sciences (2022)

Jiancheng Liao Tingfeng Wu Menghui Li Lu Chen Keen Chen

Objective: To summarize the clinical presentation, diagnosis, and therapy of solitary fibrous tumors (SFT) individuals. Methods: Broad literature research has been conducted as well as the author’s own clinical experienced has been reviewed. Results: Articles from the most recent 30 years have been collected while a typical case of our own has been presented. Based on the most updated evidence, the therapy of SFT has been proposed. Conclusion: For intracranial SFT, it’s rare and similar to common intracranial tumors in imaging examination, the misdiagnosis rate is high. Total surgical resection and postoperative radiotherapy have a certain effect on the prognosis of patients, and gene sequencing can guide the pathological molecular typing of patients and the next step of treatment.

Presentation (obstetrics)

Surgical resection

Solitary Fibrous Tumor

10.54097/ijbls.v1i1.3792

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