On the basis of details of the three-dimensional structures of beta-D-glucose and of cytochalasins, either previously published or reported here (cytochalasin A), we propose a model to explain the observed difference in activity of cytochalasins in the inhibition of glucose transport. In our model cytochalasin B binds to the glucose carrier through hydrogen bonds at N2 (donates), O7 (accepts), and O23 (accepts) analogous to O6, O3, and O1, respectively, on beta-D-glucose. The hydrophobic region from C13 to C19 is also essential in binding and appears to act as an anchor in a hydrophobic domain of the glucose carrier. The presence of hydrophilic groups in this essential hydrophobic region accounts, at least in part, for the inactivity of the other cytochalasins in the series.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron population analysis of accurate diffraction data. II. Application of one-center formalisms to some organic and inorganic moleculesPhilip Coppens, D. Pautler, and J. F. GriffinCite this: J. Am. Chem. Soc. 1971, 93, 5, 1051–1058Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/ja00734a001https://doi.org/10.1021/ja00734a001research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract Diabetes: Your Complete Exercise Guide, N.F. Gordon, Human Kinetics, Champaign, IL, 1993. xiv+137 pp., £8.95 (pb), ISBN 0 87322 427 2 Intensive Participation in Children's Sports, B.R. Cahill and A.J. Pearl (eds), Human Kinetics, Champaign, IL, 1993. xiii + 240 pp., £33.00 (hb), ISBN 0 87322 409 4 British Medical Bulletin on Sports Medicine, Vol. 48 (Part 3), J.B. King (ed.), Churchill Livingstone, Edinburgh, 1992. iii + 239 pp., £33.00 (hb), ISBN 0 443 04719 7 Nutrition and Fitness for Athletes, A.P. Simopoulos and K.N. Pavlou (eds), Karger, Basel, 1993. xvi+200 pp., £148.00 (hb), ISBN 3 8055 5707 8 The Complete Guide to Sports Nutrition, A. Bean, A.&C. Black (Publishers) Ltd, London, 1993. iv+188 pp., £11.99 (pb), ISBN 0 7136 3605 X Post‐viral Fatigue Syndrome (Myalgic encephalitis), R. Jenkins and J. Mowbray (eds), John Wiley, Chichester, 1992. xxvii + 463 pp., £24.95 (pb), ISBN 0 471 93879 3 Proceedings of the 10th Cologne Workshop on Dope Analysis, M. Donike, H. Geyer, A. Gotymann, U. Mareck‐Engelke and S. Rauth (eds), Sport und Buch Straus, Cologne, 1993. 395 pp., DM45.00 (pb), 3 89001 0113 World‐wide Variation in Physical Fitness, A.L. Claessens, J. Lefevre and B.V. Eynde (eds), Leuven Institute of Physical Education, Leuven, 1993. 221 pp., $20.00 (pb) Learning Experiences in Sociology of Sport, L. Greendorfer and C.A. Hasbrook, Human Kinetics, Champaign, IL, 1990. viii+141 pp., $18.00 (pb), ISBN 0 87322 298 9 The Soft Tissues: Trauma and Sports Injuries, G.R. McLatchie and C.M.E. Lennox (eds), Butterworth‐Heinemann, Oxford, 1993. ix + 485 pp., £45.00 (hb), ISBN 0 7506 0170 1 Towards Active Living, H.R. Quinney, L. Gauvin and A.E.T. Wall (eds), Human Kinetics, Champaign, IL, 1994. xv + 294 pp., £31.50 (pb), ISBN 0 87322 523 6 Alpine Skiing, R.E. Leach (ed.), Blackwell Scientific, Oxford, 1994. vii+128 pp., £14.95 (pb), ISBN 0 632 03033 X
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of pseudoallylic strain on the conformational preference of 4-methyl-4-phenylpipecolic acid derivativesElizabeth E. Sugg, Jane F. Griffin, and Philip S. PortogheseCite this: J. Org. Chem. 1985, 50, 25, 5032–5037Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/jo00225a006https://doi.org/10.1021/jo00225a006research-articleACS PublicationsRequest reuse permissionsArticle Views361Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A case control study of 50 rheumatoid factor positive (RA+) and 50 rheumatoid factor negative (RA−) patients with rheumatoid arthritis has been carried out. As expected, the RA+ group has significantly more nodules and vasculitis. In terms of clinical joint involvement, the RA− had large-joint involvement. Radiologically, seropositive disease was characterized by more severe involvement of the metacarpophalangeal joints of the thumb and index fingers and in all the metatarsophalangeal joints of the feet. There was no difference either clinically or radiologically between the two groups in terms of symmetry of joint disease or wrist involvement. Of special interest was the finding that the prevalence of HLA-DR4 was elevated to the same degree in both groups but that genetic markers for ankylosing spondylitis and for psoriasis (HLA-B27 and Cw6 respectively) were similar in both groups and not increased above control population levels. It is concluded that the entity defined as RA includes patients with and without rheumatoid factor (RF) in their serum and that this determines differences in disease expression. Whether these differences are the consequences or the cause of RF cannot be concluded on the basis of this study.
Starvation results in a rapid and significant decrease in gulonolactone hydrolase activity in both males and females while gulonate NADP oxidoreductase activity is not diminished in either sex. The fall in gulonolactone hydrolase activity is followed by a significant fall in hepatic ascorbate content. Differences in both gulonolactone hydrolase and hepatic ascorbate, dependent on sex, are obliterated after 9 days of fasting.
Abstract Steroid hormones are vital to numerous physiological processes including cell growth, sexual development, maintenance of salt balance and sugar metabolism. Many of these activities are known to be contingent upon the binding of steroids to specific cytosolic protein receptors and the subsequent interaction of the steroid receptor complex with chromatin (Jensen et al., 1962).
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