Objective
To explore the clinical curative effect of the Taohong-Siwu decoction combined with manipulation in the treatment of the acute phase of lumbar disc herniation (LDH) and its effect on serum inflammatory factors.
Methods
According to the random number table method, 102 patients with the acute phase of LDH were divided into control group and research group from May 2014 to September 2016, 51 cases in each group. Patients in control group were treated by traction and non-steroidal anti-inflammatory drug for a month, while patients in research group were treated by manipulation combined with Taohong-Siwu decoction for a month. After treatment, the overall efficacy was observed. The Visual analogous scale (VAS) and JOA scores were recorded before and after the treatment. The IL-1β, IL-6 and TNF-α levels of inflammatory factors were detected by enzyme-linked immunosorbent assay.
Results
The total effective rate of patients in research roup was significantly higher than that of the control group [90.20% (46/51) vs. 43.14% (22/51), χ2=19.329, P=0.006]. After treatment, the VAS scores of patients in both groups were significantly decreased, and JOA score increased markedly, which the differences were statistically significant (Ps<0.05). After treatment, the VAS score of research group was significantly lower than the control group (4.26 ± 0.56 vs. 5.13 ± 0.87; t=4.843, P=0.027), and JOA score was significantly higher than the control group (18.42 ± 3.92 vs. 17.33 ± 4.21; t=5.127, P=0.022). After treatment, the IL-1β, IL-6 and TNF-α levels of of patients in the research group were significantly lower than those of the control group (0.57 ± 0.11 μg/L vs. 0.90 ± 0.13 μg/L, 112.26 ± 15.17 μg/L vs. 130.38 ± 18.29 μg/L, 2.01 ± 0.34 μg/L vs. 2.37 ± 0.51 μg/L; t=5.429, 6.317, 5.011, P<0.05).
Conclusions
The Taohong-Siwu decoction combined with manipulation on treatment of the acute phase of LDH was effective. The combined therapy can improve the VAS score and JOA score, and reduce the levels of inflammatory cytokines.
Key words:
Intervertebral disc displacement; Muscle-tendon relaxing reduction; Tao Hong Si Wu Tang; Interleukin-1β; Interleukin-1; Tumor necrosis factor alpha
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