Ya‐Na Wu

National Cheng Kung University

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Dar‐Bin Shieh

National Cheng Kung University

Robert R. Reisz

Jilin University

Pai‐Chi Li

National Taiwan University

Chi‐Kuang Sun

National Taiwan University

Li‐Xing Yang

National Cheng Kung University

Pei‐Wen Wang

Nanjing Medical University

Shang‐Rung Wu

National Cheng Kung University

Filip Braet

University of Sydney

Xuan-Yu Shi

National Health Research Institutes

Chen‐Wei Wei

Guangxi University of Science and Technology

Cooperative Institutions

National Cheng Kung University

National Taiwan University

National Cheng Kung University Hospital

National Chung Cheng University

National Chung Hsing University

National Yang Ming Chiao Tung University

University of Sydney

National Taipei University

National Tsing Hua University

National Taiwan University of Science and Technology

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From Microenvironment Remediation to Novel Anti-Cancer Strategy: The Emergence of Zero Valent Iron Nanoparticles

Pharmaceutics (2022)

Ya‐Na Wu Li‐Xing Yang Pei‐Wen Wang Filip Braet Dar‐Bin Shieh

Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in vivo. The anti-cancer activity of ZVI-based nanoparticles was anti-proportional to the oxidative status of the materials, which indicates that the elemental iron is crucial for the observed cancer selectivity. In this thematic article, distinctive endogenous anti-cancer mechanisms of ZVI-related nanomaterials at the cellular and molecular levels are reviewed, including the related gene modulating profile in vitro and in vivo. From a material science perspective, the underlying mechanisms are also analyzed. In summary, ZVI-based nanomaterials demonstrated prominent potential in precision medicine to modulate both programmed cell death of cancer cells, as well as the tumor microenvironment. We believe that this will inspire advanced anti-cancer therapy in the future.

Zerovalent iron

Nanomaterials

10.3390/pharmaceutics14010099

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Citations (6)

Surface functionalization of carbon nanomaterials by self‐assembling hydrophobin proteins

Biopolymers (2012)

Wenrong Yang Qin Ren Ya‐Na Wu Vanessa K. Morris Anthony A. Rey

Class I fungal hydrophobins are small surface-active proteins that self-assemble to form amphipathic monolayers composed of amyloid-like rodlets. The monolayers are extremely robust and can adsorb onto both hydrophobic and hydrophilic surfaces to reverse their wettability. This adherence is particularly strong for hydrophobic materials. In this report, we show that the class I hydrophobins EAS and HYD3 can self-assemble to form a single-molecule thick coating on a range of nanomaterials, including single-walled carbon nanotubes (SWCNTs), graphene sheets, highly oriented pyrolytic graphite, and mica. Moreover, coating by class I hydrophobin results in a stable, dispersed preparation of SWCNTs in aqueous solutions. No cytotoxicity is detected when hydrophobin or hydrophobin-coated SWCNTs are incubated with Caco-2 cells in vitro. In addition, we are able to specifically introduce covalently linked chemical moieties to the hydrophilic side of the rodlet monolayer. Hence, class I hydrophobins provide a simple and effective strategy for controlling the surfaces of a range of materials at a molecular level and exhibit strong potential for biomedical applications.

Hydrophobin

Surface Modification

Nanomaterials

Pyrolytic carbon

10.1002/bip.22146

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Citations (36)

The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy

Biomaterials (2011)

Ya‐Na Wu Li‐Xing Yang Xuan-Yu Shi I-Chen Li Joanna Biazik

10.1016/j.biomaterials.2011.03.006

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Citations (146)

Measurements used in morphometric analyses from Dietary adaptions in the ultrastructure of dinosaur dentine

Figshare (2016)

Kirstin S. Brink Yu‐Cheng Chen Ya‐Na Wu Wei‐Min Liu Dar‐Bin Shieh

Teeth are key to understanding the feeding ecology of both extant and extinct vertebrates. Recent studies have highlighted the previously unrecognized complexity of dinosaur dentitions and how specific tooth tissues and tooth shapes differ between taxa with different diets. However, it is unknown how the ultrastructure of these tooth tissues contributes to the differences in feeding style between taxa. In this study, we use third harmonic generation microscopy and scanning electron microscopy to examine the ultrastructure of the dentine in herbivorous and carnivorous dinosaurs to understand how the structure of this tissue contributes to the overall utility of the tooth. Morphometric analyses of dentinal tubule diameter, density and branching rates reveal a strong signal for dietary preferences, with herbivorous saurischian and ornithischian dinosaurs consistently having higher dentinal tubule density than their carnivorous relatives. We hypothesize that this relates to the hardness of the dentine, where herbivorous taxa have dentine that is more resistant to breakage and wear at the dentine–enamel junction than carnivorous taxa. This study advocates the detailed study of dentine and the use of advanced microscopy techniques to understand the evolution of dentition and feeding ecology in extinct vertebrates.

10.6084/m9.figshare.4265072

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Solid-state synthesis of monocrystalline iron oxide nanoparticle based ferrofluid suitable for magnetic resonance imaging contrast application

Nanotechnology (2007)

Jun Lü Shihe Yang Ka Ming Ng Chia-Hao Su Chen‐Sheng Yeh

The authors regret that there was an error in the final published version of this article. There is a misprint in the concentration of maghemite nanoparticles colloid used in the in vitro biocompatibility test. In line 6 of the figure caption for Figure 7 of page 5818, `10 mg ml-1 of nanoparticles, should be corrected to `10-1 mg Fe ml-1 of nanoparticles,. The conclusions of the paper do not change.

Ferrofluid

Maghemite

Biocompatibility

Iron oxide nanoparticles

10.1088/0957-4484/18/25/289001

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Citations (1)

Mammalian Tooth Enamel Functional Sophistication Demonstrated by Combined Nanotribology and Synchrotron Radiation FTIR Analyses

SSRN Electronic Journal (2022)

Chen-Tzu Chiu Jyun-Kai Cao Pei‐Wen Wang Ya‐Na Wu Yao-Chang Lee

The teeth of limbed vertebrates used for capturing and processing food are composed of mineralized dentine covered by hypermineralized enamel, the hardest material produced by organisms. Here we combine scanning probe microscopy, depth-sensing, and spectro-microscopy (SR-FTIR) to characterize the surface ultrastructural topography, nanotribology, and chemical compositions of mammal species with various dietary habits, including omnivorous humans. Our synergistic approach shows that enamel with greater surface hardness or thickness exhibited a more salient gradient feature from the tooth surface to the Dentino-Enamel Junction (DEJ) one that corresponds to the in-situ phosphate-to-amide ratio. This gradient feature of enamel covering softer dentine is the determining factor of the amazingly robust physical property of this unique biomaterial and provides the ability to dissipate stress under loading and prevent mechanical failure. Evolutionary change in the biochemical composition and biomechanical property of mammalian dentition is related to variation in oral processing of different food materials.

Nanotribology

Tooth enamel

10.2139/ssrn.4005581

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Applications of Carbohydrate‐Gold Nanoparticles for Volumetric Flow Measurements Using an Opto‐Acoustic Technique

Journal of the Chinese Chemical Society (2008)

Chan‐Yi Yang Chen‐Wei Wei Yen‐Ping Lin Hsiao‐Chien Tseng Ya‐Na Wu

Abstract Gold nanoparticles with carbohydrate ligands attached on their surface have been synthesized and characterized with various techniques. The new nanoparticle conjugates have shown great potentials as a contrast agent for opto‐acoustic imaging. Hemocompatibility measurements of human blood for the carbohydrate‐gold nanoparticles have shown that the conjugates are feasible for in vivo testing. Preliminary quantitative flow measurements using the conjugates were also studied in this work based on the indicator‐dilution theory. In vitro phantom experiments were designed and conducted, and results were discussed.

Conjugate

10.1002/jccs.200800016

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Spectral evidence on the plasmon-resonant enhanced third-harmonic χ<sup>(3)</sup> of Ag nanoparticles

Tzu‐Ming Liu Shih-Peng Tai Shi‐Wei Chu Tsung-Han Tsai Szu‐Yu Chen

Spectral dependent values of the third-harmonic-generation susceptibility chi ⁽³⁾ (3omega:omega,omega,omega) of Ag-nanoparticles have been successfully determined. When the third-harmonic-generation wavelength coincides with the Ag-nanoparticlespsila plasmon-resonant frequency, strong chi ⁽³⁾ (3omega:omega,omega,omega) enhancement is experimentally proved for the first time.

10.1109/cleo.2006.4628982

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in vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods

Nature Precedings (2008)

Pai‐Chi Li Dar‐Bin Shieh Churng-Ren Wang Chen‐Wei Wei Chao-Kang Liao

Abstract The use of gold nanorods for photoacoustic molecular imaging in vivo with simultaneous multiple selective targeting is reported. The extravasation of multiple molecular probes is demonstrated, and used to probe molecular information of cancer cells. This technique allows molecular profiles representing tumor characteristics to be obtained and a heterogeneous population of cancer cells in a lesion to be determined. The results also show that the image contrast can be enhanced by using a mixture of different molecular probes. In this study, HER2, EGFR, and CXCR4 were chosen as the primary target molecules for examining two types of cancer cells, OECM1 and Cal27. OECM1 cells overexpressed HER2 but exhibited a low expression of EGFR, while Cal27 cells showed the opposite expression profile. Single and double targeting resulted in signal enhancements of up to 3 dB and up to 5 dB, respectively, and hence has potential in improving cancer diagnoses.

Molecular Imaging

Nanorod

Molecular probe

10.1038/npre.2008.1687.1

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Citations (7)

Adolescents' Paternal Attachment and Internet Use

CyberPsychology & Behavior (2007)

Li Lei Ya‐Na Wu

As children approach middle childhood and adolescence, the influence of fathers on children's behavior and development becomes more equivalent to that of mothers. The quality of father–child attachment operates as a stronger predictor of adolescents' cognitive and emotional development. During adolescence, symbolic communication by means of the Internet becomes increasingly more important than physical approximate-seeking behavior in infancy and childhood. Adolescents might regard the Internet as their new attachment figure or may seek new attachment figures through the Internet. This study was designed to address the impacts of father–adolescent attachment on adolescents' Internet use. Seven hundred twelve adolescent participants completed questionnaires to assess the associations among their paternal attachment, intensity of Internet use, and Internet services preference. The result revealed that alienation positively predicted pathological Internet use (PIU) directly and also indirectly mediated by leisure services preference. Trust predicted PIU negatively. These results help to provide parents and educators with guidance in adolescents' more appropriate Internet use.

10.1089/cpb.2007.9976

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Citations (152)