Byung‐Soon Hwang

Korea Research Institute of Bioscience and Biotechnology

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Hae Ju Kang

Rural Development Administration

Chun‐Zhi Jin

Korea Research Institute of Bioscience and Biotechnology

Wen‐Jun Li

Sun Yat-sen University

In Guk Hwang

Rural Development Administration

Mi Jang

Korea Food Research Institute

Gi-Chang Kim

Korea Institute of Radiological and Medical Sciences

Chang‐Jin Kim

Korea Research Institute of Bioscience and Biotechnology

D.-J. Park

Korea Research Institute of Bioscience and Biotechnology

Sang‐Tae Seo

Korea Forest Service

Min‐Jiao Liu

Korea Research Institute of Bioscience and Biotechnology

Cooperative Institutions

Korea Research Institute of Bioscience and Biotechnology

Rural Development Administration

Korea University of Science and Technology

Instituto de Ciencias Agrarias

Kyushu University

Yunnan University

National Academy of Agricultural Science

Chung-Ang University

Dalian University of Technology

Beijing Institute of Technology

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Anti-Aging Effects of Antirrhinum majus L. Extract on UVB-Induced Human Skin Fibroblasts

Journal of the Korean Society of Food Science and Nutrition (2020)

Mi Jang In Guk Hwang Hae Ju Kang Byung‐Soon Hwang Gi-Chang Kim

UVB 노출에 의한 피부의 탄력감소 및 주름은 콜라겐 분해 효소인 MMPs와 type-1 콜라겐 생성과 매우 관련이 깊다. 본 실험에서는 금어초 추출물이 UVB 노출에 의해 유도된 콜라겐 분해효소인 MMP-1 생성과 콜라겐 합성에 어떠한 영향을 주는지 조사하였다. 그 결과 금어초 추출물은 세포내외로 분비되는 MMP-1의 생성을 유의적으로 억제하고 콜라겐의 합성을 촉진시키는 효과를 보였다. 그리고 세포내에서 MMP-1 발현과 관련이 깊은 mRNA 전사는 억제하고 type-1 콜라겐과 연계된 mRNA 전사는 촉진한다는 결과를 확인했다. 이는 금어초 추출물의 처리가 UVB에 노출된 피부의 탄력감소 및 주름 개선에 있어 긍정적인 효과가 있음을 시사하는 바이다. 이러한 효과는 금어초가 함유하고 있는 다양한 플라보노이드 성분에 기인하는 것으로 추정되며 식물 추출물에서 더 나아가 단일 혹은 복합성분에 대한 추가적인 연구가 필요할 것으로 생각된다. 또한, 효과를 보인 성분에 대해서 ROS의 라디칼 소거 및 MMP-1 생성과의 복합적인 상관관계에 대한 명확한 기작 연구가 수행된다면 금어초가 피부 건강과 관련된 유망한 기능성 소재가 될 것으로 생각된다.

Antirrhinum majus

Skin Aging

Human skin

10.3746/jkfn.2020.49.8.788

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Screening, isolation and evaluation of a nematicidal compound from actinomycetes against the pine wood nematode, Bursaphelenchus xylophilus

Pest Management Science (2018)

Min‐Jiao Liu Byung‐Soon Hwang Chun‐Zhi Jin Wen‐Jun Li D.-J. Park

Bursaphelenchus xylophilus is a migratory endoparasitic nematode known to cause severe environmental damage and economic losses in pine forest ecosystems. This present study investigated the nematicidal metabolites of actinomycetes in vitro and evaluated the disease control efficacy of the active compound and metabolites under greenhouse and field conditions.Five thousand types of actinobacteria from Korean forest soil samples were screened to identify novel nematicidal agents against the pine wood nematode. Streptomyces sp. AN091965 showed the strongest nematicidal activity. One active compound, spectinabilin, was obtained by nematicidal asssy-directed fractionation, and it showed significant nematicidal activity against B. xylophilus, with an LC50 value of 0.84 µg mL-1 . Spectinabilin effectively suppressed the development of pine wilt disease in 5-year-old Pinus densiflora trees, even at 0.9 mg per tree under greenhouse conditions. Moreover, the acetone extract of the active strain's mycelia efficiently suppressed the development of pine wilt disease under field conditions.To the best of our knowledge, this the first report to describe the nematicidal activity of spectinabilin against B. xylophilus. The cell extracts described herein merit further field studies as potential nematicides against the pine wood nematode. © 2018 Society of Chemical Industry.

Xylophilus

Wilt disease

Pinus densiflora

10.1002/ps.5272

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Citations (49)