Soumita Mukherjee

Bose Institute

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Manojit Pal

University of Hyderabad

Subrata Dasgupta

Central Institute of Fisheries Education

Binay K. Ghorai

Indian Institute of Engineering Science and Technology, Shibpur

R. Gangadhara Chary

L V Prasad Eye Institute

G. Rajeshwar Reddy

Dr. Reddy's Laboratories (India)

Sujit S. Panja

Czech Academy of Sciences, Institute of Physics

Bishnu P. Mukhopadhyay

National Institute of Technology Durgapur

K. Mukkanti

Jawaharlal Nehru Technological University, Hyderabad

Utpal Adhikari

National Institute of Technology Durgapur

Girdhar Singh Deora

Monash University

Cooperative Institutions

University of Hyderabad

Dr. Reddy's Laboratories (India)

Institute of Life Sciences

Jawaharlal Nehru Technological University, Hyderabad

Indian Institute of Chemical Technology

National Institute of Technology Durgapur

Dr. Reddy's Laboratories (United States)

Acharya Nagarjuna University

Bose Institute

Pharmac

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Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors

Organic & Biomolecular Chemistry (2013)

Dhilli Rao Gorja Soumita Mukherjee Chandana Lakshmi T. Meda Girdhar Singh Deora K. Lalith Kumar

A new strategy for converting antipsychotic drug olanzapine into PDE4 inhibitors is described via the design and Pd/C mediated synthesis of novel N-indolylmethyl olanzapine derivatives. One compound showed good inhibition (IC50 1.1 μM) and >10 fold selectivity towards PDE4B over D that was supported by docking studies. This compound also showed significant inhibition of TNF-α and no major toxicities in cell lines and a zebrafish embryo model except the teratogenic effects to be re-assessed in rodents.

Docking (animal)

IC50

10.1039/c3ob27424a

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Citations (29)

Multicomponent Approach for the Synthesis of Phenanthridine and Acridine Ring Systems via the Coupling of Fischer Carbene Complexes with Heteroaromatic o-Alkynyl Carbonyl Derivatives

Synthesis (2010)

Binay K. Ghorai Gouranga P. Jana Soumita Mukherjee

A one-pot multicomponent synthesis of phenanthridine and acridine derivatives is described. This method includes the in situ generation of furo[3,4-c]isoquinoline and furo[3,4-b]quinoline intermediates by the coupling of heteroaromatic o-alkynyl carbonyl derivatives with Fischer carbene complexes and subsequent trapping of these intermediates by suitable dienophiles.

Phenanthridine

Acridine

Isoquinoline

Quinoline

10.1055/s-0030-1258180

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Citations (1)

ChemInform Abstract: β‐Cyclodextrin Mediated MCR in Water: Synthesis of Dihydroisoindolo[2,1‐a]quinazoline‐5,11‐dione Derivatives under Microwave Irradiation.

ChemInform (2014)

G. Rajeshwar Reddy T. Ram Reddy R. Gangadhara Chary Suju C. Joseph Soumita Mukherjee

10.1002/chin.201415188

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Citations (0)

Zebrafish based strategy for the identification of a potential pharmacophore for apoptosis: a greener CuAAC approach for novel 1,2,3-triazoles derived from mefenamic acid

RSC Advances (2013)

P. Vijaya Babu Soumita Mukherjee Dhilli Rao Gorja Swapna Yellanki Raghavender Medisetti

Prompted by the potential of a screening strategy in zebrafish for the identification of valuable pharmacophores, a series of triazole substituted mefenamic acid derivatives were designed and synthesized via a CuAAC under green conditions. A variety of terminal alkynes were reacted with the azide obtained from mefenamic acid to give the expected products in good to excellent yields. When screened for apoptosis, teratogenicity and hepatotoxicity in zebrafish embryos, one of these compounds showed encouraging apoptotic properties and safety profiles and seemed to have medicinal value.

Mefenamic acid

10.1039/c3ra46185h

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Citations (19)

Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo

Organic & Biomolecular Chemistry (2013)

P. Vijaya Babu Soumita Mukherjee Girdhar Singh Deora Keerthana Sarma Chennubhotla Raghavender Medisetti

A series of 1,3-disubstituted pyrrolo[2,3-b]quinoxalines has been designed for the potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer catalyst) free intramolecular Heck cyclization strategy was used to prepare these compounds, some of which showed significant inhibition of PDE4B (IC50 ≈ 5–14 μM) and growth inhibition of oral cancer cells (CAL 27) but not inhibition of luciferase in vitro. They also showed acceptable safety profiles but no apoptosis in zebrafish embryos.

Heck Reaction

10.1039/c3ob41504j

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Citations (28)

Pd/C–Cu mediated direct and one-pot synthesis of γ-ylidene butenolides

Tetrahedron Letters (2013)

D. Rambabu S. Bhavani Kumara Swamy Nalivela Soumita Mukherjee Mandava Venkata Basaveswara Rao

10.1016/j.tetlet.2013.02.040

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Citations (19)

Phosphorylation of Ku70 subunit by cell cycle kinases modulates the replication related function of Ku heterodimer

Nucleic Acids Research (2016)

Soumita Mukherjee Prabal Chakraborty Partha Saha

The Ku protein, a heterodimer of Ku70 and Ku80, binds to chromosomal replication origins maximally at G1-phase and plays an essential role in assembly of origin recognition complex. However, the mechanism regulating such a critical periodic activity of Ku remained unknown. Here, we establish human Ku70 as a novel target of cyclin B1-Cdk1, which phosphorylates it in a Cy-motif dependent manner. Interestingly, cyclin E1- and A2-Cdk2 also phosphorylate Ku70, and as a result, the protein remains in a phosphorylated state during S-M phases of cell cycle. Intriguingly, the phosphorylation of Ku70 by cyclin-Cdks abolishes the interaction of Ku protein with replication origin due to disruption of the dimer. Furthermore, Ku70 is dephosphorylated in G1-phase, when Ku interacts with replication origin maximally. Strikingly, the over-expression of Ku70 with non-phosphorylable Cdk targets enhances the episomal replication of Ors8 origin and induces rereplication in HeLa cells, substantiating a preventive role of Ku phosphorylation in premature and untimely licensing of replication origin. Therefore, periodic phosphorylation of Ku70 by cyclin-Cdks prevents the interaction of Ku with replication origin after initiation events in S-phase and the dephosphorylation at the end of mitosis facilitates its participation in pre-replication complex formation.

Origin recognition complex

Pre-replication complex

Ku70

Replication factor C

Licensing factor

Cyclin A

Replication protein A

Phosphorylation cascade

10.1093/nar/gkw622

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Citations (17)

A comparative theoretical investigation on the hydride transfer process of trans and gauche conformers of phenylethylamine and norepinephrine with lumiflavin

Zenodo (CERN European Organization for Nuclear Research) (2020)

Subrata Dasgupta Soumita Mukherjee Bishnu P. Mukhopadhyay

Conformational isomerism

10.5281/zenodo.5654166

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Citations (0)

ChemInform Abstract: Zebrafish Based Strategy for the Identification of a Potential Pharmacophore for Apoptosis: A Greener CuAAC Approach for Novel 1,2,3‐Triazoles Derived from Mefenamic Acid.

ChemInform (2014)

P. Vijaya Babu Soumita Mukherjee Dhilli Rao Gorja Swapna Yellanki Raghavender Medisetti

Abstract A wide range of 1,2,3‐triazoles derived from benzylic azide (I) are synthesized and tested in a new zebrafish based assay for the identification of a new pharmacophore for apoptosis.

Mefenamic acid

Identification

10.1002/chin.201438136

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14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

Journal of Biological Chemistry (2024)

Soumita Mukherjee S.C. Roy Shruti Mukherjee Amaravadhi Harikishore Anirban Bhunia

The cAMP/PKA and mitogen-activated protein kinase (MAPK) signaling cascade control many cellular processes and are highly regulated for optimal cellular responses upon external stimuli. Phosphodiesterase 8A (PDE8A) is an important regulator that inhibits signaling via cAMP-dependent PKA by hydrolyzing intracellular cAMP pool. Conversely, PDE8A activates the MAPK pathway by protecting CRAF/Raf1 kinase from PKA-mediated inhibitory phosphorylation at Ser259 residue, a binding site of scaffold protein 14-3-3. It still remains enigmatic as to how the cross-talk involving PDE8A regulation influences cAMP/PKA and MAPK signaling pathways. Here, we report that PDE8A interacts with 14-3-3ζ in both yeast and mammalian system, and this interaction is enhanced upon the activation of PKA, which phosphorylates PDE8A's Ser359 residue. Biophysical characterization of phospho-Ser359 peptide with 14-3-3ζ protein further supports their interaction. Strikingly, 14-3-3ζ reduces the catalytic activity of PDE8A, which upregulates the cAMP/PKA pathway while the MAPK pathway is downregulated. Moreover, 14-3-3ζ in complex with PDE8A and cAMP-bound regulatory subunit of PKA, RIα, delays the deactivation of PKA signaling. Our results define 14-3-3ζ as a molecular switch that operates signaling between cAMP/PKA and MAPK by associating with PDE8A.

10.1016/j.jbc.2024.105725

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Citations (1)