Prabhat Arya

University of Hyderabad

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Michaël Prakesch

Ontario Institute for Cancer Research

Donald M. Leek

National Research Council Canada

Reni Joseph

Steacie Institute for Molecular Sciences

Shahriar Khadem

Health Canada

Kristina M. K. Kutterer

Pearl River Community College

Robert N. Ben

University of Ottawa

Satish Srinivas Kitambi

King Institute of Preventive Medicine and Research

Bhanudas Dasari

Inserm

Doug T. H. Chou

Simon Fraser University

Ravikumar Jimmidi

Baylor College of Medicine

Cooperative Institutions

Steacie Institute for Molecular Sciences

University of Ottawa

Ontario Institute for Cancer Research

University of Hyderabad

National Academies of Sciences, Engineering, and Medicine

Institute of Life Sciences

McGill University

National Research Council Canada

Centre National de la Recherche Scientifique

Indian Institute of Chemical Technology

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High-throughput Chemistry toward Complex Carbohydrates and Carbohydrate-like Compounds a

Combinatorial Chemistry & High Throughput Screening (2002)

Karla D. Randell Angela Barkley Prabhat Arya

In the area of peptide and nucleic acid chemistry and biology, high-throughput synthesis has played an important role in providing useful small-molecule-based chemical probes in understanding the structure and function relationships. The past several years, there has been a constant rise in interest toward understanding the biological roles and functions of another important class of biomolecules, i.e., carbohydrates and carbohydrate conjugates. Although at early stages, in recent years, several groups have developed high-throughput synthetic methods to obtain complex carbohydrates or carbohydrate-like small-molecules. The present review article summarizes some of these developments.

Biomolecule

Carbohydrate chemistry

Chemical Biology

10.2174/1386207024607374

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Citations (4)

Divergent Approach to Building a Latrunculin Family Derived Hybrid Macrocyclic Toolbox

Organic Letters (2015)

Madhu Aeluri Bhanudas Dasari Prabhat Arya

A divergent approach to obtain a latrunculin family based hybrid macrocyclic toolbox is developed. A practical, stereoselective synthesis of a common substructure present in latrunculin A and latrunculol A was achieved. This was further utilized in the macrocyclic diversity synthesis. The amino acid moiety embedded in the 15-membered macrocyclic ring allows for the exploration of various chiral side chains as one of the diversity sites.

Moiety

Toolbox

Side chain

10.1021/ol503465p

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Citations (9)

Solution- and Solid-Phase Synthesis of Tetrahydroquinoline-Based Polycyclics Having α,β-Unsaturated γ-Lactam and δ-Lactone Functionalities

Synlett (2009)

Shahriar Khadem K.A. Udachin Prabhat Arya

With the goal of the library generation using the tetrahydroquinoline-based derivative, a simple and practical enantioselective synthesis of the tetrahydroquinoline derivatives having α,β-unsaturated γ-lactam and δ-lactone functional groups was achieved. The phenolic hydroxy group in the α,β-unsaturated γ-lactam was utilized as an anchoring site for the solid-phase synthesis. The ring-closing metathesis approach yielded the desired tricyclic products on the solid phase.

Lactam

Ring-Closing Metathesis

Solid-Phase Synthesis

Derivative (finance)

Tricyclic

10.1055/s-0029-1218576

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Citations (9)

A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay

European Journal of Organic Chemistry (2013)

Srinivas Chamakuri Shiva Krishna Reddy Guduru Sreedhar Pamu Gayathri Chandrasekar Satish Srinivas Kitambi

Abstract A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent “stitching technology”. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.

Moiety

Image stitching

Chemical space

10.1002/ejoc.201300409

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Citations (12)

Carbonylation Reactions of Iodoarenes with PAMAM Dendrimer-Palladium Catalysts Immobilized on Silica

The Journal of Organic Chemistry (2002)

Shlomo Antebi Prabhat Arya Leo E. Manzer Howard Alper

Palladium complexes immobilized onto generation 0-3 PAMAM dendrimers supported on silica were used as catalysts for the carbonylation of iodobenzene in methanol to form methyl benzoate. High yields were obtained and the catalyst was recycled 4-5 times without significant loss of activity. The carbonylation reaction was found to be applicable to a variety of iodoarenes regardless of the nature of the substituent.

Iodobenzene

Carbonylation

10.1021/jo020271n

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Citations (99)

Synthesis and biological evaluation of rapamycin-derived, next generation small molecules

MedChemComm (2017)

Shiva Krishna Reddy Guduru Prabhat Arya

Over the years, rapamycin has attracted serious attention due to its remarkable biological properties and as a potent inhibitor of the mammalian target of rapamycin (mTOR) protein through its binding with FKBP-12. Several efficient strategies that utilize synthetic and biosynthetic approaches have been utilized to develop small molecule rapamycin analogs or for synthesizing hybrid compounds containing a partial rapamycin structure to improve pharmacokinetic properties. Herein, we report selected case studies related to the synthesis of rapamycin-derived compounds and hybrid molecules to explore their biological properties.

FKBP

10.1039/c7md00474e

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Citations (14)

Degradation of oleandomycin: controlled removal of sugars to give oleandonolide c3,c5-acetonide

Tetrahedron (1988)

Ian Paterson Prabhat Arya

Oleandomycin

Degradation

Acetonide

10.1016/s0040-4020(01)85115-2

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Citations (8)

Tris(trimethylsilyl)silane (TTMSS): formation of carbon-centered radicals from 1,3-dithiolanes and 1,3-dithianes

The Journal of Organic Chemistry (1990)

Prabhat Arya C. SAMSON M. Lesage D. Griller

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTris(trimethylsilyl)silane (TTMSS): formation of carbon-centered radicals from 1,3-dithiolanes and 1,3-dithianesPrabhat Arya, Connie Samson, Maurice Lesage, and David GrillerCite this: J. Org. Chem. 1990, 55, 26, 6248–6250Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://doi.org/10.1021/jo00313a008RIGHTS & PERMISSIONSArticle Views246Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (370 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

Trimethylsilyl

Ingenuity

Altmetrics

10.1021/jo00313a008

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Citations (27)

Part 1. Modular Approach to Obtaining Diverse Tetrahydroquinoline-Derived Polycyclic Skeletons for Use in High-Throughput Generation of Natural-Product-like Chemical Probes

Journal of Combinatorial Chemistry (2006)

Michaël Prakesch Utpal Sharma Maya Sharma Shahriar Khadem Donald M. Leek

A practical synthesis of a tetrahydroaminoquinoline scaffold (12) was developed that used a stereocontrolled aza Michael as the key reaction. Three tetrahydroquinoline alkaloid-like, tricyclic derivatives 16, 18, and 19 with different medium to macrocyclic ring skeletons were obtained, using this scaffold as the starting material, in a modular manner. The macrocyclic compounds with an isolated olefin and an electron-deficient olefin were obtained by ring-closing metathesis approaches. Compounds 16 and 18 are unique and contain bridged 10- and 12-membered functionalized rings. The NMR studies of these compounds revealed interesting information on the conformation of the bicyclic scaffolds that was dependent on the nature and the size of the macrocyclic rings. Finally, this modular methodology, using compound 21 anchored onto the solid support, successfully led to the generation of different macrocyclic derivatives, 23, 25, and 27 in solid-phase synthesis. The solid-phase synthesis approach outlined in this article has the potential to generate tetrahydroquinoline-based tricyclic compounds containing different medium to macrocyclic architectures.

Olefin Metathesis

Solid-Phase Synthesis

Natural product

10.1021/cc060055i

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Citations (26)

Combinatorial Chemistry in the Age of Chemical Genomics

ChemInform (2006)

Reni Joseph Prabhat Arya

Abstract For Abstract see ChemInform Abstract in Full Text.

10.1002/chin.200605256

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Citations (0)