It had been well known that the chromosome no.9 showed a high susceptibility for the structural rearrangements in the somatic chromosomes.In a chromosome survey of the congenital defectives for the clinical diagnosis, a 6year-old girl was found to have an inverted chromosome of the no. 9 chromosome.The present article describes the clinical and cytogenetic evidence of this child.. Case reports.The patient was a 6-year-old and mentally retarded girl.She was born to a 25-year-old mother and a 27-year-old father as the first child in twice pregnancies.There was no history of abortion, still birth, congenital malformations, exposure to the atomic bomb, and consanguinity in this couple.The clinical examination revealed that her parents and younger brother were phenotypically normal.The patient was 3270 g in birth weight with circumference of 34 cm of the head and 32 cm of the breast, and with 50 cm in length at 41 weeks of gestation.Her remarkable clinical findings were growth retardation, small head, flat occiput, hypertelorism, inner epicanthal fold, downward slanted palpebral fissure, internal strabismus, nystagmus, blue sclera, malpigmentation of the eye grounds, low-set ears, malformed and large ears, preauricular tag on left, broad and low nasal bridge, large and protruding tongue, malaligned teeth, wide spread nipple, pigmented nevus on the chest, incurved and shortened little finger of both hands, talipes varus at left, and mental retardation:imbecile.Computed tomography revealed that her cerebral ventricle was slightly dilated.Her electroencephalogram was normal.Cytological findings.The chromosome preparations were made on the leucocyte cultures from the patient.The G-and C-banding differential stainings were also applied for the chromosome identifications.The chromosome counts were made with 24 well-delineated metaphases.The karyotype was analysed in 5 cells by the conventional Giemsa staining, and 5 cells each by G-, and C-banding analyses.The chromosome constitution of the patient based on the conventional Giemsa specimen showed 46 chromosomes which included the no. 9 chromosome having an unusually elongated short and shortened long arm.The G-, and C-banding analyses revealed that one of the no. 9 chromosomes showed the pericentric inversion at p11--~q13.Then the patient karyotype was given as 46,XX,inv(9) (p11g13).The chromosomal examination of her parents was not cooperated.Remarks and conclusion.The pericentric inversion of the chromosome no.9 has been reported by several authors.
To investigate the 2-year healing rate of macular edema (ME) secondary to branch retinal vein occlusion (BRVO) treated initially with intravitreal ranibizumab (IVR) and later combined with other treatment as needed, and the characteristics of refractory cases.130 patients (130 eyes) with BRVO-ME who received IVR initially were studied. Anti-vascular endothelial growth factor drug was additionally administered when ME relapsed or persisted. Photocoagulation was performed when the non-perfusion area (NPA) was ≥5 disc diameter (DD), and/or when ME relapsed due to microaneurysm. Patients were classified into a healed group [ME resolved in <2 years or mild ME remained without best-corrected visual acuity (BCVA) loss for ≥6 months] or refractory group (ME persisted for ≥2 years).110 eyes were classified into the healed group, and 20 eyes into the refractory group. The healed group and refractory group had, respectively, mean follow-up periods of 21.2 and 37.4 months, and frequencies of NPA ≥5 DD of 55.5 and 25.0% (p = 0.015). In the healed group, mean BCVA (logMAR) improved significantly compared to baseline in all the periods until 24 months after treatment initiation and at the last visit (p<0.001). In the refractory group, mean BCVA improved significantly compared to baseline until 12 months after treatment initiation (p<0.05 for all periods), but was not significantly different at 18 or 24 months or at the last visit.In patients with BRVO-ME treated initially with IVR and later given additional treatments as needed, the healing rate was 84.6%. In eyes that healed within 2 years, BCVA improved relative to baseline throughout 24 months and at the last visit. In refractory eyes, BCVA improved only until 12 months, and thereafter deteriorated to baseline level at the last examination.
Faith of Hikawa means Shinto religion for Hikawa God and Goddess, which is originated from the syncretization of Susanoo-no-Mikoto and his family with the deities of Minuma Lake and Arakawa River. Hikawa Shrines are spread around the basin of Arakawa and Motoarakawa Rivers. This research is on the construction of Hikawa Nyotai Shrine in Midori Ward of Saitama City, which is dedicated for Kushinadahime-no-Mikoto (Hikawa Goddess). The main shrine (Honden) is said to have been constructed in 1667 with the evidence of Munafuda noting the date of construction. Its front shrine (Haiden) and hall of offerings (Heiden), however, were not determined of their construction date, because of the architectural details and historical documents written in 1688-89. In 2011 and 2012, dismantling repair construction of the Shrine was carried out, and some facts became clear. Analyzing historical documents and pictures with these newly-revealed facts, this study estimated their most possible construction age.
The main purpose of this paper is a proposal for restoration support system of historical buildings using virtual environments. Trend has developed to restore historical Japanese buildings such as theaters as symbols of town renovation. However, the restoration of such buildings commonly encounters many difficulties such as a lack of documents, and different construction materials and structures between the old era and the present. Virtual images of a restored building should be a great help in evaluating and discussing various restoration plans. We have constructed a restoration support system for historical buildings, using virtual environments to help the design plan for indoor restoration. CAD data based on actual measurements of an old theater, Tsurukawaza in Kawagoe, were employed to construct the 3D model for the system, which ensures reproduction of the interior details of the theater. The experimental results show the effectiveness of the support system.
Jingu Choko-kan in Ise City is a historical museum, while JIngu Nogyo-kan is a museum that contains the agriculture-related materials. These museum were put in place together at Kuratayama by the Shin'en Board (Shin'en-kai), designed by Tokuma Katayama who was one of leading architects in Meiji Era. This research is on the plan and construction processes of these two museums, by means of analyses of historical documents and drawings investigated on site and in the Jingu Archives.Jingu Choko-kan had been planned from the outset of the Shin'en Board itself, but it took a long time for the actual construction because its cost was estimated too much. This study clarified Jingu Choko-kan had some plans in the process, and a feat that Tokuma Katayama was actually responsible for the design of Jingu Nogyo-kan became definite by the discovery of drawings with ‘Tokuma’ stamps. Moreover, it also became evident his efforts were especially put on the structural metal members and the shape of its central hall.
The five-year survival rate for carcinoma of the tongue usually ranges from 40 to 60 percent. Recently, it was reported that an excellent result was obtained with intra-tissue radium needle therapy, as conducted at the National Cancer Center in Tokyo. With this therapy the five-year survival rate was 60 percent. Because of the minimum disturbance in function, this therapeutic approach is probably the best available. It requires, however, special facilities which many hospitals do not have. The present paper is a discussion of treatments for carcinoma of the tongue in the absence of the facility for intra-tissue radium needle therapy.For the 34 patients treated at our hospital between 1960 and 1970, different approaches were applied on a patient to patient basis. The five year survival rate was 44 percent. The cause of death in 19 was local recurrence in 11 and cervical metastasis in 6. Thus, there was a necessity for improvement in managing the primary lesion and the cervical lymph nodes.Since 1971 we have been using a program which includes preoperative radiation and local infusion chemotherapy followed by extensive removal of the primary lesion and radical neck dissection. In some patients, the basic program was modified according to their condition. The five-year survival rate for 40 patients was 65 percent. Only one patient died of local recurrence and three died of cervical metastasis.A retrospective study and histological examination of the neck specimens appears to justify the following conclusion:(1) For T1 and T2 lesions limited within one half side of the tongue body, radiation and local infusion chemotherapy without surgical removal is frequently successful. Neck dissection in an attempt at prevention is not required.(2) For a T2 lesion extending beyond one half side of the tongue body, and the T3 lesion, treatments should include preoperative radiation and local chemotherapy followed by extensive surgical removal and radical neck dissection. Reconstructive procedures are required to minimize functional disorders.
