Mengmeng Hou

Agricultural Genomics Institute at Shenzhen

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Co-Authors

Yali Zhang

Nanjing Agricultural University

Guohua Xu

Nanjing Agricultural University

Jinfeng Zhao

Shenyang Normal University

Jinyuan Tao

Nanjing Agricultural University

Daxia Wu

Nanjing Agricultural University

Shuangjie Huang

Xinyang College of Agriculture and Forestry

Chaozheng Li

Henan Institute of Science and Technology

Koichi Yoneyama

Utsunomiya University

Xiwen Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Xiaonan Xie

Utsunomiya University

Cooperative Institutions

Nanjing Agricultural University

Chinese Academy of Sciences

Ministry of Agriculture and Rural Affairs

Sun Yat-sen University

Chinese Academy of Agricultural Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Air Force Medical University

Xijing Hospital

Shenyang Normal University

Anhui Agricultural University

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Integrated microbiology and metabolomics analysis reveal patterns and mechanisms for improving the yield and alkaloid content of Fritillaria cirrhosa by nitrogen fertilization

Industrial Crops and Products (2024)

Wenjun Jiang Xinyue Wang Lingxu Meng Mengmeng Hou Jialu Wang

Nitrogen fertilizer

10.1016/j.indcrop.2024.119000

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Citations (6)

OsPIN9, an auxin efflux carrier, is required for the regulation of rice tiller bud outgrowth by ammonium

New Phytologist (2020)

Mengmeng Hou Feifei Luo Daxia Wu Xuhong Zhang Manman Lou

Summary The degree of rice tillering is an important agronomic trait that can be markedly affected by nitrogen supply. However, less is known about how nitrogen‐regulated rice tillering is related to polar auxin transport. Compared with nitrate, ammonium induced tiller development and was paralleled with increased 3 H‐indole‐acetic acid (IAA) transport and greater auxin into the junctions. OsPIN9 , an auxin efflux carrier, was selected as the candidate gene involved in ammonium‐regulated tillering based on GeneChip data. Compared with wild‐type plants, ospin9 mutants had fewer tillers, and OsPIN9 overexpression increased the tiller number. Additionally, OsPIN9 was mainly expressed in vascular tissue of the junction and tiller buds, and encoded a membrane‐localised protein. Heterologous expression in Xenopus oocytes and yeast demonstrated that OsPIN9 is a functional auxin efflux transporter. More importantly, its RNA and protein levels were induced by ammonium but not by nitrate, and tiller numbers in mutants did not respond to nitrogen forms. Further advantages, including increased tiller number and grain yield, were observed in overexpression lines grown in the paddy field at a low‐nitrogen rate compared with at a high‐nitrogen rate. Our data revealed that ammonium supply and an auxin efflux transporter co‐ordinately control tiller bud elongation in rice.

Tiller (botany)

10.1111/nph.16901

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Citations (54)

Regulated stepwise ESDPT mechanism associated with chalcogen substitutions in BDIBD derivatives

Physical Chemistry Chemical Physics (2024)

Chang Liu Jinfeng Zhao Jiahe Chen Ming‐Wei Wang Mengmeng Hou

This work elucidates stepwise excited state intramolecular double proton transfer in BDIBD derivatives and proposes a chalcogen atomic-electronegativity-regulated excited state dynamical mechanism.

Chalcogen

10.1039/d3cp05837a

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Citations (27)

Theoretical exploring effects of solvent polarity and atomic electronegativity on excited state behaviour for BY4TP fluorophore

Molecular Physics (2024)

Liang Yang Lu Feng Mingwei Wang Jinfeng Zhao Xiaoxiao Li

As widely acknowledged, the realm of novel organic molecules boasting extraordinary attributes pertaining to excited-state intramolecular proton transfer (ESIPT) has emerged as a captivating subject matter. In this context, our primary focus lies in delving into the excited-state behaviour exhibited by 2-benzoxazol-2-yl-4-triethylsilanylethynyl-phenol (BY4TP), an alluring derivative derived from 2-(2-hydroxyphenyl)benzoxazole (HBO). Relying on the examination of four distinct aprotic solvents with varying degrees of polarities, we can unequivocally affirm that solvent polarity exerts a profound influence on the intricate interplay of hydrogen bonding interactions, charge redistribution and reorganisation, as well as associated ESIPT phenomena by light. Through meticulous comparison and precise measurement of reaction barriers across diverse solvent environments, our groundbreaking findings indicate that lowly polar solvents serve as efficacious facilitators for promoting the occurrence of the ESIPT reaction in BY4TP fluorophore. By considering atomic-electronegativity-regulated hydrogen bonding effects and excited state behaviours for BY4TP-S and BY4TP-Se, we also present low atomic electronegativity with Se substation promotes ESIPT reaction. We ardently anticipate that this study will provide invaluable insights into the behaviour exhibited by BY4TP upon excitation and under the influence of solvent polarity and atomic electronegativity, while simultaneously paving new avenues for future research endeavours and applications encompassing novel HBO derivatives.

Electronegativity

Polarity (international relations)

Solvent polarity

10.1080/00268976.2024.2326574

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The role of auxin in nitrogen-modulated shoot branching

Plant Signaling & Behavior (2021)

Mengmeng Hou Daxia Wu Ying Li Wenqing Tao Ling Chao

Shoot branching is determined by axillary bud formation and outgrowth and remains one of the most variable determinants of yield in many crops. Plant nitrogen (N) acquired mainly in the forms of nitrate and ammonium from soil, dominates plant development, and high-yield crop production relies heavily on N fertilization. In this review, the regulation of axillary bud outgrowth by N availability and forms is summarized in plant species. The mechanisms of auxin function in this process have been well characterized and reviewed, while recent literature has highlighted that auxin export from a bud plays a critical role in N-modulating this process.

Branching (polymer chemistry)

Ammonium nitrate

Apical dominance

10.1080/15592324.2021.1885888

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Citations (12)

Cascading Alignment for Unsupervised Domain-Adaptive DETR with Improved DeNoising Anchor Boxes

Sensors (2022)

Huantong Geng Jun Jiang Junye Shen Mengmeng Hou

Transformer-based object detection has recently attracted increasing interest and shown promising results. As one of the DETR-like models, DETR with improved denoising anchor boxes (DINO) produced superior performance on COCO val2017 and achieved a new state of the art. However, it often encounters challenges when applied to new scenarios where no annotated data is available, and the imaging conditions differ significantly. To alleviate this problem of domain shift, in this paper, unsupervised domain adaptive DINO via cascading alignment (CA-DINO) was proposed, which consists of attention-enhanced double discriminators (AEDD) and weak-restraints on category-level token (WROT). Specifically, AEDD is used to aggregate and align the local–global context from the feature representations of both domains while reducing the domain discrepancy before entering the transformer encoder and decoder. WROT extends Deep CORAL loss to adapt class tokens after embedding, minimizing the difference in second-order statistics between the source and target domain. Our approach is trained end to end, and experiments on two challenging benchmarks demonstrate the effectiveness of our method, which yields 41% relative improvement compared to baseline on the benchmark dataset Foggy Cityscapes, in particular.

Benchmark (surveying)

Granularity

10.3390/s22249629

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Citations (3)

Cell Cycle Regulation by Alternative Polyadenylation of CCND1

Scientific Reports (2018)

Qiong Wang Guopei He Mengmeng Hou Liutao Chen Shangwu Chen

Global shortening of 3'UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown. CCND1 is a proto-oncogene that regulates progression through the G1-S phase of the cell cycle; moreover, it has been observed to be switching to proximal APA sites in cancer cells. To investigate the biological function of the APA of CCND1, we edited the weak poly(A) signal (PAS) of the proximal APA site to a canonical PAS using the CRISPR/Cas9 method, which can force the cells to use a proximal APA site. Cell cycle profiling and proliferation assays revealed that the proximal APA sites of CCND1 accelerated the cell cycle and promoted cell proliferation, but UTR-APA and CR-APA act via different molecular mechanisms. These results indicate that PAS editing with CRISPR/Cas9 provides a good method by which to study the biological function of APA.

10.1038/s41598-018-25141-0

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Citations (60)

Three-dimensional polyaniline/cerium oxide composite aerogel with enhanced microwave absorption properties

Synthetic Metals (2022)

Mengmeng Hou Huiling Gu Ji Huang Hongtao Guan Shuangxi Xing

Nanorod

10.1016/j.synthmet.2022.117251

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Citations (6)

Diagnostic value of sputum microRNA-21 in lung cancer: A Meta-analysis

Zhonghua linchuang yishi zazhi (2021)

Han Li Rong Gao Bingdi Yan Chang‐Ying Hu Mengmeng Hou

Value (mathematics)

10.3877/cma.j.issn.1674-0785.2021.03.004

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Advances in auxin synthesis, transport, and signaling in rice: implications for stress resilience and crop improvement

Frontiers in Plant Science (2025)

Mengmeng Hou Yuanbo Zhang Xinyi Xu Hao Ai

Auxin, a crucial plant hormone, plays a pivotal role in regulating various aspects of rice growth and development, including cell elongation, root formation, and responses to environmental stimuli. Recent breakthroughs in auxin research have revealed novel regulatory mechanisms, such as the identification of auxin-related genes like DNR1 and OsARF18, which enhance rice nitrogen use efficience and resistance to glufosinate. Additionally, advancements in understanding auxin transport and signaling pathways have highlighted their potential in optimizing tillering, root architecture, and grain yield. This review examines these molecular mechanisms and their interactions with other hormones, emphasizing their integration into breeding programs for improved rice productivity. By synthesizing these findings, we provide a comprehensive overview of how auxin research informs strategies for developing rice varieties with enhanced adaptability and optimized growth, contributing to food security and sustainable agriculture.

Adaptability

Crop Productivity

10.3389/fpls.2024.1516884

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