JH Hsu

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Fabio Martelli

IRCCS Policlinico San Donato

DP Naidoo

University of KwaZulu-Natal

YM Roka-Moiia

Rodopi Stamatiou

Aristotle University of Thessaloniki

Christoph Hauser

University of Basel

Olga Karpińska

Medical University of Białystok

J Bojdo

Universidad de Granada

JM Taavitsainen

Danilo Franco

Instituto Conmemorativo Gorgas de Estudios de la Salud

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Ángel Raya

Center of Regenerative Medicine in Barcelona

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Manchester Metropolitan University

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University of Salford

Universidad de Granada

Centro Cardiologico Monzino

Istituti di Ricovero e Cura a Carattere Scientifico

King's College London

Inserm

University of Milan

Imperial College London

University of Florence

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Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary …

Cardiovascular Research (2016)

Virginio García‐Martínez C Lopez Sanchez W. Hamed W. Hamed JH Hsu

Introduction:We have previously demonstrated the ability of retinoic acid to regulate the expression the atrial specific markers AMHC-1 and Tbx5 during early cardiac chamber specification.However, the molecular mechanisms responsible for this process still remain unclear.At present, microRNAs represent a novel layer of complexity in the regulatory networks controlling gene expression during cardiovascular development.Purpose: The aim of this work is to study the intrinsic mechanism involved in this signaling pathway, since miR-133 has demonstrated to be involved in other earliest cardiac developmental processes.Methods: Our model is focused on developing chick at gastrula stages by in vitro electroporation of miR-133, a microRNA which is has been shown expressed at the level of linear cardiac tube.Results: Our results show the miR-133 expression at the level of the primitive heart tube.Moreover, or work reveals that overexpression of miR-133 suppresses AMHC-1 and Tbx5 expression.Conclusion: These data support that miR-133, a putative microRNA that targets RARB 3 ´UTR, regulates the early cardiac chamber specification via retinoic acid pathway.

10.1093/cvr/cvw149

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