V Kannan

Vellore Institute of Technology University

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Vivek Anand

The University of Texas MD Anderson Cancer Center

Sudesh Deshpande

National Hospital

S. Naidu

P. D. Hinduja Hospital and Medical Research Centre

A. Sutar

Homi Bhabha National Institute

Sachin Almel

P. D. Hinduja Hospital and Medical Research Centre

A M Pendse

P. D. Hinduja Hospital and Medical Research Centre

Ritika Harjani Hinduja

National Hospital

Manish Bhadane

Homi Bhabha National Institute

V.S. Patki

Bhabha Atomic Research Centre

R. Bajpai

Shree Guru Gobind Singh Tricentenary University

Cooperative Institutions

P. D. Hinduja Hospital and Medical Research Centre

National Hospital

Bhabha Atomic Research Centre

Central Arid Zone Research Institute

Tata Memorial Hospital

Homi Bhabha National Institute

Indian Agricultural Research Institute

Bhabha Atomic Research Center Hospital

Creative Commons

Indian Council of Agricultural Research

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Gamma-knife radiosurgery for trigeminal neuralgia

Journal of Medical Imaging and Radiation Oncology (1999)

V Kannan Chandrashekhar Deopujari Basant K. Misra Prashant Shetty Manohar Shroff

Gamma knife was installed at the PD Hinduja National Hospital and Medical Research Centre, Mumbai, India, in January 1997. In the first year of gamma-knife radiosurgery to January 1998, we treated 110 patients, of whom six had medically refractory trigeminal neuralgia. Seven treatments were administered to this group of six patients (one had bilateral neuralgia). This report evaluates the effectiveness of radiosurgery treatment in these patients. The median age of the patients was 56 years and there were five males and one female. Following Leksell stereotactic frame fixation, a magnetic resonance imaging scan was done in all. The Leksell gamma plan was used for planning. A radiosurgery dose of 70-80 Gy was delivered to the trigeminal root entry zone, 2-4 mm anterior to the junction of the pons and trigeminal nerve with a single 4 mm collimator helmet. Complete pain relief was achieved in four patients. Two had partial relief. No patient developed any radiosurgery related morbidity during the follow-up period of 5-16 months. Radiosurgery seems to be an effective approach for medically or surgically refractory trigeminal neuralgia.

Trigeminal Nerve

Refractory (planetary science)

Microvascular Decompression

10.1046/j.1440-1673.1999.433668.x

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Citations (9)

High-dose intensity-modulated radiotherapy as primary therapy for prostate cancer: Report on dosimetry aspects and acute toxicity in the Indian scenario

Journal of Cancer Research and Therapeutics (2010)

V Kannan Sandeep De Sudesh Deshpande Vivek Anand Yogesh Ghadi

Dose escalation improves local control in prostate cancer. In this study we assess the feasibility of dose escalation to prostate and / or seminal vesicles to 76 Gy with intensity-modulated radiotherapy (IMRT); report data on dosimetry and acute toxicity in 40 patients at P. D. Hinduja National Hospital and Medical Research Center, Mumbai.In the period from May 2006 to September 2008, 40 consecutive patients with localized prostate adenocarcinoma (T1- 3 N0) were definitively treated with IMRT to a dose of 76 Gy / 38 fractions. Patients were seen on a weekly basis during treatment, and one month (M1) and three months (M3) thereafter. The radiation therapy oncology group (RTOG) toxicity scale was used to evaluate acute gastrointestinal (GI) and genitourinary (GU) toxicities. Additional symptoms such as rectal blood loss, urgency, dysuria, urinary frequency, nocturia, incontinence were scored as well.All 40 patients completed treatment successfully. Acute RTOG Grade 1 and Grade 2 GI toxicities were noted in 47.5% (19 patients) and 12.5% (five patients) respectively, leaving 40% (16 patients) free of any acute toxicity. Thirty-six (90%) and four patients (10%) had Grade 0-1 and Grade 2 acute RTOG-scaled GU toxicity respectively. There was no Grade 3 or higher GI / GU toxicity.The escalated dose of 76 Gy to the prostate with IMRT was very well tolerated by all our patients with acceptable acute GU and GI toxicity, thereby, establishing the feasibility of dose escalation in the Indian scenario.

Therapeutic window

10.4103/0973-1482.63565

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Citations (4)

Dosimetry Investigation of MOSFET for Clinical IMRT Dose Verification

Technology in Cancer Research & Treatment (2013)

Sudesh Deshpande Rajesh Kumar Yogesh Ghadi R Nehru V Kannan

In IMRT, patient-specific dose verification is followed regularly at each centre. Simple and efficient dosimetry techniques play a very important role in routine clinical dosimetry QA. The MOSFET dosimeter offers several advantages over the conventional dosimeters such as its small detector size, immediate readout, immediate reuse, multiple point dose measurements. To use the MOSFET as routine clinical dosimetry system for pre-treatment dose verification in IMRT, a comprehensive set of experiments has been conducted, to investigate its linearity, reproducibility, dose rate effect and angular dependence for 6 MV x-ray beam. The MOSFETs shows a linear response with linearity coefficient of 0.992 for a dose range of 35 cGy to 427 cGy. The reproducibility of the MOSFET was measured by irradiating the MOSFET for ten consecutive irradiations in the dose range of 35 cGy to 427 cGy. The measured reproducibility of MOSFET was found to be within 4% up to 70 cGy and within 1.4% above 70 cGy. The dose rate effect on the MOSFET was investigated in the dose rate range 100 MU/min to 600 MU/min. The response of the MOSFET varies from -1.7% to 2.1%. The angular responses of the MOSFETs were measured at 10 degrees intervals from 90 to 270 degrees in an anticlockwise direction and normalized at gantry angle zero and it was found to be in the range of 0.98 ± 0.014 to 1.01 ± 0.014. The MOSFETs were calibrated in a phantom which was later used for IMRT verification. The measured calibration coefficients were found to be 1 mV/cGy and 2.995 mV/cGy in standard and high sensitivity mode respectively. The MOSFETs were used for pre-treatment dose verification in IMRT. Nine dosimeters were used for each patient to measure the dose in different plane. The average variation between calculated and measured dose at any location was within 3%. Dose verification using MOSFET and IMRT phantom was found to quick and efficient and well suited for a busy radiotherapy department.

Linearity

Dose profile

10.7785/tcrt.2012.500318

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Citations (4)

Dosimetry and treatment planning of Occu-Prosta I-125 seeds for intraocular lesions

Journal of Medical Physics (2008)

Sudesh Deshpande Suresh Chaudhari Vivek Anand Sandeep De Sanjay Kumar Saxena

Intraocular malignant lesions are frequently encountered in clinical practice. Plaque brachytherapy represents an effective means of treatment for intraocular lesions. Recently Radiopharmaceutical Division, BARC, Mumbai, has indigenously fabricated reasonable-cost I-125 sources. Here we are presenting the preliminary experience of dosimetry of sources, configuration of treatment planning system (TPS) and quality assurance (QA) for eye plaque therapy with Occu-Prosta I-125 seeds, treated in our hospital, for a patient with ocular lesions. I-125 seeds were calibrated using well-type chamber. BrachyVision TPS was configured with Monte Carlo computed radial dose functions and anisotropy functions for I-125 sources. Dose calculated by TPS at different points in central axis and off axis was compared with manually calculated dose. Eye plaque was fabricated of 17 karat pure gold, locally. The seeds were arranged in an outer ring near the edge of the plaque and in concentric rings throughout the plaque. The sources were manually digitized on the TPS, and dose distribution was calculated in three dimensions. Measured activity using cross-calibrated well-type chamber was within Â±10% of the activity specified by the supplier. Difference in TPS-calculated dose and manually calculated dose was within 5%. Treatment time calculated by TPS was in concordance with published data for similar plaque arrangement.

10.4103/0971-6203.39419

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Citations (9)

Measurement of eye lens dose for Varian On-Board Imaging with different cone-beam computed tomography acquisition techniques

Journal of Medical Physics (2016)

Sudesh Deshpande D Dhote Kalpna Thakur Amol U. Pawar Rajesh Kumar

The objective of this work was to measure patient eye lens dose for different cone-beam computed tomography (CBCT) acquisition protocols of Varian's On-Board Imaging (OBI) system using optically stimulated luminescence dosimeter (OSLD) and to study the variation in eye lens dose with patient geometry and distance of isocenter to the eye lens. During the experimental measurements, OSLD was placed on the patient between the eyebrows of both eyes in line of nose during CBCT image acquisition to measure eye lens doses. The eye lens dose measurements were carried out for three different cone-beam acquisition protocols (standard dose head, low-dose head [LDH], and high-quality head [HQH]) of Varian OBI. Measured doses were correlated with patient geometry and distance between isocenter and eye lens. Measured eye lens doses for standard head and HQH protocols were in the range of 1.8-3.2 mGy and 4.5-9.9 mGy, respectively. However, the measured eye lens dose for the LDH protocol was in the range of 0.3-0.7 mGy. The measured data indicate that eye lens dose to patient depends on the selected imaging protocol. It was also observed that eye lens dose does not depend on patient geometry but strongly depends on distance between eye lens and treatment field isocenter. However, undoubted advantages of imaging system should not be counterbalanced by inappropriate selection of imaging protocol, especially for very intense imaging protocol.

Isocenter

Eye lens

10.4103/0971-6203.189481

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Citations (3)

A Report on Clinical Outcome and Complications after High Dose Rate Brachytherapy Boost (HDR-BT) in Intermediate Risk (IR) and High-Risk (HR) Prostate Cancers

Brachytherapy (2016)

Vivek Anand V Kannan Sudesh Deshpande A. Sutar R. Bajpai

External beam radiotherapy

10.1016/j.brachy.2016.04.364

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Use of image guided radiation therapy techniques and imaging dose measurement at Indian hospitals: A survey

Journal of Medical Physics (2015)

Sudesh Deshpande DS Dhote Rajesh Kumar S. Naidu A. Sutar

A national survey was conducted to obtain information about the use of image-guided radiotherapy (IGRT) techniques and IGRT dose measurement methods being followed at Indian radiotherapy centers. A questionnaire containing parameters relevant to use of IGRT was prepared to collect the information pertaining to (i) availability and type of IGRT delivery system, (ii) frequency of image acquisition protocol and utilization of these images for different purpose, and (iii) imaging dose measurement. The questionnaire was circulated to 75 hospitals in the country having IGRT facility, and responses of 51 centers were received. Su rvey results showed that among surveyed hospitals, 86% centers have IGRT facility, 78% centers have kilo voltage three-dimensional volumetric imaging. 75% of hospitals in our study do not perform computed tomography dose index measurements and 89% of centers do not perform patient dose measurements. Moreover, only 29% physicists believe IGRT dose is additional radiation burden to patient. This study has brought into focus the need to design a national protocol for IGRT dose measurement and development of indigenous tools to perform IGRT dose measurements.

Image-guided radiation therapy

10.4103/0971-6203.170788

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Citations (5)

A Hybrid Algorithm for Optimizing Machining and Spraying Parameters in MQL-Turning of Inconel 800H

SAE technical papers on CD-ROM/SAE technical paper series (2025)

V Kannan Kotha Mokshajna

<div class="section abstract"><div class="htmlview paragraph">Inconel 800H superalloy is a difficult-to-turn material. This study aims to achieve optimal machining results, including reduced cutting force, improved surface roughness, and minimized residual stress, by optimizing input machining parameters like cutting speed, feed rate, spraying angle, and nozzle distance on Inconel 800H. The Taguchi L27 method is utilized for experimentation, while the Harris hawks optimizer (HHO) is applied in a multi-objective optimization model. Additionally, the Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS) is used to identify the optimal input parameters. Five distinct weight schemes were employed, including the Analytic Hierarchy Process (AHP), the Entropy weight method, Criteria Importance through Inter-Criteria Correlation (CRITIC), Grey relational analysis (GRA), and Principal Component Analysis (PCA) to determine response weights. The analysis revealed that the primary factor affecting all measured weights is the feed rate, with the nozzle angle closely followed, as determined by ANOVA, based on a comprehensive evaluation of all output responses. Notable enhancement in MQL turning when contrasted with dry turning, reflected in the output responses of roughness, force, and residual stress at 72.62%, 8.08%, and 19.32%, respectively, using AHP-TOPSIS compared to AHP-HHO.</div></div>

Inconel

10.4271/2025-28-0042

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Direct calibration of a reference standard against the air kerma strength primary standard, at¹⁹²Ir HDR energy

Physics in Medicine and Biology (2002)

Kamala Rajan T. Palani Selvam B.C. Bhatt M. Vijayam V.S. Patki

The primary standard of low air kerma rate sources or beams, maintained at the Radiological Standards Laboratory (RSL) of the Bhabha Atomic Research Centre (BARC), is a 60 cm3 spherical graphite ionization chamber. A 192Ir HDR source was standardized at the hospital site in units of air kerma strength (AKS) using this primary standard. A 400 cm3 bakelite chamber, functioning as a reference standard at the RSL for a long period, at low air kerma rates (compared to external beam dose rates), was calibrated against the primary standard. It was seen that the primary standard and the reference standard, both being of low Z, showed roughly the same scatter response and yielded the same calibration factor for the 400 cm3 reference chamber, with or without room scatter. However, any likelihood of change in the reference chamber calibration factor would necessitate the re-transport of the primary standard to the hospital site for re-calibration. Frequent transport of the primary standard can affect the long-term stability of the primary standard, due to its movement or other extraneous causes. The calibration of the reference standard against the primary standard at the RSL, for an industrial type 192Ir source maintained at the laboratory, showed excellent agreement with the hospital calibration, making it possible to check the reference chamber calibration at RSL itself. Further calibration procedures have been developed to offer traceable calibration of the hospital well ionization chambers.

Kerma

Primary standard

10.1088/0031-9155/47/7/304

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Citations (6)

2294: Outcomes of multifocal glioma treated with radiation therapy: a single institutional study

Radiotherapy and Oncology (2024)

Ritika Harjani Hinduja V Kannan Basant K. Mishra Vivek Anand Vinay Babu

10.1016/s0167-8140(24)02522-2

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