Abstract The interaction between the enhancing and neutralizing activities of three monoclonal antibodies (MAbs) (5‐6‐2, 6‐4‐2 and 7‐4‐1) to the spike protein of feline infectious peritonitis virus (FIPV) strain 79‐1146 was determined using feline macrophages. At a high MAb concentration, all of the three MAbs completely inhibited the FIPV infection at 37 C. However, two of them (6‐4‐2 and 7‐4‐1) enhanced FIPV infection when either the MAb concentration or reaction temperature was lowered. These MAbs also exerted an immediate infectivity‐enhancing activity for up to 10 min of reaction and by 20 min, neutralizing activities were observed. Only MAb 5‐6‐2 consistently showed neutralizing activity regardless of the reaction conditions. Competition with sera from cats experimentally infected with FIPV strain 79‐1146 or feline enteric coronavirus strain 79‐1683 showed that the two epitopes recognized by MAb 5‐6‐2 and MAb 6‐4‐2, respectively, are also recognized by the natural host.
Formyl peptide receptor 2 (FPR2) agonists can stimulate resolution of inflammation and may have utility for treatment of diseases caused by chronic inflammation, including heart failure. We report the discovery of a potent and selective FPR2 agonist and its evaluation in a mouse heart failure model. A simple linear urea with moderate agonist activity served as the starting point for optimization. Introduction of a pyrrolidinone core accessed a rigid conformation that produced potent FPR2 and FPR1 agonists. Optimization of lactam substituents led to the discovery of the FPR2 selective agonist 13c, BMS-986235/LAR-1219. In cellular assays 13c inhibited neutrophil chemotaxis and stimulated macrophage phagocytosis, key end points to promote resolution of inflammation. Cardiac structure and functional improvements were observed in a mouse heart failure model following treatment with BMS-986235/LAR-1219.
Document management systems (DMS) have widespread in major hospitals in Japan as a platform to digitize the paper-based records being out of coverage by EPR. This study aimed to examine longitudinal trends of actual use of DMS in a hospital in which EPR had been in operation, which would be conducive to planning the further information management system in the hospital. Degrees of utilization of electronic documents and templates with DMS were analyzed based on data extracted from a university-affiliated hospital with EPR. As a result, it was found that the number of electronic documents as well as scanned documents circulating at the hospital tended to increase. The result indicated that replacement of paper-based documents with electronic documents did not occur. Therefore it was anticipated that the need for DMS would continue to increase in the hospital. The methods used this study to analyze the trend of DMS utilization would be applicable to other hospitals with with a variety of DMS implementation, such as electronic storage by scanning documents or paper preservation that is compatible with EPR.
Solid-state molybdenum halide clusters with an octahedral metal framework MoX2 (or [Mo6X8]X2X4/2) (X = Cl, Br, I) are applied to catalysis. When these clusters are thermally activated in a hydrogen...
Anisotropic Nd-Fe-B powder made through hot-forming process is a promising material for high performance bonded magnet. It is important to clarify effects of various conditions in hot-deformation process on magnetic properties of anisotropic powder in order to improve them. In this study, we investigated effects of deformation temperature and strain on magnetic properties of anisotropic powder. The results showed that both of hot-deformation temperature and strain greatly influenced magnetic properties of the anisotropic powder. Consequently, the optimum temperature and strain condition to achieve the maximum hard magnetic properties were obtained. Anisotropic compression-molded bonded magnets made from hot-upset powder through the optimum condition were fabricated; the bonded magnet with the composition of Nd0.137Fe0.735Co0.067B0.055Ga0.006 showed the highest-class (BH)max value of 178 kJ/m3, on the other hand the bonded magnet with the composition of Nd0.130Dy0.016Fe0.726Co0.068B0.054Ga0.006 had not only high coercivity of 1.6 MA/m but high (BH)max of 138 kJ/m3.
Purpose: To clarify the meaning of relocation among aging Hansen’s disease survivors; to discuss care aiming to manage the negative effects of relocation and promote adaptation to new dwellings. Methods: 1) Participants: Hansen’s disease survivors who intended to move house within B sanatorium in Japan. 2) Data collection methods: Semi-structured interviews. 3) Data analysis: Qualitative and inductive analysis. Results: Five categories of meaning regarding relocation were extracted from survivors’ responses: 1. The burden of relocation after the community’s power of mutual aid and mobility had failed due to aging; 2. The burden of creating new strategies to live with multiple severe sequelae in a new environment; 3. Displeasure at the disruption of routines; 4. Dissatisfaction with the decision-making process regarding structuring the building and rooms’ layout; 5. Thinking positively to accept moving house and enjoying the new environment. Conclusion: The following points are important: 1) Patients’ living environment can affect both the occurrence and management of Hansen’s disease sequelae; 2) Hansen’s disease survivors have multiple requirements of their living environment in order to manage multiple severe sequelae; 3) Patients who have lost their sight create mental maps of their living environment; relocation entails the loss of these maps.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
In Japan, most of all the university and advanced hospitals have implemented both electronic order entry systems and electronic charting. In addition, all medical records are subjected to inspector audit for quality assurance. The record of informed consent (IC) is very important as this provides evidence of consent from the patient or patient's family and health care provider. Therefore, we developed an automatic audit system for a hospital information system (HIS) that is able to evaluate IC automatically using machine learning.
