Yukishige Yamada

Chugoku Central Hospital

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Hiroshige Nakano

National Agriculture and Food Research Organization

Akihiko Watanabe

Yamagata University

H Sawada

Nara Medical University

Yoshiyuki Nakajima

Tokyo Women's Medical University Yachiyo Medical Center

Michihiro Narikiyo

Nara Medical University

Yoshihide Shino

Toyokawa City Hospital

Tomoaki Yano

Okayama University

Teruyuki SAKAGUCHI

National Archives and Records Administration

H. Fujimoto

Tokyo National Hospital

Shiho Sugimori

Chugoku Central Hospital

Cooperative Institutions

Nara Medical University

105

Nara Medical University Hospital

National Archives and Records Administration

The University of Tokyo

Nara City Hospital

Osaka University

National Cancer Research Institute

Jikei University Kashiwa hospital

Nagoya University

Tokyo Medical and Dental University

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Study of Gastrectomy for Gastric Cancer in Patients Aged 80 Years and Older.

The Japanese Journal of Gastroenterological Surgery (1993)

Akihiko Watanabe Takashi Yamada H Sawada Yukishige Yamada Tomoaki Yano

75歳以上の高齢者胃癌切除症例78例を80歳未満 (54例) と80歳以上 (24例) に分け, その手術成績や遠隔成績を比較検討した.80歳以上では80歳未満に比べ心疾患や糖尿病などの術前併存疾患が多いため, 硬膜外麻酔を併用したり, 切除範囲やリンパ節郭清の縮小化により手術侵襲を少なくする配慮を行ったにもかかわらず, 術後合併症の発生頻度は70.8%と高く, 特に呼吸器合併症 (33.3%) や術後誰妄 (33.3%), 心不全 (20.8%) などの発生率が高かった.また転帰からみると, 80歳以上では術後合併症や他病死による死亡例が多く, 胃癌による死亡例が少なかった.したがって80歳未満の胃癌症例に対しては根治手術をめざした積極的な手術が必要と考えられるが, 80歳以上の症例に対しては硬膜外麻酔を併用したり, 術後譫妄や肺炎予防を含めた綿密な術前術後管理のもとで, 切除範囲やリンパ節郭清の縮小化をより一層徹底する必要があると考えられた.

10.5833/jjgs.26.2287

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Citations (3)

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

Clinical Cancer Research (2005)

Yuichiro Ohigashi Masayuki Sho Yukishige Yamada Yoshikazu Tsurui Kaoru Hamada

Abstract Purpose: The negative regulatory programmed death-1/programmed death-1 ligand (PD-1/PD-L) pathway in T-cell activation has been suggested to play an important role in tumor evasion from host immunity. In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery. Experimental Design: PD-L1 and PD-L2 gene expression was evaluated in 41 esophagectomy patients by real-time quantitative PCR. The protein expression was also evaluated with newly generated monoclonal antibodies that recognize human PD-L1 (MIH1) and PD-L2 (MIH18). Results: The protein and the mRNA levels of determination by immunohistochemistry and real-time quantitative PCR were closely correlated. PD-L–positive patients had a significantly poorer prognosis than the negative patients. This was more pronounced in the advanced stage of tumor than in the early stage. Furthermore, multivariate analysis indicated that PD-L status was an independent prognostic factor. Although there was no significant correlation between PD-L1 expression and tumor-infiltrating T lymphocytes, PD-L2 expression was inversely correlated with tumor-infiltrating CD8+ T cells. Conclusions: These data suggest that PD-L1 and PD-L2 status may be a new predictor of prognosis for patients with esophageal cancer and provide the rationale for developing novel immunotherapy of targeting PD-1/PD-L pathway.

Clinical Significance

10.1158/1078-0432.ccr-04-1469

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Citations (760)

A Case of Primary Malignant Melanoma of the Esophagus

Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) (2004)

Takeo Nomi Teruyuki SAKAGUCHI Yukishige Yamada Yoshiyuki Nakazima

食道原発悪性黒色腫の1例を経験したので報告する。症例は67歳, 男性。嚥下困難を主訴に近医を受診し, 上部消化管造影検査にて食道に腫瘤性病変を指摘され, 当院入院となった。上部消化管内視鏡検査による生検にて食道悪性黒色腫と診断し, 右開胸開腹下に食道亜全摘術, 胃管による後縦隔再建を施行, T2 (MP), N2, StageIIIであった。術後経過は良好であったが退院後2カ月目に肝転移, 縦隔リンパ節再発, 脳転移が出現し, 状態が急激に悪化, 術後4カ月目に死亡した。文献的検討では, 食道原発悪性黒色腫の術後2年以上生存例は腫瘍径5cm未満, 深達度T1bの症例に限られていた。

Primary (astronomy)

10.4030/jjcs1979.29.1_43

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Clinicopathologic evaluation of immunohistochemical E-cadherin expression in human gastric carcinomas

Cancer (1995)

Yoshihide Shino Akihiko Watanabe Yukishige Yamada Masahiro Tanase Takashi Yamada

Background. E-cadherin plays a crucial role in cell-cell adhesion in epithelial tissues. Recent studies have shown a correlation between decreased E-cadherin expression and cancer cell detachment. Methods. The expression of E-cadherin was immunohistochemically analyzed using antihuman E-cadherin antibody in 121 cases of human gastric carcinoma. Results. In noncancerous areas, the epithelial cells, including those with intestinal metaplasia, were stained positively in the plasma membrane. In contrast, E-cadherin expression of the cancer cells varied from case to case in primary and secondary sites. Tumors with a decrease in E-cadherin occurred significantly more frequently in undifferentiated adenocarcinoma (P < 0.05) and scirrhous type (P < 0.01). The rate of E-cadherin-negative tumors was higher in patients with peritoneal metastasis (P < 0.01) or in those with distant lymph node metastasis (P < 0.01), though the tumors with liver metastasis had relatively positive E-cadherin expression. Patterns of initial recurrence had similar results. Reduction or loss of E-cadherin expression correlated with shorter survival in patients after curative operation regardless of stage of disease. Conclusions. The decreased E-cadherin expression correlates with dedifferentiation, infiltrative tumor growth, distant metastasis, and poor survival for patients with gastric carcinoma. Thus, immunohistochemical study of E-cadherin may have clinicopathologic value for patients with gastric carcinoma. Cancer 1995; 76:2193–201.

10.1002/1097-0142(19951201)76:11<2193::aid-cncr2820761104>3.0.co;2-2

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Citations (118)

胃癌におけるFasリガンドに対する「おとり受容体」DcR3の発現

日本外科学会雑誌 (2000)

Takahama Yasushi H Sawada Yukishige Yamada Sakaguchi Akiyuki Nakajima Yoshikazu

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CLINICAL SIGNIFICANCE OF SERUM SIALIC ACID MEASUREMENT IN GASTRIC CANCER

The journal of the Japanese Practical Surgeon Society (1990)

Akihiko Watanabe Katsunori NAKATANI H Sawada Takashi Nishiwada Tohru Okumura

Serum sialic acid (SA), immunosuppressive acidic protein (IAP) and carcinoembryonic antigen (CEA) were 23.3%, 35.0% and 28.8%, respectively. Serum SA tended to be higher in stage IV, serum CEA and its positive rate tended to be higher in stage III and IV, whereas serum IAP showed significantly higher levels in stage IV with higher positive rate. Furthermore postoperative serum SA decreased in curative and non-curative resected patients, while increased in non-resected patients. Sixty % of the patients examined were positive in any of SA, IAP or CEA, and positive rate increased as stage advanced. These results suggest that the measurement of SA is useful for screening, prediction of clinical stage and postoperative follow up of gastric cancer.

Carcinoembryonic antigen

Clinical Significance

Serum concentration

10.3919/ringe1963.51.251

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A Case of Partial Appendiceal Intussusception Induced by Appendiceal Carcinoma

The Japanese Journal of Gastroenterological Surgery (2012)

Satoru Akashi Yukishige Yamada Shiho Sugimori Masahiro Ito Keiji Shimada

症例は76歳の男性で，胃癌術後外来通院中に施行した腹部CTで盲腸内にリング状に造影される腫瘤を認めた．大腸内視鏡検査では盲腸内に突出する腫瘍性病変を認め，中心部陥凹しており，虫垂根部の腫瘍が盲腸内に翻転したものと思われた．生検にて高度異型腺腫を認め，虫垂腫瘍（腺腫もしくは癌）による虫垂重積症と診断した．開腹時，虫垂根部が盲腸内に陥入している不完全型虫垂重積症を認め，回盲部切除術およびリンパ節郭清を施行した．病理組織検査では虫垂根部を中心に絨毛腺管腺腫を認め，一部に壁深達度Mの高分化腺癌が併存していた．本邦で虫垂腺腫・癌を誘因とする虫垂重積症は検索しえたかぎり本例を含め26例であった．癌は17例で，そのうち10例（58.8%）が深達度M・SMであり，縮小手術の可能性が示唆されるが，なかには腹膜播種やリンパ節転移例もあり，その適応は慎重に行う必要があると思われる．

10.5833/jjgs.45.664

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Citations (3)

Six Cases of Inguinal Bladder Hernia Diagnosed Preoperatively

Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) (2017)

Satoru Akashi Shiho Sugimori Yoshiyuki Sasaki Yukishige Yamada

（目的）本邦では比較的稀とされている鼠径部膀胱ヘルニアについて検討を行った．

10.4030/jjcs.42.624

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Citations (1)

Annexin II overexpression is correlated with poor prognosis in human gastric carcinoma.

PubMed (2001)

Koji Emoto H Sawada Yukishige Yamada H. Fujimoto Yasushi Takahama

Annexins belong to a family of the calcium-dependent phospholipid binding proteins. They are also substrates of receptor tyrosine kinases. Overexpression of Annexin II, which has been reported in various carcinomas, is thought to be associated with cell proliferation, differentiation and cell-cell adhesion in the pathogenesis of carcinoma, but the functions of Annexins have not been fully elucidated. In this study, we investigated the role of Annexin II (p36) and its relationship with c-erbB-2 overexpression in gastric carcinoma. We studied Annexin II expression using Western blot analysis in 8 human gastric carcinoma cell lines and expression of Annexin II and c-erbB-2 using, immunohistochemistry in 153 primary gastric carcinomas. Western blot revealed that Annexin II was expressed in 8 human gastric carcinoma cell lines. It was more strongly expressed in the cell membrane than in the cytoplasm of tumor cells in primary gastric carcinoma tissues. Thirty-three percent of all cases were immunopositive for Annexin II, overexpression of which was more frequent in differentiated type (p = 0.0009), lymph node, metastasis (p = 0.0147) and venous invasion (p = 0.0092). Annexin II and c-erbB-2 overexpression were significantly correlated p = 0.0002) and patients with Annexin II had poorer prognoses (p = 0.0066). Multivariate analysis showed that immunopositivity of both Annexin II and c-erbB-2 was an independent and poor prognostic factor (p = 0.0037). In conclusion, Annexin II was overexpressed in advanced gastric carcinomas and it could contribute to the progression of gastric carcinoma.

Annexin A2

Annexin A1

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Citations (128)

Journal of the Japanese Society of Intensive Care Medicine (2008)

Makiko Uji Masahiko Kawaguchi Katsuji Hirai Tomohiro Matsuda Satoki Inoue

10.3918/jsicm.15.97

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Citations (0)