Aim of Study: The conclusions on the association between the rs2736100 polymorphisms of telomerase reverse transcriptase (TERT) gene polymorphism and digestive cancers risk are still debated. This meta-analysis was conducted to update the association between the TERT rs2736100 polymorphisms and the risk of digestive cancers. Materials and Methods: The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using the meta-analysis method. Results: Eight case-control studies were included in this meta-analysis for associating TERT rs2736100 gene polymorphism and digestive cancer susceptibility. Pooled odds ratio with 95% confidence interval was calculated using a fixed or random-effects model. Overall, no evidence has shown that the TERT rs2736100 polymorphism was associated with the susceptibility to digestive cancers. Besides, stratified analysis with ethnicity also indicated no significant association between TRET rs2736100 and the risk of digestive cancers under all genetic models in both Asian and Caucasian populations were observed. Conclusion: According to the meta-analysis, TERT rs2736100 polymorphism might be unrelated to digestive cancer susceptibility. Evidence with adequate sample size is still needed.
Objective To investigate the significance of fibroblast activation protein(FAP) expression in esophageal cancer as well as its role in early diagnosis.Methods The expression of FAP in esophageal cancer(tissue chip) was examined by immunohistochemical staining,and the result was analyzed with clinicopathological parameters.Results Fifty-seven cases of 68(83.8%) in esophageal cancer were positive expression of FAP,while normal tissues were negative.Significant correlation was found between FAP expression and the differentiation degree(P0.05).With the malignant degree of the tumor increased,the expression of FAP decreased.Its relation to the gender,age and TNM stage was not significant(P0.05).Conclusion Significant correlation was found between FAP expression and the tumor differentiation degree,and FAP may be a useful tumor marker for early diagnosis in esophageal cancer.
We report microstructure evolution and mechanical properties of Mg alloy AZ31 processed by a new severe plastic deformation technique which combines forward extrusion, equal channel angular extrusion (ECAE) and change channel angular extrusion (CCAE). Under all of the processing temperatures ranging from 623 K to 723 K, the grain size of the as-extruded sample was remarkably refined, which is attributed to the grain subdivision and dynamic recrystallization during the drastic deformation. We have also found the strength and tension-compression asymmetry were improved. Simultaneously, micro-fracture of tensile exhibited the characteristics of ductility, indicating plasticity of Mg alloy AZ31 was improved by compound channel extrusion.
Rational design of inexpensive and durable bifunctional oxygen catalysts is essential to facilitate the commercialization of Zn-air batteries. Hence, we report an electrocatalyst with bifunctional catalytic activity, namely Fe species doped into N, S co-doped carbon encapsulated Co catalysts (e-Fe/Co@NSC). Benefiting from the hierarchical porous structure and multiple adsorption sites, the optimized e-Fe/Co@NSC-20 exhibits excellent oxygen evolution reaction (OER) performance, requiring only overpotential of 282 mV to drive a current density of 10 mA cm-2. More importantly, the e-Fe/Co@NSC-20 also exhibited excellent oxygen reduction reaction (ORR) performance with a half-wave potential of 0.816 V, successfully revealing that it has excellent bifunctional properties. Moreover, Zn-air battery assembled with e-Fe/Co@NSC-20 catalyst as air electrodes have high open-circuit voltage (1.472 V), power density (136 mW cm-2) and specific capacity (639 mAh g-1Zn), outperforming Pt/C+RuO2-based Zn-air battery. This study provides constructive assistance in the design of electrocatalysts with bifunctional properties for Zn-air battery.
Objective: To investigate the expression of β1-integrin and Shh in colorectal cancer and their relationship.Methods: Immunohistochemical method of SP was used to exam β1-integrin and Shh expression in the cases of colorectal cancer,moreover,the correlation between them were analyzed.Results: In colorectal cancer,positive expression rate of β1-integrin was 59.42%,and the positive expression rate of Shh was 71.01%.Significant differences in the expression of β1-integrin was found in different depth of invasion,lymph node metastasis and TNM staging(all P0.05).No significant differences in the expression of β1-integrin was found in different gender,age and pathological grading,while significant difference in the expression of Shh was only found in different pathological grading(P0.05).A positive correlation was found between the expression of β1-integrin and Shh(P0.05).Conclusion: The positive expression of β1-integrin was related to the depth of invasion,lymph node metastasis and TNM staging,and the expression of Shh and β1-integrin in colorectal cancer was correlated.The combined detection of β1-integrin and Shh may be of important clinical value for evaluating the degree of malignancy of colorectal cancer as well as better understanding the biological basis of cancer and finding effective treatments.
Many problems of GCr15SiMn high-carbon chromium bearing steel have been found in the ordinary grinding (OG) process. Aiming at the problems of high grinding force, low residual compressive stress and low surface quality, ultrasonic machining technology is combined with OG. The test of ultrasonic vibration assisted grinding (UVAG) GCr15SiMn high carbon chromium bearing steel is carried out. The residual stress, surface roughness, grinding force, and surface morphology are analyzed by changing machining parameters. The research showed that as the grinding depth and feed speed become larger, the grinding force increased, when the spindle speed rises, the grinding force becomes smaller. In the test range, with the ultrasonic amplitude from small to large, the grinding force from large to small. The ultrasonic grinding force is 27.8% lower than that of OG. The surface roughness increases with increasing grinding depth and feed speed and decreases with increasing spindle speed and ultrasonic amplitude, and at an amplitude of 6 μm, the surface roughness is reduced by 27% compared to OG. When the feed speed and grinding depth are lowered or the ultrasonic amplitude is increased, the surface residual compressive stress is increased. Compared to OG, it is increased by more than 13.5% under the same parameters. At the same time, the phenomenon of burrs and surface tears can be reduced, and the surface quality of the workpiece becomes better.
A key challenge for the effective treatment of intestinal diseases, including inflammatory bowel disease (IBD), is to develop an oral drug delivery system that can resist gastric acid erosion and efficiently release drugs after rapid entry into the intestine. In the present work, we developed oral composite nanoparticles (MSZ@PRHS) consisting of a rough mesoporous silica (RHS) loaded with Mesalazine (MSZ) and a CAP polymer membrane for targeted relief of inflammation in colitis. At the pH values of the simulated stomach and small intestine, the release rate of MSZ from MSZ@PRHS was low, while at the pH values of the simulated colon, the release rate of MSZ was high. In dextran sulfate sodium salt (DSS)-induced acute colitis mouse model, compared with oral administration of the drug Mesalazine in the equivalent solution form, oral administration of PRHS loaded with drug-loaded nanoparticles can significantly alleviate the symptoms of inflammatory bowel disease, and improve the therapeutic effect. We propose that the intestinal microenvironment provides an interface for nanocomposites switch and a promising drug delivery platform for the management and treatment of many intestinal diseases, where controlled drug release and prolonged residence time are required.
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