Wu Ym

Salford Royal Hospital

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Liu Zy

Jiangxi University of Traditional Chinese Medicine

Xu Lx

First Affiliated Hospital of Chinese PLA General Hospital

Cao Yb

First Affiliated Hospital of Chinese PLA General Hospital

Da Wm

Chinese PLA General Hospital

Tsai Cc

Tainan Municipal Hospital

Wu Xx

First Affiliated Hospital of Chinese PLA General Hospital

Bo Yan

Zhejiang Chinese Medical University

Wang Jc

University of Southern California

He Rr

Hebei Medical University

Li Xh

Liaocheng People's Hospital

Cooperative Institutions

First Affiliated Hospital of Chinese PLA General Hospital

University of Pittsburgh

Chinese Academy of Sciences

Kaohsiung Medical University

University of Iowa

Chinese PLA General Hospital

Taipei Veterans General Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Xuzhou Medical College

University of Pittsburgh Medical Center

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[Clinical observation of haploidentical-hematopoietic stem cell transplantation combined with human umbilical cord-derived mesenchymal stem cells for severe aplastic anemia-II].

PubMed (2014)

Xu Lx Liu Zy Wu Ym Cao Yb Li Xh

This study was purposed to investigate the efficacy and safety of haploidentical hematopoietic stem cells (allo-HSCT) transplantation combined with human umbilical cord-derived mesenchymal stem cell infusion (hUC-MSC) for severe aplastic anemia-II (SAA-II). Eight SAA-II patients received haploidentical allo-HSCT, the G-CSF mobilized peripheral hematopoietic stem cells and bone marrow haploidentical hematopoietic stem cells were selected as graft, the human umbilical cord-derived mesenchymal stem cells (hUC-MSC) were infused as the third party. Conditioning regimen consisted of rabbit anti-thymic lymphocytes protein(ATG), cyclophosphamide(CTX) and fludarabine(Flu). For two patients out of 8 SAA-II patients the conditioning regimen was combined with busulfan(BU). The graft versus host disease(GVHD) was prevented with CSA, MTX, ATG, CD25 and mycophenolate mofetil. The results showed that the average number of nucleated cells were 9.13×10(8)/kg, and number of CD34(+)cells were 3.76×10(6)/ kg. All the 8 SAA-II patients achieved hematopoietic reconstitution. The average time of neutrophils count>0.5×10(9)/L was 11.9 days, and average time of Plt level >20×10(9)/L was 14.6 days. The incidence of acute GVHD of I-II grade was 25%, and that of III-IVgrade was 12.5%, the transplantation-related mortality was 25%. It is concluded that haploidentical allo-HSCT combined with umbilical cord MSC infusion is an effective approach to cure SAA.

Aplastic anemia

Cord blood

10.7534/j.issn.1009-2137.2014.03.037

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[TGF-beta 1 in the experimentally induced inflammatory periodontal tissues in miniature swines].

PubMed (1999)

Ko Wl Wang Jc Chen Cc Wu Ym Tsai Cc

TGF-beta 1 is a multifunctional molecule which has unique and potent effects on many target cells and tissues. TGF-beta 1 may promote inflammatory reaction by certain intercellular interaction. TGF-beta 1 at extremely low concentrations shows strong chemotatic activity for mononuclear phagocytes and stimulates bone resorption by enhancing production of PGE2. On the other hand, TGF-beta 1 plays a very important role in the regulation of extracellular matrix turnover presumably by modulating the action of other growth factors on matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) expression. TGF-beta 1 was identified intra- and extracellularly in the inflamed gingival tissues and the distribution was associated with areas of inflammation. Sixteen miniature swines were used in this experimental gingivitis/periodontitis study. The ligatures were placed in situ for periods of 3, 5, 8 and 13 weeks and peroral innoculations of Porphyromonas gingivalis/Actinomyces viscosus into the ligatures were carried out only in the experimental group. ELISA was used to measure the levels of TGF-beta 1 in gingival tissues from the experimental and control groups. Recording of the clinical periodontal parameters was performed and the proportion of black-pigmented Bacteroides in the ligature (plaques) removed immediately prior to the biopsies was recorded. The results revealed that the concentration of TGF-beta 1 of the experimental group was higher and significantly different in statistics on the period of third week than that of the control group. The concentration of TGF-beta 1 was significantly different between the third week and the thirteenth week in the experimental group, and was negatively related to the time-length of ligatures. Furthermore, the concentration of TGF-beta 1 was negatively related to the changes of the calculus index and gingival index. These data indicated that the concentration of TGF-beta 1 of gingival tissue exhibited dynamic changes associated with the progression of experimental periodontal inflammation. The levels of TGF-beta 1 in gingival tissue may be valuable in detecting the inflammatory reaction of periodontal tissues.

TGF beta 1

BETA (programming language)

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Citations (4)

A proposal for an appropriate nomenclature to late-onset cognitive impairment for Hong Kong in the 21st century: dementia revisited.

PubMed (2012)

Lam L Lau Kk Vincent Mok Huang Cy SW Li

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[Effect of intrahippocampal microinjection of enkephalin on cellular immune function and brain IL-1 alpha gene expression in rat].

PubMed (1996)

Wang Aj Yang Yz Wu Ym Hua Xie Hu Mx

The effect of intrahippocampal microinjection of enkephalin on cellular immune function and hippocampal IL-1 alpha gene expression was studied in rats. The results showed that: (1) The proliferation activity of splenic lymphocytes stimulated by Con A was significantly increased with microinjection of Leu-enkephalin 1 microliter (18 mmol/L) or Met-enkephalin 1 microliter (18 mmol/L) into bilateral hippocampus, but was inhibited by Lipopolysaccharide 1 microliter (50 ng/microliter). The proliferative response of splenic lymphocytes to Leu-enkephalin still persisted after bilateral adrenalectomy. Low doses of Leu- or Met-enkephalin (10(-10), 10(-11) mol/L) were also capable of causing proliferative activity of the Con A- stimulated cultured splenic lymphocytes in vitro. (2) Using RT-PCR technique, IL-1 alpha gene expression was detected in hippocampus 90 min after bilateral intrahippocampal injection of LPS. The LPS-induced IL-1 alpha gene expression in hippocampus could no longer be detected 30 min after microinjection of Met- or Leu-enkephalin into hippocampus. The above results suggested that intrahippocampal enkephalin might play an important role in neuro-immunomodulation by enhancing the inhibition of IL-1 alpha gene expression in hippocampal formation.

Met-enkephalin

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Effects of mifepristone compound on the receptors of estrogen and progesterone in early pregnancy deciduas.

Reproduction and contraception (2000)

Liu Jin Shen Wx Sun Zd Fan Gs Wu Ym

The aim was to examine the effect of mifepristone compound (mifepristone plus anordrin) on estrogen receptors (ER) and progesterone receptors (PR) in early pregnancy decidua. A controlled study was carried out among 60 normal early pregnant volunteers (49 or fewer days) in the Department of Obstetrics and Gynecology at Peking Union Medical Hospital. The concentrations of ER and PR were measured by radioligand and were compared with the control subjects after oral administration of mifepristone or mifepristone compound in different doses. The concentration of PR decreased while that of ER increased significantly in the decidua of all subjects administered mifepristone compound. The authors also found the concentration of EcR in Group 5 (mifepristone 30 mg + AF-53 5 mg) to be the highest among 6 groups. The compound may favor estrogens action on the endometrium. The results indicate that mifepristone compound with AF-53 has a coordinated function and can change the proportion of PR and ER. Hence it can facilitate abortion. The compound dose of mifepristone 30 mg + AF-53 5 mg favors the endometrium recovering. (authors modified)

Decidua

Abortifacient

Medical abortion

Progesterone receptor

Hormone antagonist

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Refinement of edge-to-edge matching model and its application in the Mg17Al12/alpha-Mg and alpha-Y/alpha-Mg systems

Jimin Yang Wang Jl Wang Ld Wu Ym Limin Wang

A refined version of the edge-to-edge matching model is described here. In the original model, the matching directions were obtained from the planes with all the atomic centers that were exactly in the plane, or the distance from the atomic center to the plane which was less than the atomic radius. The direction-matching pairs were the match of straight rows-straight rows and zigzag rows-zigzag rows. In the refined model, the matching directions were obtained from the planes with all the atomic centers that were exactly in the plane.

Zigzag

Alpha (finance)

Center (category theory)

Atomic radius

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[Advances in family planning].

PubMed (1993)

Wu Ym

China made many achievements in research and development in family planning during 1992. The State Family Planning Commission issued 15 awards for technological progress including three second prizes and 12 third prizes. The Ministry of Public Health approved a series of newly developed contraceptive drugs and devices for clinical trials and trial production in order to observe their safety any undesirable reactions and acceptability. (excerpt)

Christian ministry

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Intrahepatic arterial chemoembolization for hepatocellular carcinoma and metastatic neuroendocrine tumors in the era of liver transplantation.

PubMed (1996)

Molly E. Martin Deborah Tarara Wu Ym Ferdinand O. Ukah Alfredo J. Fabrega

Surgical resection has been the standard approach for primary and metastatic liver tumors. Long-term survival, however, is limited because of recurrence or hepatic decompensation. Failure of chemotherapeutic regimens or liver transplantation (OLT) to prevent recurrence has resulted in the need for multimodality therapies. We report our experience with preoperative hepatic arterial chemoembolization (CET) followed by OLT in highly select patients. Over a 33-month period, 23 of 41 patients (56%) referred with primary (n = 16) or metastatic neuroendocrine (n = 7) liver tumors met eligibility requirements. Despite mild, self-limited chemical hepatitis, CET was well tolerated in all but three elderly patients who succumbed to liver failure. Four of five patients ultimately received OLT. Three are alive and free of disease at a mean followup of 17 months, one died of recurrent hepatocellular carcinoma, and one (NET) remains well at 33 months with elevated glucagon levels but no measurable disease. All NET patients are alive with resolution of hormonal symptoms. Four of five noncirrhotic patients died of disease, and one has progressive tumor growth. Although OLT following CET achieves superior survival, its application is limited to a minority of patients with such tumors. Careful pretreatment staging and patient selection combined with caution in the use of CET in elderly cirrhotic patients is critical to the success of such therapies.

Decompensation

Liver disease

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Citations (28)

Biphasic activation of renal afferent by intrarenal artery injection of bradykinin in anesthetized rabbits.

PubMed (1999)

Wu Ym He Rr

The effect of intrarenal artery injection of bradykinin (BK, 5.0 micrograms/kg) on multi- and single-unit recordings of afferent renal nerve activity (ARNA) was examined in anesthetized 48 rabbits. The results obtained are as follows. (1) There were two phases of increase in ARNA following intrarenal BK. The early phase occurred immediately while the delayed phase made its appearance about 7 min later. The degree of increase in ARNA of the delayed phase induced by intrarenal BK was more prominent than that in the early phase. BP was actually unaltered following intrarenal BK. (2) By pretreatment with indomethacin (Indo, 5.0 mg/kg), the delayed phase of increase in ARNA induced by intrarenal BK was attenuated, while the early phase was not affected. (3) Pretreatment with L-NAME (30 mg/kg) led the delayed phase to be blocked completely while the early phase was partially decreased. From the above-mentioned observations, it is concluded that intrarenal BK induces a significant increase in ARNA in two phases. The early phase may be due to the direct action of BK and partially due to the NO action, while the delayed phase may be attributed to the action of released prostaglandin and NO as a result of intrarenal BK.

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Citations (4)

[Serum immunoglobulins and complement components in patients with periodontal disease].

PubMed (1985)

Huang Js Chen Cc KY Ho Wu Ym Hou Gl

Complement

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