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BD Young

St Bartholomew's Hospital

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Papers

Citation

H-Index

i-10 index

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Document Type

Co-Authors

Susheela Dhut

The Honourable Society of Lincoln's Inn

Tracy Chaplin

Queen Mary University of London

TA Lister

St Bartholomew's Hospital

Lister Ta

Blood Cancer UK

TS Ganesan

Cancer Institute (WIA)

Ravindra K. Gupta

Africa Health Research Institute

Finbarr E. Cotter

Queen Mary University of London

H White

DM Lillington

Royal London Hospital

J. G. Bodmer

University College London

Cooperative Institutions

St Bartholomew's Hospital

University College London

Cancer Research UK

Blood Cancer UK

Hammersmith Hospital

Royal Victoria Hospital

University of Ulster

Institute of Cancer Research

Medical Research Council

London Postgraduate Medical and Dental Education

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Papers

Citation

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Molecular cloning of a novel 11q23 breakpoint associated with non-Hodgkin's lymphoma.

Meerabux Jm Cotter Fe Robert E. Kearney Dean Nižetić Susheela Dhut

Cosmid

Breakpoint

Gene rearrangement

Chromosome regions

Chromosomal rearrangement

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Citations (12)

The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene

Tracy Chaplin Olivier Bernard HB Beverloo Vaskar Saha A Hagemeijer

Motif (music)

10.1182/blood.v86.6.2073.bloodjournal8662073

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Citations (139)

Expression of the ABL-BCR fusion gene in Philadelphia-positive acute lymphoblastic leukemia

JV Melo DE Gordon Anna Tuszynski Susheela Dhut BD Young

breakpoint cluster region

Philadelphia chromosome

ABL

10.1182/blood.v81.10.2488.bloodjournal81102488

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Citations (3)

Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia

Leukemia (2001)

L.A. Jones Tracy Chaplin Ananth Shankar Michael Neat Naina Patel

Fusion transcript

Acute megakaryoblastic leukemia

10.1038/sj.leu.2402140

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Citations (21)

Normal c-abl gene protein--a nuclear component.

Susheela Dhut Tracy Chaplin BD Young

Cell fractionation

K562 cells

ABL

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Citations (20)

Molecular abnormalities in leukemia: the 11q23 story so far.

A Gregorini Caterina Cinti BD Young

Various hematopoietic malignant disorders have been shown to bear chromosome abnormalities of the 11q23 band, which can be rearranged with many different chromosomal regions in a wide variety of different leukemia subtypes. Several laboratories have identified a trithorax-related gene that is involved in most of the 11q23 abnormalities. Although some patterns and associations between the partner genes are beginning to emerge, it is not yet possible to frame a single unifying hypothesis for 11q23 leukaemic transformation. The aim of this review is to summarise the recent data concerning these 11q23 rearrangements and the understanding of their consequences.

Malignant Transformation

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Citations (4)

BCR-ABL and BCR proteins: biochemical characterization and localization.

Susheela Dhut Tracy Chaplin BD Young

breakpoint cluster region

Cell fractionation

ABL

Philadelphia chromosome

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Citations (53)

Human trithorax gene rearrangements in therapy-related acute leukaemia after etoposide treatment.

Mark Bower Pauline Parry Barbara Gibbons J. Amess Lister Ta

Gene rearrangement

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Citations (21)

Simultaneous presentation of T- and B-cell malignant lymphoma with bcl- 2 gene involvement

FE Cotter PA Hall BD Young TA Lister

10.1182/blood.v73.5.1387.1387

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Citations (15)

Rearrangement of the bcr gene in Philadelphia chromosome-negative chronic myeloid leukemia

TS Ganesan Feyruz V. Rassool AP Guo KH Th'ng C. Dowding

breakpoint cluster region

Philadelphia chromosome

Gene rearrangement

10.1182/blood.v68.4.957.957

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Citations (85)