200 Objectives The aim of this study was to define whether the combinaition of 68Ga-DOTATATE and 18F-FDG could be helpful for the differential diagnosis in the sellar lesions. Methods We evaluated 86 consecutive subjects suspicion of sellar lesions, including primary pituitary adenoma(n=34,PPA), recurrent pituitary adenoma(n=35,RPA),Rathke’s cleft cyst(n=5,RCC),pituitary infection (n=3,PI) , pituitary lymphocytic hypophysitis (n=2,PLH), langerhans cell histiocytosis(n=3,LCH), meningiomas (n=2),craniopharyngioma(n=2), who underwent both FDG PET/CT and DOTATATE within one week. The final diagnosis was based on the pathology and follow-up. Results DOTATATE detected higher-uptake tissue which showed minimal FDG uptake confirmed residual pituitary gland in 33 patients with RPA,,whereas cannot detect pituitary gland in two cases. FDG detected hypermetabolic tissue in 34 patients with RPA confirmed tumors ,whereas cannot detect tumor in one case.DOTATATATE uptake in residual tumor is variable: 25 show moderate uptake ,9 show minimal uptake and 1 show void uptake,whereas the degree of uptake in moderate group is lower than residual pituitary gland(P=0.005). 34 PPA showed intense two tracer uptake.2 meningiomas showed intense uptake of DOTATATE and minimal uptake of FDG.These two tracer uptake in cyst content was absent with RCC. 3 PI and 2 PLH showed extension to the sellar and minimal uptake of two tracer. 3 LCH showed moderate two tracers uptake in the involved region.2 craniopharyngioma showed moderate two tracers uptake in the solid component. Conclusions The combination with FDG and DOTATAE can be valuable in the differentiation pituitary adenoma and meningiomas , pituitary adenoma and pituitary inflammatory, while have to referenced to morphological imaging in some lesions.Furthermore, this technique allows differentiation recurrent pituitary adenoma and normal pituitary gland from postoperative formation.
Y-box-binding protein-1 (YB-1) is aberrantly expressed in a variety of cancers. However, the biological functional role of YB-1 in glioma is not yet clear.The expression of MDM2 and YB-1 was analyzed by real time PCR. Overexpression and knockdown of YB-1 in glioma cells were created by transfection of pcDNA-YB-1 and siRNA against YB-1, respectively. Cell viability was performed by CCK8 assay.Our findings showed that glioma tissues had higher expressions of YB-1 than that in cancer-free tissues in 54 glioma patients, which were also positively correlated with Murine MDM2 expression. Overexpression of YB-1 or MDM2 renders a drug resistance feature in glioma cell exposed to temozolomide (TMZ), by directly targeting p53. Genetic or chemical inhibition of MDM2 significantly blocked YB-1-modulated response of glioma cells to TMZ. Moreover, inhibition of YB-1 or MDM2 reduced glioma cells metastasis and mortality in mice.YB-1 facilitates the resistance of glioma cells to TMZ by direct activation of MDM2/p53 signaling and represents a promising molecular target for glioma treatment.
This study aims to systematically assess the effectiveness and safety of acupuncture on hearing loss (HL) after traumatic brain injury (TBI).In this study, the following databases will be retrieved from inception up to the May 1, 2019: PUBMED, EMBASE, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. All databases will be retrieved without any language restrictions. Two reviewers will independently carry out article selection, data collection, and risk of bias evaluation. Any disagreements will be solved by a third reviewer through discussion.This study will systematically investigate the effectiveness and safety of acupuncture for treating HL after TBI through evaluating HL assessment, hearing threshold, quality of life, and adverse events.The expected findings of this study will provide latest evidence for assessing the effectiveness and safety of acupuncture for HL after TBI.This study is supposed to be published in a peer-reviewed journal. No ethical approval is needed because this study will based on the literature analysis, but not the individual patient.PROSPERO CRD42019133417.
The evaluation of the remaining pituitary tissue and recurrent or residual tumor after the pituitary adenoma resection is difficult. However, it is essential to assess the size of the recurrent tumor and remaining pituitary reserve before resurgery. This study aimed to distinguish the remaining pituitary tissue from pituitary adenoma with Ga 1,4,7,10-tetraazacyclododecane-N,N',N″,N″'-tetraacetic acid-D-Phe,Tyr3-octreotate (DOTATATE) and F-FDG PET imaging in patients status post transsphenoidal adenomectomy.Thirty-five patients with suspected recurrent/residual pituitary tumors were retrospectively evaluated. All of these patients underwent DOTATATE and FDG PET/CT within 1 week before additional surgery. The DOTATATE and FDG uptake levels were compared. The image findings were then compared with pathology results after the additional surgery.Residual or recurrent pituitary adenoma were confirmed pathologically in all 35 patients. One recurrent pituitary adenoma did not have either DOTATATE or FDG uptake. In the remaining 34 adenomas, 33 had higher FDG uptake than DOTATATE uptake. In comparison, DOTATATE had significant higher uptake than FDG in the remaining pituitary tissues in all cases.Different degree of uptake of Ga DOTATATE and F-FDG PET/CT in the remaining pituitary tissue and recurrent/residual pituitary tumor indicated that combined analysis of Ga DOTATATE and F-FDG PET/CT might be of clinical value in differentiating recurrent/residual pituitary adenoma from the remaining pituitary tissue.
In order to reduce the cost and establish the wireless network for smart home system, and realize the integration of router and smart home control gateway, this paper proposes a low-cost design of routing gateway for smart home. With Openwrt open source routing system and Luci WEB framework, using WiFi and Zigbee as the main communication network, we design the frame structure of communication data and developed control interface for smart home, to meet the users' needs of surfing the Internet and the control of the equipment and check the room information of the family. The experimental results show that users can control home wireless devices and view room information through webpage, and realize the integration of various wireless communication modes and the establishment of wireless network for smart home system. The design of this paper has a certain practical significance for the existing smart home industry.
561 Objectives This study was designed to determine the value of 68Ga-DOTATATE PET/CT in identifying the pituitary adenoma and correlate the 68Ga-DOTATATE accumulation with the corresponding hormone levels in the patients, which was compared with 18F-FDG PET/CT in the same patients. Methods 68GA-DOTATATE and 18F-FDG PET/CT were performed in 47 patients (Female 30, Male 17, aged 15-68 years) with suspicious adenoma on MRI and were diagnosed as pituitary adenoma pathologically or clinically. The mean SUV and the volume of the tumors were measured and the active tumor volume (ATV) was calculated by volume×SUVmean. The hormone levels at the same period were collected for correlation. Results In the 47 patients, 20 were proved with growth hormone (GH) adenoma, 10 had adrenocorticotropic hormone (ACTH) tumor, 7 had prolactin (PRL) adenoma, and 10 had non-functional adenomas. All adenomas were found with both 68GA-DOTATATE accumulation and 18F-FDG uptake except for one patient who was also negative MRI but confirmed with a very small ACTH adenoma by surgery and pathology finally. Significant correlations were found between the ATV in 68GA-DOTATATE PET/CT with the serum insulin-like grown factor-1 levels in the patients with GH tumor (n=20, P=0.033) and the serum PRL levels in the patients with PRL tumor (n=7, P=0.007), but not with the 24-h urinary cortisol levels in patients with ACTH tumor (n=9, P=0.600). There was no significant difference of 68GA-DOTATATE accumulation between the different kinds secretary adenomas and the non-functional adenomas (P>0.05). There was significant correlation between the 68GA-DOTATATE accumulation and the 18F-FDG uptake in the adenomas (P Conclusions The 68GA-DOTATATE-avid tumor volume seemed to have a correlation with the hormone levels in patients with pituitary PRL or GH adenoma.
Objective To investigate the mechanism of intracranial paeudoaneurysm forming, to enhance cure rate and decrease mortality and morbidity. Method Data from 17 patients underwent surgical treatment after 2004 were collected. Clinical characteristics and surgical results of patients with intracranial paeudoaneurysm were assessed. Results 17 cases were dignosised by CT,3D-CTA, DSA and others clinical manifestations. All of the patients were treated by clipping/sticking the neck of aneurysm. 1 cases died, 1 cases was severe disability,4 cases were mild disability. Conclusions Intracranial pseudoaneurysm is a special category in intracranial aneurysm. Bleeding rate was higher than other types in preoperation and interoperation. Early diagnosis is important in preventing secondly hemorrhage, early operation is necessary in decrease morbidity and mortality.
Key words:
Intracranial aneurysm; Pseudoaneurysm; Surgical procedures,operative
Abstract: Poststroke depression (PSD), the most common psychiatric disease that stroke survivors face, is estimated to affect ~30% of poststroke patients. However, there are still no objective methods to diagnose PSD. In this study, to explore the differential metabolites in the urine of PSD subjects and to identify a potential biomarker panel for PSD diagnosis, the nuclear magnetic resonance-based metabonomic method was applied. Ten differential metabolites responsible for discriminating PSD subjects from healthy control (HC) and stroke subjects were found, and five of these metabolites were identified as potential biomarkers (lactate, α-hydroxybutyrate, phenylalanine, formate, and arabinitol). The panel consisting of these five metabolites provided excellent performance in discriminating PSD subjects from HC and stroke subjects, achieving an area under the receiver operating characteristic curve of 0.946 in the training set (43 HC, 45 stroke, and 62 PSD subjects). Moreover, this panel could classify the blinded samples from the test set (31 HC, 33 stroke, and 32 PSD subjects) with an area under the curve of 0.946. These results laid a foundation for the future development of urine-based objective methods for PSD diagnosis and investigation of PSD pathogenesis. Keywords: poststroke depression, PSD, stroke, nuclear magnetic resonance, NMR, metabonomic
Abstract Background: This systematic review aims to investigate the effectiveness and safety of neuromuscular electrical stimulation (NMES) on hearing loss (HL) caused by skull base fracture (SBF). Methods: We will retrieve the following electronic databases of Cochrane Library, PUBMED, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database from the inception to January 1, 2019 for relevant RCTs of NMES for HL caused by SBF. Two experienced authors will independently perform the study selection, data extraction, and methodology quality assessment. A 3rd author will solve any disagreements between 2 authors through discussion. Results: This study will provide a high-quality synthesis of latest evidence of NMES for HL caused by SBF from comprehensive assessments, including hearing loss evaluation, hearing threshold, quality of life, and any relevant adverse events. Conclusion: The expected results of this systematic review will provide the up-to-date evidence to assess the effectiveness and safety of NEMS for patients with HL caused by SBF. Ethics and dissemination: The results of this study will be disseminated through publication in a peer-reviewed journal or will be presented at an associated conference meeting. This study will not use individual patient data, thus, the ethical approval is not needed. PROSPERO registration number: PROSPERO CRD42019120195.
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