Huafei Luo

Shanghai Institute of Pharmaceutical Industry

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Hao Wang

Chinese Academy of Sciences

Zhuangzhi Zhu

Tongling Nonferrous Metals Group Holding (China)

Yubo Wu

South Texas Veterans Health Care System

Jing Luo

Shanghai Institute of Pharmaceutical Industry

Wangding Lu

University of Copenhagen

Junyu Zhang

Lishui Central Hospital

Hansen Luan

Shanghai Institute of Pharmaceutical Industry

Guobei Lin

Shanghai Institute of Pharmaceutical Industry

Chenghao Zhang

Harbin Institute of Technology

Zhiqiang Ku

Brown Foundation

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Shanghai Institute of Pharmaceutical Industry

University of Chinese Academy of Sciences

Chinese Academy of Sciences

Shanghai Jiao Tong University

Institut Pasteur of Shanghai

Shanghai Institutes for Biological Sciences

Beijing Institute of Technology

Shanghai Medical College of Fudan University

Brown Foundation

The University of Texas Health Science Center at Houston

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Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study

Journal of Chromatography B (2015)

Chenghao Zhang Huafei Luo Yubo Wu Junyu Zhang Furong Zhang

Trifluoroacetic acid

10.1016/j.jchromb.2015.12.043

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Citations (5)

Preparation and the Biopharmaceutical Evaluation for the Metered Dose Transdermal Spray of Dexketoprofen

Journal of Drug Delivery (2014)

Wangding Lu Huafei Luo Zhuangzhi Zhu Yubo Wu Jing Luo

The objective of the present work was to develop a metered dose transdermal spray (MDTS) formulation for transdermal delivery of dexketoprofen (DE). DE release from a series of formulations was assessed in vitro. Various qualitative and quantitative parameters like spray pattern, pump seal efficiency test, average weight per metered dose, and dose uniformity were evaluated. The optimized formulation with good skin permeation and an appropriate drug concentration and permeation enhancer (PE) content was developed incorporating 7% (w/w, %) DE, 7% (v/v, %) isopropyl myristate (IPM), and 93% (v/v, %) ethanol. In vivo pharmacokinetic study indicated that the optimized formulation showed a more sustainable plasma-concentration profile compared with the Fenli group. The antiinflammatory effect of DE MDTS was evaluated by experiments involving egg-albumin-induced paw edema in rats and xylene-induced ear swelling in mice. Acetic acid-induced abdominal constriction was used to evaluate the anti-nociceptive actions of DE MDTS. Pharmacodynamic studies indicated that the DE MDTS has good anti-inflammatory and anti-nociceptive activities. Besides, skin irritation studies were performed using rat as an animal model. The results obtained show that the MDTS can be a promising and innovative therapeutic system used in transdermal drug delivery for DE.

Biopharmaceutical

10.1155/2014/697434

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Citations (15)

Preparation and characterization of a metered dose transdermal spray for testosterone

Acta Pharmaceutica Sinica B (2013)

Wangding Lu Huafei Luo Yubo Wu Zhuangzhi Zhu Hao Wang

The objective of the present work was to develop a metered dose transdermal spray (MDTS) formulation for transdermal delivery of testosterone and to characterize its efficacy. Testosterone release from a series of formulations was assessed in vitro. Skin from hairless mice was used in permeation experiments with Franz diffusion cells. The spray pattern, pump seal efficiency, average weight per metered dose and dose uniformity were evaluated. An optimized formulation containing 10% (w/v) testosterone, 9% (v/v) azone and 91% (v/v) ethanol was based on good skin permeation and acceptable drug concentration and permeation enhancer (PE) content. A skin irritation study indicated that the formulation was non-irritating in a rat model. An in vivo pharmacokinetic study indicated that the optimized formulation showed a different plasma concentration-time profile from that of the commercially available product Testopatch®. The Testopatch® product demonstrated a more sustainable drug release. The evaluation of the testosterone MDTS indicated that it could deliver reproducible amounts of the formulation per actuation. The results obtained showed that the MDTS is a potential alternative therapeutic system for transdermal testosterone delivery.

10.1016/j.apsb.2013.10.003

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Citations (18)

Rapidly Dissolvable Microneedle Patches for Transdermal Delivery of Exenatide

Pharmaceutical Research (2014)

Zhuangzhi Zhu Huafei Luo Wangding Lu Hansen Luan Yubo Wu

Transepidermal water loss

10.1007/s11095-014-1424-1

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Citations (114)

Transcutaneous immunization via rapidly dissolvable microneedles protects against hand-foot-and-mouth disease caused by enterovirus 71

Journal of Controlled Release (2016)